Product name :MEK5(dn)

Catalog Number :000100A

Quantity :250ul

Price :621 Eur

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Supplier :ABM Goods

Alias MAP2K5, MKK5, PRKMK5
Protein Type Kinase
Protein Family MAPKK (Mitogen-Activated Protein Kinase Kinase) Family
Functions MEK5 interacts specifically with ERK5, and not with another MAP kinase like p38 may interact with GTPases such as CDC42 and acts as a critical target of the aPKCs during mitogenic signaling.
Cell Types Widely expressed, abundant in heart and skeletal muscle.
Protein Location Cytoplasm
Chromosome 15q22.2-q22.31
Protein Structure MEK5 contains 438 amino acids and has an approximate molecular weight of 49 kDa. It has 11 conserved kinase subdomains and differs from other MEKs in having a long N-terminal sequence. The provided recombinant adenovirus contains dominant negative form of human MEK5 sequence with three copies of HA epitope at C-terminal. The MEK5 (A) mutant cannot be phosphorylated, since the dual phosphorylation site S311/S315 has been changed to A311/A315.
Tags No Tags
Gene Type Dominant Negative
Titer 1x106pfu/mL
Storage DMEM with 2.5% glycerol
Caution This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information.
Notes The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. All sales are final.

 

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