Search results for: 2-Amino-3-chloro-N-hydroxy-propanamide C3H7ClN2O2 CAS: 120854-55-9
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#38499428 2024/02/29 To Up
Colorimetric and fluorescent independent dual "signal on" biosensor for accurate detection of ochratoxin A based on aptamer-triggered biocatalytic reactions.
Ochratoxin A (OTA) is a hazardous food contaminant with significant health risks. Dual-channel OTA detection is noted for its cross-reference capability and high accuracy. Still, challenges in addressing in-system corrections and "signal off" related false positives and limited signal gains remain. Herein, we developed a dual-channel "signal on" aptasensor with one recognition process and two independent signal outputs for OTA analysis. The OTA aptamer binds to magnetic beads (MBs) and partially hybridizes with a complementary-trigger (cDNA-Trigger) sequence. Adding OTA disrupts the duplex sequence, leading to G-quadruplex (G4) formation and enrichment on the MBs, which then interacts with hemin to catalyze a color signal. Concurrently, the freed cDNA-Trigger catalyzes an enzyme-free DNA circuit, producing a fluorescence signal. The magnetic enrichment and signal amplification strategies make the proposed assay demonstrate excellent sensitivity toward OTA, with limits of detection (LOD) of 0.017 pM in the fluorescence channel and 48.1 pM in the colorimetric channel. Both channels have effectively detected OTA in grape juice and baijiu, demonstrating their applicability and reliability. Moreover, given the widespread use of smartphones globally, a mini-program with a self-correction function was designed to facilitate on-site colorimetric channel monitoring, making OTA detection more accessible and user-friendly.Hao Ding, Mingdi Zhang, Xiaochun Wang, Shuai He, Xiaokun Wang, Lingxin Chen
2915 related Products with: Colorimetric and fluorescent independent dual "signal on" biosensor for accurate detection of ochratoxin A based on aptamer-triggered biocatalytic reactions.
100tests100tests100tests100tests100tests100 reactions100tests100testsRelated Pathways
#38499123 2024/03/16 To Up
Rapid and sensitive detection of SARS-CoV-2 IgM through luciferase luminescence on an automatic platform.
SARS-CoV-2 has brought a global health crisis worldwide. IgM is an early marker in sera after the infections, and the detection of IgM is crucial to assist diagnosis and evaluate the vaccination clinically. Herein, we developed an automated platform to identify IgM against SARS-CoV-2 in sera. Streptavidin-magnetic beads were utilized to bind to a biotinylated anti-IgM antibody, which was employed to capture IgM in sera. RBD fused luciferase hGluc was employed to label the trapped IgM against RBD and the signal of luminescence of hGluc with the substrate of coelenterazine corresponded to the amount of SARS-CoV-2 IgM conjugated to the magnetic beads. An appropriate cut-off value of the designed method was defined by a set of negative samples and positive samples with 100 % sensitivity and 100 % specificity. Through serial dilution of a positive sample, it was found that the method has a better sensitivity than ELISA. The application to determine IgM against SARS-CoV-2 demonstrated a good performance of the method. The developed system can complete the analysis of SARS-CoV-2 IgM within 25 min. Through the substitution of RBD antigen with antigens of other pathogens in this platform, the automated detection of IgM against the corresponding pathogens can be realized.Yibing Zhang, Yun Zhang, Wenhao Zhou, Ping He, Xueni Sun, Junhua Li, Hongping Wei, Junping Yu
2213 related Products with: Rapid and sensitive detection of SARS-CoV-2 IgM through luciferase luminescence on an automatic platform.
200ul10 mg200ul200ug200ug100ul200ul25 mg100 ul25ml 200ul100ug LyophilizedRelated Pathways
#38498704 2024/03/18 To Up
Cip1, a CDK regulator, determines heterothallic mating or homothallic selfing in a protist.
