Product name :ERK5 (dn)

Catalog Number :000088A

Quantity :250ul

Price :621 Eur

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Supplier :ABM Goods

Alias BMK1, MAPK7, PRKM7
Protein Type Kinase
Protein Family MAPK Family
Functions It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G-Protein-Coupled Receptors. In the nucleus, it regulates gene expression by phosphorylating, and activating different transcription factors, it plays an important role in differentiation of muscle cells.
Cell Types Widely expressed, abundant in heart, placenta, lung, kidney and skeletal muscle, not detectable in liver.
Protein Location Cytoplasm and nucleus
Chromosome 17p11.2
Protein Structure ERK5 contains 815 amino acids and has an approximate molecular weight of 88.6 kDa. It has a conserved thr-glu-tyr activation motif and uncharacteristic 400-amino acid C-terminal regulatory domain. The provided recombinant adenovirus contains dominant negative form of human ERK5 (AF) sequence. The ERK5 (AF) mutant cannot be phosphorylated, since the dual phosphorylation site T218/Y220 has been changed to A218/F220.
Tags No Tags
Gene Type Dominant Negative
Titer 1x106pfu/mL
Storage DMEM with 2.5% glycerol
Caution This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information.
Notes The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. All sales are final.

 

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