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Search results for: 2-Amino-5-bromo-3-pyridinemethanol C6H7BrN2O CAS: 335031-01-1

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#38499428   2024/02/29 To Up

Colorimetric and fluorescent independent dual "signal on" biosensor for accurate detection of ochratoxin A based on aptamer-triggered biocatalytic reactions.

Ochratoxin A (OTA) is a hazardous food contaminant with significant health risks. Dual-channel OTA detection is noted for its cross-reference capability and high accuracy. Still, challenges in addressing in-system corrections and "signal off" related false positives and limited signal gains remain. Herein, we developed a dual-channel "signal on" aptasensor with one recognition process and two independent signal outputs for OTA analysis. The OTA aptamer binds to magnetic beads (MBs) and partially hybridizes with a complementary-trigger (cDNA-Trigger) sequence. Adding OTA disrupts the duplex sequence, leading to G-quadruplex (G4) formation and enrichment on the MBs, which then interacts with hemin to catalyze a color signal. Concurrently, the freed cDNA-Trigger catalyzes an enzyme-free DNA circuit, producing a fluorescence signal. The magnetic enrichment and signal amplification strategies make the proposed assay demonstrate excellent sensitivity toward OTA, with limits of detection (LOD) of 0.017 pM in the fluorescence channel and 48.1 pM in the colorimetric channel. Both channels have effectively detected OTA in grape juice and baijiu, demonstrating their applicability and reliability. Moreover, given the widespread use of smartphones globally, a mini-program with a self-correction function was designed to facilitate on-site colorimetric channel monitoring, making OTA detection more accessible and user-friendly.
Hao Ding, Mingdi Zhang, Xiaochun Wang, Shuai He, Xiaokun Wang, Lingxin Chen

2505 related Products with: Colorimetric and fluorescent independent dual "signal on" biosensor for accurate detection of ochratoxin A based on aptamer-triggered biocatalytic reactions.

100tests100tests100tests100tests100tests100 reactions100tests100tests

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#38499173   2024/03/16 To Up

Ozone and its precursors at an urban site in the Yangtze River Delta since clean air action plan phase II in China.

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Hua Fang, Wenjing Wang, Ran Wang, Hongling Xu, Ying Zhang, Ting Wu, Ruicheng Zhou, Jianxi Zhang, Zhirong Ruan, Feng Li, Xinming Wang

2850 related Products with: Ozone and its precursors at an urban site in the Yangtze River Delta since clean air action plan phase II in China.

1 Set100 μg1 Set100 μg100 μg100 μg100 μg100 μg

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#38499123   2024/03/16 To Up

Rapid and sensitive detection of SARS-CoV-2 IgM through luciferase luminescence on an automatic platform.

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Yibing Zhang, Yun Zhang, Wenhao Zhou, Ping He, Xueni Sun, Junhua Li, Hongping Wei, Junping Yu

1427 related Products with: Rapid and sensitive detection of SARS-CoV-2 IgM through luciferase luminescence on an automatic platform.

200ul10 mg200ul200ug200ug100 ul25ml 100ug Lyophilized200ul100ug Lyophilized25 mg200ul

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#38499094   2024/03/16 To Up

Sources of highly regional I in soils in northeast China.

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Yanyun Wang, Keliang Shi, Yukun Fan, Luyuan Zhang, Ning Chen, Qi Liu, Xiaolin Hou

2487 related Products with: Sources of highly regional I in soils in northeast China.

2 Pieces/Box4 Arrays/Slide4 Membranes/Box2 Pieces/Box4 Membranes/Box4 Membranes/Box2 Pieces/Box4 Arrays/Slide2 Pieces/Box4 Membranes/Box2 Pieces/Box4 Membranes/Box

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#38499092   2024/03/16 To Up

A supramolecular hydrogel dressing with antibacterial, immunoregulation, and pro-regeneration ability for biofilm-associated wound healing.

