Search results for: 1-Amino Hydantoin-13C3 13C3H5N3O2 CAS: 957509-31-8
#32218360 2020/03/25 To Up
Synthesis of Pyrrolidine Monocyclic Analogues of Pochonicine and Its Stereoisomers: Pursuit ofSimplified Structures and Potent β--Acetylhexosaminidase Inhibition.
Ten pairs of pyrrolidine analogues of pochonicine and its stereoisomers have been synthesized from four enantiomeric pairs of polyhydroxylated cyclic nitrones. Among the ten N-acetylamino pyrrolidine analogues, only compounds with 2,5-dideoxy-2,5-imino-d-mannitol (DMDP) and pochonicine (1) configurations showed potent inhibition of β-N-acetylhexosaminidases (β-HexNAcases); while 1-amino analogues lost almost all their inhibitions towards the tested enzymes. The assay results reveal the importance of the -acetylamino group and the possible right configurations of pyrrolidine ring required for this type of inhibitors.Xin Yan, Yuna Shimadate, Atsushi Kato, Yi-Xian Li, Yue-Mei Jia, George W J Fleet, Chu-Yi Yu
2996 related Products with: Synthesis of Pyrrolidine Monocyclic Analogues of Pochonicine and Its Stereoisomers: Pursuit ofSimplified Structures and Potent β--Acetylhexosaminidase Inhibition.
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