Search results for: 5-Aminoimidazole-4-carboxamide-1-β-D-Ribofuranosyl 5’-Monophosphate C9H15N4O8P CAS: 3031-94-5
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Symptomatic Retinal Artery Occlusion after Angioplasty and Stenting of the Carotid Artery: Incidence and Related Risk Factors.Retinal artery occlusion (RAO) is rarely seen as a complication in patients undergoing carotid artery stenting (CAS); hence, its characteristics have not been documented in detail. This study aimed to investigate the incidence of this complication and the related risk factors, focusing on differences in ophthalmic artery (OA) supply (whether by the external or internal carotid artery [ECA or ICA]) prior to CAS procedures.
2327 related Products with: Symptomatic Retinal Artery Occlusion after Angioplasty and Stenting of the Carotid Artery: Incidence and Related Risk Factors.Androgen Receptor (5α)-2'H-Androst-2-eno[3 (3β)-Androsta-5,16-diene (5α)-Androstane-3,11,17- Androstane 3a,17b diol Gl Uterine Cervix Cancer of Bovine Androstenedione,AS Rabbit Anti-Human Androge Anti-Androgen Receptor pr Androgen Receptor , Mouse (5α,16β)-N-Acetyl-16-ac GFP Expressing Human Aort
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Catch Me If You Can: A Spatial Model for a Brake-Driven Gene Drive Reversal.Population management using artificial gene drives (alleles biasing inheritance, increasing their own transmission to offspring) is becoming a realistic possibility with the development of CRISPR-Cas genetic engineering. A gene drive may, however, have to be stopped. "Antidotes" (brakes) have been suggested, but have been so far only studied in well-mixed populations. Here, we consider a reaction-diffusion system modeling the release of a gene drive (of fitness [Formula: see text]) and a brake (fitness [Formula: see text], [Formula: see text]) in a wild-type population (fitness 1). We prove that whenever the drive fitness is at most 1/2 while the brake fitness is close to 1, coextinction of the brake and the drive occurs in the long run. On the contrary, if the drive fitness is greater than 1/2, then coextinction is impossible: the drive and the brake keep spreading spatially, leaving in the invasion wake a complicated spatiotemporally heterogeneous genetic pattern. Based on numerical experiments, we argue in favor of a global coextinction conjecture provided the drive fitness is at most 1/2, irrespective of the brake fitness. The proof relies upon the study of a related predator-prey system with strong Allee effect on the prey. Our results indicate that some drives may be unstoppable and that if gene drives are ever deployed in nature, threshold drives, that only spread if introduced in high enough frequencies, should be preferred.
2816 related Products with: Catch Me If You Can: A Spatial Model for a Brake-Driven Gene Drive Reversal.N-γ-Acetyl-N-2-formyl-5- 6-Amino-1-benzyl-5-(N-for 5-Acetylamino-6-formylami Anti CEL Monoclonal Antib Cell Meter™ Generic Flu DNA (cytosine 5) methyltr MarkerGeneTM Fluorescent 5-Acetyl-d3-amino-6-formy Anti- ADAM-12 (A Disintig 6-Amino-5-(N-formyl-N-met PERMANENT AQUEOUS MOUNTIN Anti-ADAMTS-13 (A Disinti
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Depression recognition using machine learning methods with different feature generation strategies.The diagnosis of depression almost exclusively depends on doctor-patient communication and scale analysis, which have the obvious disadvantages such as patient denial, poor sensitivity, subjective biases and inaccuracy. An objective, automated method that predicts clinical outcomes in depression is essential for increasing the accuracy of depression recognition and treatments. This paper aims at better recognizing depression using the transformation of EEG features and machine learning methods. An experiment based on emotional face stimuli task was conducted, and twenty-eight subjects' EEG data were recorded from 128-channel HydroCel Geodesic Sensor Net (HCGSN) by Net Station software. The Mini International Neuropsychiatric Interview (MINI) was used by psychiatrists as the criterion for diagnosis of depression patients. The power spectral density and activity were respectively extracted as original features using Auto-regress model and Hjorth algorithm with different time windows. Two separate approaches processed the features: ensemble learning and deep learning. For the ensemble learning, a deep forest transformed the original features to new features that potentially improve feature engineering and a support vector machine (SVM) that was applied as classifier. For deep learning method, we added spatial information of EEG caps to both features by image conversion and adopted convolutional neural network (CNN) to recognize them. The performance of both methods was evaluated for separated and total frequency bands. As a result, the best accuracy obtained was 89.02% when we used the ensemble model and power spectral density. The best accuracy of deep learning method was 84.75% using the activity. These experimental results prove the efficiency of the proposed methods and show that EEG could be used as a reliable indicator for depression recognition, which makes it possible for EEG-based portable system design and application in auxiliary depression recognition in the future.
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TRIM44 is indispensable for glioma cell proliferation and cell cycle progression through AKT/p21/p27 signaling pathway.Glioma is one of the lethal cancers which needs effective therapeutic target. TRIM44 has been found playing a carcinogenic role in human tumors such as breast cancer and ovarian cancer. However, the pathophysiological significance of TRIM44 in glioma is still unclear.