Mating type (sex) plays a crucial role in regulating sexual reproduction in most extant eukaryotes. One of the functions of mating types is ensuring self-incompatibility to some extent, thereby promoting genetic diversity. However, heterothallic mating is not always the best mating strategy. For example, in low-density populations or specific environments, such as parasitic ones, species may need to increase the ratio of potential mating partners. Consequently, many species allow homothallic selfing (i.e., self-fertility or intraclonal mating). Throughout the extensive evolutionary history of species, changes in environmental conditions have influenced mating strategies back and forth. However, the mechanisms through which mating-type recognition regulates sexual reproduction and the dynamics of mating strategy throughout evolution remain poorly understood. In this study, we show that the Cip1 protein is responsible for coupling sexual reproduction initiation to mating-type recognition in the protozoal eukaryote . Deletion of the Cip1 protein leads to the loss of the selfing-avoidance function of mating-type recognition, resulting in selfing without mating-type recognition. Further experiments revealed that Cip1 is a regulatory subunit of the Cdk19-Cyc9 complex, which controls the initiation of sexual reproduction. These results reveal a mechanism that regulates the choice between mating and selfing. This mechanism also contributes to the debate about the ancestral state of sexual reproduction.Yang Ma, Guanxiong Yan, Jing Zhang, Jie Xiong, Wei Miao
1733 related Products with: Cip1, a CDK regulator, determines heterothallic mating or homothallic selfing in a protist.
1 Set1 Set1 Set1 Set1 SetRelated Pathways
#38499173 2024/03/16 To Up
Ozone and its precursors at an urban site in the Yangtze River Delta since clean air action plan phase II in China.
In response to regional ozone (O) pollution, Chinese government has implemented air pollution control measures in recent years. Here, a case study was performed at an O-polluted city, Wuhu, in Yangtze River Delta region of China to investigate O variation trend and the relationship to its precursors after implementation of Clean Air Action Plan Phase II, which aims to reduce O pollution. The results showed that peak O concentration was effectively reduced since Clean Air Action Plan Phase II. Due to significant NOx reduction, O formation tended to shift from volatile organic compound (VOC)-limited regimes to NOx-limited regimes during 2018-2022. VOC/NOx ratios measured in 2022 revealed that peak O concentration tended to respond positively to NOx. Apart from high-O period, Wuhu was still in a VOC-limited regime. The relationship of maximum daily 8-h ozone average and NO followed a lognormal distribution with an inflection point at 20 μg m of NO, suggesting that Wuhu should conduct joint control of VOC and NOx with a focus on VOC reduction before the inflection point. Alkenes and aromatics were suggested to be preferentially controlled due to their higher ozone formation potentials. Using random forest meteorological normalization method, meteorology had a positive effect on O concentration in 2018, 2019 and 2022, but a negative effect in 2020 and 2021. The meteorology could explain 44.0 ± 19.1% of the O variation during 2018-2022. High temperature favors O production and O pollution occurred more easily when temperature was over 25 °C, while high relative humidity inhibits O generation and no O pollution was found at relative humidity above 70%. This study unveils some new insights into the trend of urban O pollution in Yangtze River Delta region since Clean Air Action Plan Phase II and the findings provide important references for formulating control strategies against O pollution.Hua Fang, Wenjing Wang, Ran Wang, Hongling Xu, Ying Zhang, Ting Wu, Ruicheng Zhou, Jianxi Zhang, Zhirong Ruan, Feng Li, Xinming Wang
1066 related Products with: Ozone and its precursors at an urban site in the Yangtze River Delta since clean air action plan phase II in China.
1 Set100 μg1 Set100 μg100 μg100 μg100 μg100 μgRelated Pathways
#38499094 2024/03/16 To Up
Sources of highly regional I in soils in northeast China.
The transport and deposition pathways of anthropogenic radionuclides at the global scale, particularly volatile I, remain somewhat elusive due to a dearth of comprehensive investigations. To gain a better understanding of the transport dynamics and deposition mechanism of anthropogenic I in the terrestrial environment, one hundred surface soil samples collected from northeast China were analyzed for I and I concentrations in this study. Our findings reveal that I/I atomic ratios in the mid-eastern Inner Mongolia (MIM) were approximately an order of magnitude higher than the rest of the investigated area. This is, besides the global fallout and the long-range transport of I released from the European nuclear reprocessing plants via westerly winds, possibly attributed to the dust with high I levels from the East Asian arid regions. In addition to the significant dust-induced I input, the unique meteorological conditions and topographical features in the MIM synergistically contribute to the pronounced accumulation and deposition of I in this region. This study will provide novel insights into the transport and deposition mechanism of anthropogenic radionuclides, which is significant for the assessment of anthropogenic nuclear activities on the environment in the future.Yanyun Wang, Keliang Shi, Yukun Fan, Luyuan Zhang, Ning Chen, Qi Liu, Xiaolin Hou
1781 related Products with: Sources of highly regional I in soils in northeast China.
