Product name :HIF1a

Catalog Number :000019A

Quantity :250ul

Price :621 Eur

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Supplier :ABM Goods

Alias BHLHE78, MOP1, PASD8
Protein Type Transcription Regulator
Protein Family Basic Helix-Loop-Helix (bHLH) Family of Transcription Factors
Functions It is involved in the induction of oxygen regulated genes. It specifically recognizes an 8 bp hypoxia response element (HRE). From the CMV promoter, the HIF1a gene will be constitutively expressed. It is important to note that because the recombinant gene is a wild-type, the expressed protein will functioned in natural conditions. The protein will function only in hypoxic conditions.
Cell Types It is expressed in most tissues. Highest levels are found in kidney and heart.
Protein Location Nuclear
Chromosome 14q21-q24
Protein Structure HIF1Alpha contains 826 amino acids and has an approximate molecular weight of 92670 Da. It contains a bHLH -PAS domain at its N-terminus. The basic helix-loop-helix protein juxtaposed to a stretch of approximately 300AA, termed the PAS (PER - ARNT - SIM) domain containing two internal repeats, required for heterodimerization and DNA binding and C terminal hypoxia-inducible transactivation domains, a transcriptional inhibitory domain.
Tags No Tags
Gene Type Wild Type
Titer 1x106pfu/mL
Storage DMEM with 2.5% glycerol
Caution This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information.
Notes The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. All sales are final.

 

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