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Search results for: 1-Bromo-2-ethylbenzene CAS: [1973-22-4]

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#38499468   2024/03/18 To Up

Optimizing Molecular Crystallinity and Suppressing Electron-Phonon Coupling in Completely Non-fused Ring Electron Acceptors for Organic Solar Cells.

High open-circuit voltage (VOC) organic solar cells (OSCs) have received increasing attention because of their promising application in tandem device and indoor photovoltaic. However, the lack of a precise correlation between molecular structure and stacking behaviors of wide bandgap electron acceptors has greatly limited its development. Here, we adopted an asymmetric halogenation strategy (AHS) and synthesized two completely non-fused ring electron acceptors (NFREAs), HF-BTA33 and HCl-BTA33. The results show that AHS significantly enhances the molecular dipoles and suppresses electron-phonon coupling, resulting in enhanced intramolecular/intermolecular interactions and decreased nonradiative decay. As a result, PTQ10:HF-BTA33 realizes a power conversion efficiency (PCE) of 11.42% with a VOC of 1.232 V, higher than that of symmetric analogue F-BTA33 (PCE=10.02%, VOC=1.197 V). Notably, PTQ10:HCl-BTA33 achieves the highest PCE of 12.54% with a VOC of 1.201 V due to the long-range ordered π-π packing and enhanced surface electrostatic interactions thereby facilitating exciton dissociation and charge transport. This work not only proves that asymmetric halogenation of completely NFREAs is a simple and effective strategy for achieving both high PCE and VOC, but also provides deeper insights for the precise molecular design of low cost completely NFREAs.
Tingting Dai, Ailing Tang, Yuhan Meng, Chuanqi Dong, Peiqing Cong, Jiahao Lu, Jimin Du, Yufei Zhong, Erjun Zhou

2826 related Products with: Optimizing Molecular Crystallinity and Suppressing Electron-Phonon Coupling in Completely Non-fused Ring Electron Acceptors for Organic Solar Cells.

2 ml96 tests1.00 flask 1 G-100 µg1x10e7 cells100ug Lyophilized96 wells1 mg1.00 flask

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#38499428   2024/02/29 To Up

Colorimetric and fluorescent independent dual "signal on" biosensor for accurate detection of ochratoxin A based on aptamer-triggered biocatalytic reactions.

Ochratoxin A (OTA) is a hazardous food contaminant with significant health risks. Dual-channel OTA detection is noted for its cross-reference capability and high accuracy. Still, challenges in addressing in-system corrections and "signal off" related false positives and limited signal gains remain. Herein, we developed a dual-channel "signal on" aptasensor with one recognition process and two independent signal outputs for OTA analysis. The OTA aptamer binds to magnetic beads (MBs) and partially hybridizes with a complementary-trigger (cDNA-Trigger) sequence. Adding OTA disrupts the duplex sequence, leading to G-quadruplex (G4) formation and enrichment on the MBs, which then interacts with hemin to catalyze a color signal. Concurrently, the freed cDNA-Trigger catalyzes an enzyme-free DNA circuit, producing a fluorescence signal. The magnetic enrichment and signal amplification strategies make the proposed assay demonstrate excellent sensitivity toward OTA, with limits of detection (LOD) of 0.017 pM in the fluorescence channel and 48.1 pM in the colorimetric channel. Both channels have effectively detected OTA in grape juice and baijiu, demonstrating their applicability and reliability. Moreover, given the widespread use of smartphones globally, a mini-program with a self-correction function was designed to facilitate on-site colorimetric channel monitoring, making OTA detection more accessible and user-friendly.
Hao Ding, Mingdi Zhang, Xiaochun Wang, Shuai He, Xiaokun Wang, Lingxin Chen

2239 related Products with: Colorimetric and fluorescent independent dual "signal on" biosensor for accurate detection of ochratoxin A based on aptamer-triggered biocatalytic reactions.

