Product name :PUMA

Catalog Number :000004A

Quantity :250ul

Price :621 Eur

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Supplier :ABM Goods

Alias BBC3
Protein Type Apoptosis Regulator / Mitochondrial
Protein Family Unknown
Functions PUMA is suggested to be a direct mediator of p53-associated apoptosis. It plays a role in mediating p53-induced cell death through the CytC/APAF1 dependent pathway. Exogenous expression of PUMA results in an extremely rapid and profound apoptosis that occurs much earlier than that resulting from exogenous expression of p53.
Cell Types Widely expressed
Protein Location Mitochondria
Chromosome 19q13.3-q13.4
Protein Structure PUMA encodes three BH3 domain-containing proteins, PUMA-Alpha, PUMA-Beta and PUMA-Delta, which are produced through the use of an alternative first exon and contain 193, 131 and 101 amino acids respectively.
Tags Ha
Gene Type Wild Type
Titer 1x106pfu/mL
Storage DMEM with 2.5% glycerol
Caution This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information.
Notes The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. All sales are final.

 

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