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Worry and metacognitions as predictors of the development of anxiety and paranoia.Recent studies have shown that worry and related negative metacognitions are characteristic in generalized anxiety and paranoia respectively. However, most of these studies did not take into account common co-occurrence of anxiety and paranoia, and longitudinal modelling of the role of worry and metacognitions on the development of anxiety and paranoia is rare. The current study aimed at examining the bidirectional longitudinal relationship between anxiety and paranoia, as well as the importance of worry and metacognitions in the development of these symptoms. Our validated sample consisted of 2291 participants recruited from universities, among whom 1746 participants (76.21%) completed online questionnaires at baseline and at one year, reporting levels of anxiety, paranoia, worry, and negative metacognitions. Structural equation modeling analyses, followed by path comparisons, revealed that anxiety and paranoia mutually reinforced each other over time. Negative metacognitions, rather than worry itself, were contributive to the development of both symptoms over time. Negative metacognitions showed bi-directional relationships with anxiety over the time period assessed and showed uni-directional relationships with paranoia. Clinical implications of our findings are discussed.
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Single-Cell RNA Sequencing Resolves Spatiotemporal Development of Pre-thymic Lymphoid Progenitors and Thymus Organogenesis in Human Embryos.Generation of the first T lymphocytes in the human embryo involves the emergence, migration, and thymus seeding of lymphoid progenitors together with concomitant thymus organogenesis, which is the initial step to establish the entire adaptive immune system. However, the cellular and molecular programs regulating this process remain unclear. We constructed a single-cell transcriptional landscape of human early T lymphopoiesis by using cells from multiple hemogenic and hematopoietic sites spanning embryonic and fetal stages. Among heterogenous early thymic progenitors, one subtype shared common features with a subset of lymphoid progenitors in fetal liver that are known as thymus-seeding progenitors. Unbiased bioinformatics analysis identified a distinct type of pre-thymic lymphoid progenitors in the aorta-gonad-mesonephros (AGM) region. In parallel, we investigated thymic epithelial cell development and potential cell-cell interactions during thymus organogenesis. Together, our data provide insights into human early T lymphopoiesis that prospectively direct T lymphocyte regeneration, which might lead to development of clinical applications.
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Cas9 Allosteric Inhibition by the Anti-CRISPR Protein AcrIIA6.In the arms race against bacteria, bacteriophages have evolved diverse anti-CRISPR proteins (Acrs) that block CRISPR-Cas immunity. Acrs play key roles in the molecular coevolution of bacteria with their predators, use a variety of mechanisms of action, and provide tools to regulate Cas-based genome manipulation. Here, we present structural and functional analyses of AcrIIA6, an Acr from virulent phages, exploring its unique anti-CRISPR action. Our cryo-EM structures and functional data of AcrIIA6 binding to Streptococcus thermophilus Cas9 (St1Cas9) show that AcrIIA6 acts as an allosteric inhibitor and induces St1Cas9 dimerization. AcrIIA6 reduces St1Cas9 binding affinity for DNA and prevents DNA binding within cells. The PAM and AcrIIA6 recognition sites are structurally close and allosterically linked. Mechanistically, AcrIIA6 affects the St1Cas9 conformational dynamics associated with PAM binding. Finally, we identify a natural St1Cas9 variant resistant to AcrIIA6 illustrating Acr-driven mutational escape and molecular diversification of Cas9 proteins.
Rabbit Anti-G Protein alp Rabbit Anti-APBB1 Fe65 pr Anti mouse adenomatous po Sheep Anti Mouse Protein Rabbit Anti-WNV Envelope Rabbit Anti-SRGN Chondroi Rabbit Anti-SEC14 like pr Proteins and Antibodies H Rabbit Anti-PRRSV M prote Rabbit Anti-14-3-3 family Rabbit Anti-HE4 Epididyma Rabbit Anti-TNIP2 ABIN2 T
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Initial and delayed thyroid-stimulating hormone elevation in extremely low-birth-weight infants.To determine the incidence, etiology, and outcomes of thyroid-stimulating hormone (TSH) elevation in extremely low-birth-weight infants (ELBWIs).
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Satellite testing of a gravitationally induced quantum decoherence model.Quantum mechanics and the general theory of relativity are two pillars of modern physics. However, a coherent unified framework of the two theories remains an open problem. Attempts to quantize general relativity have led to many rival models of quantum gravity, which, however, generally lack experimental foundations. We report a quantum optical experimental test of event formalism of quantum fields, a theory that attempts to present a coherent description of quantum fields in exotic spacetimes containing closed timelike curves and ordinary spacetime. We experimentally test a prediction of the theory with the quantum satellite that a pair of time-energy-entangled particles probabilistically decorrelate passing through different regions of the gravitational potential of Earth. Our measurement results are consistent with the standard quantum theory and hence do not support the prediction of event formalism.
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