100tests100tests100tests100tests100tests100 reactions100tests100tests

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#38499123   2024/03/16 To Up

Rapid and sensitive detection of SARS-CoV-2 IgM through luciferase luminescence on an automatic platform.

SARS-CoV-2 has brought a global health crisis worldwide. IgM is an early marker in sera after the infections, and the detection of IgM is crucial to assist diagnosis and evaluate the vaccination clinically. Herein, we developed an automated platform to identify IgM against SARS-CoV-2 in sera. Streptavidin-magnetic beads were utilized to bind to a biotinylated anti-IgM antibody, which was employed to capture IgM in sera. RBD fused luciferase hGluc was employed to label the trapped IgM against RBD and the signal of luminescence of hGluc with the substrate of coelenterazine corresponded to the amount of SARS-CoV-2 IgM conjugated to the magnetic beads. An appropriate cut-off value of the designed method was defined by a set of negative samples and positive samples with 100 % sensitivity and 100 % specificity. Through serial dilution of a positive sample, it was found that the method has a better sensitivity than ELISA. The application to determine IgM against SARS-CoV-2 demonstrated a good performance of the method. The developed system can complete the analysis of SARS-CoV-2 IgM within 25 min. Through the substitution of RBD antigen with antigens of other pathogens in this platform, the automated detection of IgM against the corresponding pathogens can be realized.
Yibing Zhang, Yun Zhang, Wenhao Zhou, Ping He, Xueni Sun, Junhua Li, Hongping Wei, Junping Yu

2201 related Products with: Rapid and sensitive detection of SARS-CoV-2 IgM through luciferase luminescence on an automatic platform.

200ul10 mg200ul200ug200ug100 ul25ml 100ug Lyophilized200ul100ug Lyophilized25 mg200ul

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#38499094   2024/03/16 To Up

Sources of highly regional I in soils in northeast China.

The transport and deposition pathways of anthropogenic radionuclides at the global scale, particularly volatile I, remain somewhat elusive due to a dearth of comprehensive investigations. To gain a better understanding of the transport dynamics and deposition mechanism of anthropogenic I in the terrestrial environment, one hundred surface soil samples collected from northeast China were analyzed for I and I concentrations in this study. Our findings reveal that I/I atomic ratios in the mid-eastern Inner Mongolia (MIM) were approximately an order of magnitude higher than the rest of the investigated area. This is, besides the global fallout and the long-range transport of I released from the European nuclear reprocessing plants via westerly winds, possibly attributed to the dust with high I levels from the East Asian arid regions. In addition to the significant dust-induced I input, the unique meteorological conditions and topographical features in the MIM synergistically contribute to the pronounced accumulation and deposition of I in this region. This study will provide novel insights into the transport and deposition mechanism of anthropogenic radionuclides, which is significant for the assessment of anthropogenic nuclear activities on the environment in the future.
Yanyun Wang, Keliang Shi, Yukun Fan, Luyuan Zhang, Ning Chen, Qi Liu, Xiaolin Hou

1273 related Products with: Sources of highly regional I in soils in northeast China.

2 Pieces/Box4 Arrays/Slide4 Membranes/Box2 Pieces/Box4 Membranes/Box4 Membranes/Box2 Pieces/Box4 Arrays/Slide2 Pieces/Box4 Membranes/Box2 Pieces/Box4 Membranes/Box

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#38499092   2024/03/16 To Up

A supramolecular hydrogel dressing with antibacterial, immunoregulation, and pro-regeneration ability for biofilm-associated wound healing.