4 Arrays/Slide4 Membranes/Box2 Pieces/Box4 Membranes/Box2 Pieces/Box2 Pieces/Box4 Arrays/Slide2 Pieces/Box4 Membranes/Box2 Pieces/Box4 Membranes/Box4 Membranes/BoxRelated Pathways
#38499092 2024/03/16 To Up
A supramolecular hydrogel dressing with antibacterial, immunoregulation, and pro-regeneration ability for biofilm-associated wound healing.
CYumeng Wang, Xinghong Zhao, Xingjian Zhou, Juqin Dai, Xiaowen Hu, Yinzi Piao, Guangyue Zu, Jian Xiao, Keqing Shi, Yong Liu, Yuanfeng Li, Linqi Shi
1529 related Products with: A supramolecular hydrogel dressing with antibacterial, immunoregulation, and pro-regeneration ability for biofilm-associated wound healing.
25 µg10 mg1 g50 ug 100μg100ug0.1 mg10ìg100 assays200ulRelated Pathways
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#38498861 // To Up
Trueness of Crown Preparation Dies in Dental Models: An In Vitro Assessment of Digital and Analog Workflows.
To assess crown die trueness using additive manufacturing (AM) based on intraoral scanning (IOS) data and compare it with stone models.Liudas Auskalnis, Mykolas Akulauskas, Darius Jegelevicius, Vygandas Rutkunas
1123 related Products with: Trueness of Crown Preparation Dies in Dental Models: An In Vitro Assessment of Digital and Analog Workflows.
96 tests1 ml1 Set1 Set100 μg1 Set100 μg1 Set100 μg100 μg10 100 μgRelated Pathways
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#38498525 2024/02/19 To Up
Purification Effect of Water Eutrophication Using the Mosaic System of Submerged-Emerged Plants and Growth Response.
Aquatic plants play a crucial role in the sustainable management of eutrophic water bodies, serving as a valuable tool for water purification. However, the effectiveness of using aquatic plants for improving water quality is influenced by landscape considerations. In practical applications, challenges arise concerning low purification efficiency and compromised aesthetic appeal when utilizing plants for water purification. To address these issues, this study aimed to examine the impact of aquatic plants on the purification of simulated landscape water bodies, specifically focusing on the effectiveness of the mosaic system of submerged-emerged plants in remediating eutrophic water bodies. Our findings indicated that individual aquatic plants exhibited limited efficacy in pollutant (total nitrogen, total phosphorus, ammonia nitrogen, and chemical oxygen demand) removal. However, when combined in appropriate proportions, submerged plants could enhance species growth and improve the purification efficiency of polluted water bodies. Notably, the mosaic system of submerged-emerged plants neither significantly promoted nor inhibited the growth of each other, but it effectively removed pollutants from the simulated water bodies and inhibited turbidity increase. The comprehensive evaluation ranked the purification capacity as -submerged plants combination (C + S) > -submerged plants combination (T + S) > -submerged plants combination (I + S) > -submerged plants combination (L + S). Both C + S and T + S configurations effectively mitigated the rise of water turbidity and offered appealing landscape benefits, making them viable options for practical applications in urban landscape water bodies. Our study highlights that a submerged-emerged mosaic combination is a means of water purification that combines landscape aesthetics and purification efficiency.Baoliang Chang, Yingchun Xu, Ze Zhang, Xiaowen Wang, Qijiang Jin, Yanjie Wang
1650 related Products with: Purification Effect of Water Eutrophication Using the Mosaic System of Submerged-Emerged Plants and Growth Response.
5 G1 mg500 25 x 2 ml1120ug5ml0.1 mg100 µg4 Sample Kit1 mlRelated Pathways
#38498328 2024/03/18 To Up
Layer-by-layer nanoparticle encapsulating all-trans retinoic acid and CpG as a mucosal adjuvant targeting colorectal cancer.
CShiwei Mi, Wei Li, Yixing Wen, Chen Yang, Shuai Liu, Jingjiao Li, Xingdi Cheng, Yuanyuan Zhao, Haonan Huo, Haowei Zu, Xueguang Lu
2737 related Products with: Layer-by-layer nanoparticle encapsulating all-trans retinoic acid and CpG as a mucosal adjuvant targeting colorectal cancer.
1 G100ug Lyophilized 1 G100100tests965 g1 g100 assays100tests100ug Lyophilized 100 GRelated Pathways
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