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Activation pattern of signal transducers and activators of transcription (STAT) factors in inflammatory bowel diseases.

Cytokine signaling pathways involving transcription factors of the signal transducers and activators of transcription (STAT) family play a key role in the pathogenesis of inflammatory bowel diseases (IBD). STAT proteins are latent cytoplasmic transcription factors that induce transcription upon phosphorylation, dimerization, and nuclear translocation. However, their activation pattern in IBD is poorly understood. The aim of our study was to characterize STAT-expression in IBD.
Jonas Mudter, Benno Weigmann, Brigitte Bartsch, Ralf Kiesslich, Dennis Strand, Peter R Galle, Hans A Lehr, Jan Schmidt, Markus F Neurath

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