Chronic wound treatment has emerged as a significant healthcare concern worldwide due to its substantial economic burden and the limited effectiveness of current treatments. Effective management of biofilm infections, regulation of excessive oxidative stress, and promotion of tissue regeneration are crucial for addressing chronic wounds. Hydrogel stands out as a promising candidate for chronic wound treatment. However, its clinical application is hindered by the difficulty in designing and fabricating easily and conveniently. To overcome these obstacles, we present a supermolecular G-quadruplex hydrogel with the desired multifunction via a dynamic covalent strategy and Hoogsteen-type hydrogen bonding. The G-quadruplex hydrogel is made from the self-assembly of guanosine, 2-formylphenyboronic acid, polyethylenimine, and potassium chloride, employing dynamic covalent strategy and Hoogsteen-type hydrogen bonding. In the acidic/oxidative microenvironment associated with bacterial infections, the hydrogel undergoes controlled degradation, releasing the polyethylenimine domain, which effectively eliminates bacteria. Furthermore, nanocomplexes comprising guanosine monophosphate and manganese sulfate are incorporated into the hydrogel skeleton, endowing it with the ability to scavenge reactive oxygen species and modulate macrophages. Additionally, the integration of basic fibroblast growth factor into the G-quadruplex skeleton through dynamic covalent bonds facilitates controlled tissue regeneration. In summary, the facile preparation process and the incorporation of multiple functionalities render the G-quadruplex hydrogel a highly promising candidate for advanced wound dressing. It holds great potential to transition from laboratory research to clinical practice, addressing the pressing needs of chronic wound management.
Yumeng Wang, Xinghong Zhao, Xingjian Zhou, Juqin Dai, Xiaowen Hu, Yinzi Piao, Guangyue Zu, Jian Xiao, Keqing Shi, Yong Liu, Yuanfeng Li, Linqi Shi

1562 related Products with: A supramolecular hydrogel dressing with antibacterial, immunoregulation, and pro-regeneration ability for biofilm-associated wound healing.

0.1 mg10 mg1 g50 ug 25 µg100μg100ug100 assays100ul10ìg200ul

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#38498861   // To Up

Trueness of Crown Preparation Dies in Dental Models: An In Vitro Assessment of Digital and Analog Workflows.

To assess crown die trueness using additive manufacturing (AM) based on intraoral scanning (IOS) data and compare it with stone models.
Liudas Auskalnis, Mykolas Akulauskas, Darius Jegelevicius, Vygandas Rutkunas

1023 related Products with: Trueness of Crown Preparation Dies in Dental Models: An In Vitro Assessment of Digital and Analog Workflows.

96 tests1 ml100ug Lyophilized100 μg100 μg100 μg1 Set500 1 Set1 Set4 Membranes/Box1 Set

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#38498704   2024/03/18 To Up

Cip1, a CDK regulator, determines heterothallic mating or homothallic selfing in a protist.

Mating type (sex) plays a crucial role in regulating sexual reproduction in most extant eukaryotes. One of the functions of mating types is ensuring self-incompatibility to some extent, thereby promoting genetic diversity. However, heterothallic mating is not always the best mating strategy. For example, in low-density populations or specific environments, such as parasitic ones, species may need to increase the ratio of potential mating partners. Consequently, many species allow homothallic selfing (i.e., self-fertility or intraclonal mating). Throughout the extensive evolutionary history of species, changes in environmental conditions have influenced mating strategies back and forth. However, the mechanisms through which mating-type recognition regulates sexual reproduction and the dynamics of mating strategy throughout evolution remain poorly understood. In this study, we show that the Cip1 protein is responsible for coupling sexual reproduction initiation to mating-type recognition in the protozoal eukaryote . Deletion of the Cip1 protein leads to the loss of the selfing-avoidance function of mating-type recognition, resulting in selfing without mating-type recognition. Further experiments revealed that Cip1 is a regulatory subunit of the Cdk19-Cyc9 complex, which controls the initiation of sexual reproduction. These results reveal a mechanism that regulates the choice between mating and selfing. This mechanism also contributes to the debate about the ancestral state of sexual reproduction.
Yang Ma, Guanxiong Yan, Jing Zhang, Jie Xiong, Wei Miao

1743 related Products with: Cip1, a CDK regulator, determines heterothallic mating or homothallic selfing in a protist.