Chronic wound treatment has emerged as a significant healthcare concern worldwide due to its substantial economic burden and the limited effectiveness of current treatments. Effective management of biofilm infections, regulation of excessive oxidative stress, and promotion of tissue regeneration are crucial for addressing chronic wounds. Hydrogel stands out as a promising candidate for chronic wound treatment. However, its clinical application is hindered by the difficulty in designing and fabricating easily and conveniently. To overcome these obstacles, we present a supermolecular G-quadruplex hydrogel with the desired multifunction via a dynamic covalent strategy and Hoogsteen-type hydrogen bonding. The G-quadruplex hydrogel is made from the self-assembly of guanosine, 2-formylphenyboronic acid, polyethylenimine, and potassium chloride, employing dynamic covalent strategy and Hoogsteen-type hydrogen bonding. In the acidic/oxidative microenvironment associated with bacterial infections, the hydrogel undergoes controlled degradation, releasing the polyethylenimine domain, which effectively eliminates bacteria. Furthermore, nanocomplexes comprising guanosine monophosphate and manganese sulfate are incorporated into the hydrogel skeleton, endowing it with the ability to scavenge reactive oxygen species and modulate macrophages. Additionally, the integration of basic fibroblast growth factor into the G-quadruplex skeleton through dynamic covalent bonds facilitates controlled tissue regeneration. In summary, the facile preparation process and the incorporation of multiple functionalities render the G-quadruplex hydrogel a highly promising candidate for advanced wound dressing. It holds great potential to transition from laboratory research to clinical practice, addressing the pressing needs of chronic wound management.
Yumeng Wang, Xinghong Zhao, Xingjian Zhou, Juqin Dai, Xiaowen Hu, Yinzi Piao, Guangyue Zu, Jian Xiao, Keqing Shi, Yong Liu, Yuanfeng Li, Linqi Shi

2360 related Products with: A supramolecular hydrogel dressing with antibacterial, immunoregulation, and pro-regeneration ability for biofilm-associated wound healing.

0.1 mg10 mg1 g50 ug 25 µg100μg100ug100 assays100ul10ìg200ul

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#38498861   // To Up

Trueness of Crown Preparation Dies in Dental Models: An In Vitro Assessment of Digital and Analog Workflows.

To assess crown die trueness using additive manufacturing (AM) based on intraoral scanning (IOS) data and compare it with stone models.
Liudas Auskalnis, Mykolas Akulauskas, Darius Jegelevicius, Vygandas Rutkunas

1238 related Products with: Trueness of Crown Preparation Dies in Dental Models: An In Vitro Assessment of Digital and Analog Workflows.

96 tests1 ml100ug Lyophilized100 μg100 μg100 μg1 Set500 1 Set1 Set4 Membranes/Box1 Set

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#38498704   2024/03/18 To Up

Cip1, a CDK regulator, determines heterothallic mating or homothallic selfing in a protist.

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Yang Ma, Guanxiong Yan, Jing Zhang, Jie Xiong, Wei Miao

2864 related Products with: Cip1, a CDK regulator, determines heterothallic mating or homothallic selfing in a protist.

1 Set1 Set1 Set1 Set

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#38498525   2024/02/19 To Up

Purification Effect of Water Eutrophication Using the Mosaic System of Submerged-Emerged Plants and Growth Response.

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Baoliang Chang, Yingchun Xu, Ze Zhang, Xiaowen Wang, Qijiang Jin, Yanjie Wang

1160 related Products with: Purification Effect of Water Eutrophication Using the Mosaic System of Submerged-Emerged Plants and Growth Response.

5 G1 kit100.00 ug1 mg500 25 x 2 ml1120ug5ml0.1 mg

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#38498328   2024/03/18 To Up

Layer-by-layer nanoparticle encapsulating all-trans retinoic acid and CpG as a mucosal adjuvant targeting colorectal cancer.

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Shiwei Mi, Wei Li, Yixing Wen, Chen Yang, Shuai Liu, Jingjiao Li, Xingdi Cheng, Yuanyuan Zhao, Haonan Huo, Haowei Zu, Xueguang Lu

2642 related Products with: Layer-by-layer nanoparticle encapsulating all-trans retinoic acid and CpG as a mucosal adjuvant targeting colorectal cancer.

1 G100ug Lyophilized 1 G96100100tests5 g1 g100tests100 assays100ug Lyophilized 1KG

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