Product name :Apaf1

Catalog Number :000054A

Quantity :250ul

Price :621 Eur

Pay now with :

Supplier :ABM Goods

Alias KIAA0413
Protein Type Apoptosis Regulator
Protein Family CED4
Functions Oligomeric APAF1 mediates the cytochrome c-dependent autocatalytic activation of procaspase 9 (APAF3), leading to the activation of Caspase3 and apoptosis. This activation requires ATP.
Cell Types Ubiquitous; highly expressed in spleen, blood, hematopoietic tissues and peripheral blood leukocytes.
Protein Location Cytoplasm
Chromosome 12q23
Protein Structure Its a 141839 Da, 1237 amino acid residue protein. It’s a monomer and contains 1 CARD domain, 13 WD repeats (Trp-Asp domains)and 1 NB-ARC domain. It oligomerizes upon binding of Cytochrome-C and dATP. Oligomeric APAF1 and procaspase9 bind to each other via their respective NH2-terminal CARD domains and consecutively mature caspase9 is released from the complex. 5 isoforms; 1/APAF1XL, 2/ APAF1L, 3/ APAF1S, 4/ APAF1M and 5/ APAF1XS; are produced by alternative splicing.
Tags No Tags
Gene Type Wild Type
Titer 1x106pfu/mL
Storage DMEM with 2.5% glycerol
Caution This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information.
Notes The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. All sales are final.

 

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