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Search results for: 5-Acetoxy-3-chloro-2-pentanone C7H11ClO3 CAS: 13051-49-5

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#38500822   2024/03/01 To Up

High-frequency neural activity dysregulation is associated with sleep and psychiatric disorders in BMAL1-deficient animal models.

Sleep disturbance led by BMAL1-deficiency has been recognized both in rodent and non-human primate models. Yet it remained unclear how their diurnal brain oscillations were affected upon BMAL1 ablation and what caused the discrepancy in the quantity of sleep between the two species. Here, we investigated diurnal electroencephalographs of BMAL1-deficient mice and cynomolgus monkeys at young adult age and uncovered a shared defect of dysregulated high-frequency oscillations by Kullback-Leibler divergence analysis. We found beta and gamma oscillations were significantly disturbed in a day versus night manner in BMAL1-deficient monkeys, while in mice the beta band difference was less evident. Notably, the dysregulation of beta oscillations was particularly associated with psychiatric behaviors in BMAL1-deficient monkeys, including the occurrence of self-injuring and delusion-like actions. As such psychiatric phenotypes were challenging to uncover in rodent models, our results offered a unique method to study the correlation between circadian clock dysregulation and psychiatric disorders.
Yu Sun, Mingzhu Zhong, Niannian Xu, Xueting Zhang, Huanhuan Sun, Yan Wang, Yong Lu, Yanhong Nie, Qing Li, Qiang Sun, Jian Jiang, Yun-Chi Tang, Hung-Chun Chang

1533 related Products with: High-frequency neural activity dysregulation is associated with sleep and psychiatric disorders in BMAL1-deficient animal models.

400Tests900 tests0.1ml (1mg/ml)100ug Lyophilized100ug Lyophilized96 assays 100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized

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#38500582   2024/03/04 To Up

Normal distribution of H3K9me3 occupancy co-mediated by histone methyltransferase BcDIM5 and histone deacetylase BcHda1 maintains stable ABA synthesis in TB-31.

Abscisic acid (ABA) is a conserved and important "sesquiterpene signaling molecule" widely distributed in different organisms with unique biological functions. ABA coordinates reciprocity and competition between microorganisms and their hosts. In addition, ABA also regulates immune and stress responses in plants and animals. Therefore, ABA has a wide range of applications in agriculture, medicine and related fields. The plant pathogenic ascomycete has been extensively studied as a model strain for ABA production. Nevertheless, there is a relative dearth of research regarding the regulatory mechanism governing ABA biosynthesis in . Here, we discovered that H3K9 methyltransferase BcDIM5 is physically associated with the H3K14 deacetylase BcHda1. Deletion of and in the high ABA-producing TB-31 led to severe impairment of ABA synthesis. The combined analysis of RNA-seq and ChIP-seq has revealed that the absence of BcDIM5 and BcHda1 has resulted in significant global deficiencies in the normal distribution and level of H3K9me3 modification. In addition, we found that the cause of the decreased ABA production in the Δ and Δ mutants was due to cluster gene repression caused by the emergence of hyper-H3K9me3 in the ABA gene cluster. We concluded that the ABA gene cluster is co-regulated by BcDIM5 and BcHda1, which are essential for the normal distribution of the TB-31 ABA gene cluster H3K9me3. This work expands our understanding of the complex regulatory network of ABA biosynthesis and provides a theoretical basis for genetic improvement of high-yielding ABA strains.
Zhao Wei, Dan Shu, Xiaonan Hou, Tianfu Li, Zhemin Li, Di Luo, Jie Yang, Hong Tan

1550 related Products with: Normal distribution of H3K9me3 occupancy co-mediated by histone methyltransferase BcDIM5 and histone deacetylase BcHda1 maintains stable ABA synthesis in TB-31.

48 assays 96 assays 48 assays 96 assays 48 assays 96 assays 5mg5mg50 ug10mg100 µg10mg

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#38500015   // To Up

The dual roles of dissimilatory iron reduction in the carbon cycle: The "iron mesh" effect can increase inorganic carbon sequestration.

Dissimilatory iron reduction (DIR) can drive the release of organic carbon (OC) as carbon dioxide (CO ) by mediating electron transfer between organic compounds and microbes. However, DIR is also crucial for carbon sequestration, which can affect inorganic-carbon redistribution via iron abiotic-phase transformation. The formation conditions of modern carbonate-bearing iron minerals (IC ) and their potential as a CO sink are still unclear. A natural environment with modern IC , such as karst lake sediment, could be a good analog to explore the regulation of microbial iron reduction and sequential mineral formation. We find that high porosity is conducive to electron transport and dissimilatory iron-reducing bacteria activity, which can increase the iron reduction rate. The iron-rich environment with high calcium and OC can form a large sediment pore structure to support rapid DIR, which is conducive to the formation and growth of IC . Our results further demonstrate that the minimum DIR threshold suitable for IC formation is 6.65 μmol g  dw day . DIR is the dominant pathway (average 66.93%) of organic anaerobic mineralization, and the abiotic-phase transformation of Fe reduces CO emissions by ~41.79%. Our findings indicate that as part of the carbon cycle, DIR not only drives mineralization reactions but also traps carbon, increasing the stability of carbon sinks. Considering the wide geographic distribution of DIR and IC , our findings suggest that the "iron mesh" effect may become an increasingly important vector of carbon sequestration.
Cheng Zhao, Fan Xun, Biao Li, Xiaotong Han, Huan Liu, Yingxun Du, Qinglong L Wu, Peng Xing

1300 related Products with: The dual roles of dissimilatory iron reduction in the carbon cycle: The "iron mesh" effect can increase inorganic carbon sequestration.