1 Set1 Set1 Set1 Set

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#38498525   2024/02/19 To Up

Purification Effect of Water Eutrophication Using the Mosaic System of Submerged-Emerged Plants and Growth Response.

Aquatic plants play a crucial role in the sustainable management of eutrophic water bodies, serving as a valuable tool for water purification. However, the effectiveness of using aquatic plants for improving water quality is influenced by landscape considerations. In practical applications, challenges arise concerning low purification efficiency and compromised aesthetic appeal when utilizing plants for water purification. To address these issues, this study aimed to examine the impact of aquatic plants on the purification of simulated landscape water bodies, specifically focusing on the effectiveness of the mosaic system of submerged-emerged plants in remediating eutrophic water bodies. Our findings indicated that individual aquatic plants exhibited limited efficacy in pollutant (total nitrogen, total phosphorus, ammonia nitrogen, and chemical oxygen demand) removal. However, when combined in appropriate proportions, submerged plants could enhance species growth and improve the purification efficiency of polluted water bodies. Notably, the mosaic system of submerged-emerged plants neither significantly promoted nor inhibited the growth of each other, but it effectively removed pollutants from the simulated water bodies and inhibited turbidity increase. The comprehensive evaluation ranked the purification capacity as -submerged plants combination (C + S) > -submerged plants combination (T + S) > -submerged plants combination (I + S) > -submerged plants combination (L + S). Both C + S and T + S configurations effectively mitigated the rise of water turbidity and offered appealing landscape benefits, making them viable options for practical applications in urban landscape water bodies. Our study highlights that a submerged-emerged mosaic combination is a means of water purification that combines landscape aesthetics and purification efficiency.
Baoliang Chang, Yingchun Xu, Ze Zhang, Xiaowen Wang, Qijiang Jin, Yanjie Wang

1274 related Products with: Purification Effect of Water Eutrophication Using the Mosaic System of Submerged-Emerged Plants and Growth Response.

5 G1 kit100.00 ug1 mg500 25 x 2 ml1120ug5ml0.1 mg

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#38498328   2024/03/18 To Up

Layer-by-layer nanoparticle encapsulating all-trans retinoic acid and CpG as a mucosal adjuvant targeting colorectal cancer.

Colorectal cancer (CRC) ranks among the most prevalent cancers globally, demanding innovative therapeutic strategies. Immunotherapy, a promising avenue, employs cancer vaccines to activate the immune system against tumors. However, conventional approaches fall short of eliciting robust responses within the gastrointestinal (GI) tract, where CRC originates. Harnessing the potential of all-trans retinoic acid (ATRA) and cytosine-phosphorothioate-guanine (CpG), we developed layered nanoparticles using a layer-by-layer assembly method to co-deliver these agents. ATRA, crucial for gut immunity, was efficiently encapsulated alongside CpG within these nanoparticles. Administering these ATRA@CpG-NPs, combined with ovalbumin peptide (OVA), effectively inhibited orthotopic CRC growth in mice. Our approach leveraged the inherent benefits of ATRA and CpG, demonstrating superior efficacy in activating dendritic cells, imprinting T cells with gut-homing receptors, and inhibiting tumor growth. This mucosal adjuvant presents a promising strategy for CRC immunotherapy, showcasing the potential for targeting gut-associated immune responses in combating colorectal malignancies.
Shiwei Mi, Wei Li, Yixing Wen, Chen Yang, Shuai Liu, Jingjiao Li, Xingdi Cheng, Yuanyuan Zhao, Haonan Huo, Haowei Zu, Xueguang Lu

2790 related Products with: Layer-by-layer nanoparticle encapsulating all-trans retinoic acid and CpG as a mucosal adjuvant targeting colorectal cancer.

1 G100ug Lyophilized 1 G96100100tests5 g1 g100tests100 assays100ug Lyophilized 1KG

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