1 25 G

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#38499798   2024/03/18 To Up

International nomenclature guidelines for the IL-1 family of cytokines and receptors.


Joseph M Gaballa, Jesper Falkesgaard Højen, Dennis M De Graaf, Jesus Amo-Aparicio, Carlo Marchetti, Giulio Cavalli, Alberto Dinarello, Suzhao Li, Michaele Francesco Corbisiero, Isak W Tengesdal, Jasmina S Redzic, Tania Azam, William S Webber, Karl A Pankratz, Makenna J May, Fabio Cominelli, Elan Z Eisenmesser, Soohyun Kim, Charles A Dinarello, Diana Boraschi

1213 related Products with: International nomenclature guidelines for the IL-1 family of cytokines and receptors.

1 g100ug100μg100 mg 100ul 100ul100ug100ug Lyophilized100ug100ug Lyophilized100ul100ug

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#38499771   2024/03/18 To Up

Decomposition of an odorant in olfactory perception and neural representation.

Molecules-the elementary units of substances-are commonly considered the units of processing in olfactory perception, giving rise to undifferentiated odour objects invariant to environmental variations. By selectively perturbing the processing of chemical substructures with adaptation ('the psychologist's microelectrode') in a series of psychophysical and neuroimaging experiments (458 participants), we show that two perceptually distinct odorants sharing part of their structural features become significantly less discernible following adaptation to a third odorant containing their non-shared structural features, in manners independent of olfactory intensity, valence, quality or general olfactory adaptation. The effect is accompanied by reorganizations of ensemble activity patterns in the posterior piriform cortex that parallel subjective odour quality changes, in addition to substructure-based neural adaptations in the anterior piriform cortex and amygdala. Central representations of odour quality and the perceptual outcome thus embed submolecular structural information and are malleable by recent olfactory encounters.
Yuting Ye, Yanqing Wang, Yuan Zhuang, Huibang Tan, Zhentao Zuo, Hanqi Yun, Kaiqi Yuan, Wen Zhou

1778 related Products with: Decomposition of an odorant in olfactory perception and neural representation.

100ug Lyophilized100 μg1 Set1 Set1 Set100ug100ug Lyophilized1 Set1000 TESTS/0.65ml100ug Lyophilized0.1ml (1mg/ml)100 μg

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#38499468   2024/03/18 To Up

Optimizing Molecular Crystallinity and Suppressing Electron-Phonon Coupling in Completely Non-fused Ring Electron Acceptors for Organic Solar Cells.

High open-circuit voltage (VOC) organic solar cells (OSCs) have received increasing attention because of their promising application in tandem device and indoor photovoltaic. However, the lack of a precise correlation between molecular structure and stacking behaviors of wide bandgap electron acceptors has greatly limited its development. Here, we adopted an asymmetric halogenation strategy (AHS) and synthesized two completely non-fused ring electron acceptors (NFREAs), HF-BTA33 and HCl-BTA33. The results show that AHS significantly enhances the molecular dipoles and suppresses electron-phonon coupling, resulting in enhanced intramolecular/intermolecular interactions and decreased nonradiative decay. As a result, PTQ10:HF-BTA33 realizes a power conversion efficiency (PCE) of 11.42% with a VOC of 1.232 V, higher than that of symmetric analogue F-BTA33 (PCE=10.02%, VOC=1.197 V). Notably, PTQ10:HCl-BTA33 achieves the highest PCE of 12.54% with a VOC of 1.201 V due to the long-range ordered π-π packing and enhanced surface electrostatic interactions thereby facilitating exciton dissociation and charge transport. This work not only proves that asymmetric halogenation of completely NFREAs is a simple and effective strategy for achieving both high PCE and VOC, but also provides deeper insights for the precise molecular design of low cost completely NFREAs.
Tingting Dai, Ailing Tang, Yuhan Meng, Chuanqi Dong, Peiqing Cong, Jiahao Lu, Jimin Du, Yufei Zhong, Erjun Zhou

2501 related Products with: Optimizing Molecular Crystallinity and Suppressing Electron-Phonon Coupling in Completely Non-fused Ring Electron Acceptors for Organic Solar Cells.

2 ml96 tests1.00 flask 1 G-100 µg1x10e7 cells100ug Lyophilized96 wells1 mg1.00 flask

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