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           Search results for: 6-Amino-1-isobutyl-3-methyl-5-nitroso-2,4-pyrimidinedione C9H14N4O3 CAS: 54052-67-4   

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#29036726   2017/10/16 Save this To Up

CONTRIBUTION OF DIFFERENT PARTICLES MEASURED WITH TRACK ETCHED DETECTORS ONBOARD ISS.

Cosmic radiation consists of primary high-energy galactic and solar particles. When passing through spacecraft walls and astronauts' bodies, the spectrum becomes even more complex due to generating of secondary particles through fragmentation and nuclear interactions. Total radiation exposure is contributed by both these components. With an advantage, space research uses track etched detectors from the group of passive detectors visualizing the tracks of particles, in this case by etching. The detectors can discriminate between various components of cosmic radiation. A method is introduced for the separation of the different types of particles according to their range using track etched detectors. The method is demonstrated using detectors placed in Russian segment of the International Space Station in 2009. It is shown that the primary high-energy heavy ions with long range contribute up to 56% of the absorbed dose and up to 50% to the dose equivalent.

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IpPore track etched membr IpPore track etched membr IpPore track etched membr IpPore track etched membr IpPore track etched membr IpPore track etched membr IpPore track etched membr IpPore track etched membr IpPore track etched membr IpPore track etched membr IpPore track etched membr IpPore track etched membr

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#29036693   2017/10/16 Save this To Up

ICG: a wiki-driven knowledgebase of internal control genes for RT-qPCR normalization.

Real-time quantitative PCR (RT-qPCR) has become a widely used method for accurate expression profiling of targeted mRNA and ncRNA. Selection of appropriate internal control genes for RT-qPCR normalization is an elementary prerequisite for reliable expression measurement. Here, we present ICG (http://icg.big.ac.cn), a wiki-driven knowledgebase for community curation of experimentally validated internal control genes as well as their associated experimental conditions. Unlike extant related databases that focus on qPCR primers in model organisms (mainly human and mouse), ICG features harnessing collective intelligence in community integration of internal control genes for a variety of species. Specifically, it integrates a comprehensive collection of more than 750 internal control genes for 73 animals, 115 plants, 12 fungi and 9 bacteria, and incorporates detailed information on recommended application scenarios corresponding to specific experimental conditions, which, collectively, are of great help for researchers to adopt appropriate internal control genes for their own experiments. Taken together, ICG serves as a publicly editable and open-content encyclopaedia of internal control genes and accordingly bears broad utility for reliable RT-qPCR normalization and gene expression characterization in both model and non-model organisms.

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EZH2 KMT6 Control Peptid GFP control peptide anti MOUSE ANTI BOVINE ROTAVIR Bone Morphogenetic Protei Growth Differentiation Fa HIV1-RT antibody, Monoclo HIV1-RT antibody, Monoclo HIV1-RT antibody, Monoclo Amplite™ Fluorimetric F FMK Negative Control ; Ap FMK Negative Control ; Ap QVD-OPh Negative Control;

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#29036690   2017/10/16 Save this To Up

Simultaneous Measurements of Nanoaerosols and Radioactive Aerosols Containing the Short-lived Radon Isotopes.

The activity size distribution of the Equilibrium-Equivalent Concentration (EER) of 222Rn is one of the most important parameters for the estimation of radiation dose by inhalation of radon decay products. A series of measurements of the EER activity size distribution were performed by the screen diffusion battery in Radon-Aerosol chamber (10 m3) at the National Institute for Nuclear, Chemical, and Biological Protection (SUJCHBO). These measurements were performed at different levels of radon concentration. For this study, the Graded Screen Array Diffusion Battery (GSA DB), developed by the SUJCHBO (based on Earl Knutson and Robert F Holub design), consists of 10 screens and backup filter used to collect all particles that penetrated the screens. The measuring range of this GSA DB allows measuring the radioactive nanoaerosols in the size range from 0.5 to 100 nm. The Earl Knutson algorithm was used for EER activity size distribution evaluation. The results of EER activity size distribution were subsequently compared with the aerosol particle size distribution measured by Scanning Mobility Particle Sizer Spectrometer (SMPS 3936 N, TSI Inc., MN, USA).

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BACTERIOLOGY BACTEROIDES Androgen Receptor (Phosph Androgen Receptor (Phosph Rabbit Anti-Human Androge Rabbit Anti-Human Androge Androgen Receptor (Ab 650 TCP-1 theta antibody Sour Recombinant Thermostable Recombinant Thermostable Recombinant Thermostable Recombinant Human PKC the Recombinant Human PKC the

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#29036676   2017/10/16 Save this To Up

Anti-CRISPRdb: a comprehensive online resource for anti-CRISPR proteins.

CRISPR-Cas is a tool that is widely used for gene editing. However, unexpected off-target effects may occur as a result of long-term nuclease activity. Anti-CRISPR proteins, which are powerful molecules that inhibit the CRISPR-Cas system, may have the potential to promote better utilization of the CRISPR-Cas system in gene editing, especially for gene therapy. Additionally, more in-depth research on these proteins would help researchers to better understand the co-evolution of bacteria and phages. Therefore, it is necessary to collect and integrate data on various types of anti-CRISPRs. Herein, data on these proteins were manually gathered through data screening of the literatures. Then, the first online resource, anti-CRISPRdb, was constructed for effectively organizing these proteins. It contains the available protein sequences, DNA sequences, coding regions, source organisms, taxonomy, virulence, protein interactors and their corresponding three-dimensional structures. Users can access our database at http://cefg.uestc.edu.cn/anti-CRISPRdb/ without registration. We believe that the anti-CRISPRdb can be used as a resource to facilitate research on anti-CRISPR proteins and in related fields.

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MOUSE ANTI BOVINE ROTAVIR Mouse Anti-RSV 33kDa & 19 MOUSE ANTI BORRELIA BURGD Anti Galectin(Gal 3) Huma Anti AGE 3 Monoclonal Ant RABBIT ANTI GSK3 BETA (pS Rat Anti-Mouse Forssman G Proteins and Antibodies H Proteins and Antibodies H Proteins and Antibodies H Proteins and Antibodies H Proteins and Antibodies H

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#29036650   2017/10/16 Save this To Up

Characteristic arrangement of nucleosomes is predictive of chromatin interactions at kilobase resolution.

High-throughput chromosome conformation capture (3C) technologies, such as Hi-C, have made it possible to survey 3D genome structure. However, obtaining 3D profiles at kilobase resolution at low cost remains a major challenge. Therefore, we herein present an algorithm for precise identification of chromatin interaction sites at kilobase resolution from MNase-seq data, termed chromatin interaction site detector (CISD), and a CISD-based chromatin loop predictor (CISD_loop) that predicts chromatin-chromatin interactions (CCIs) from low-resolution Hi-C data. We show that the predictions of CISD and CISD_loop overlap closely with chromatin interaction analysis by paired-end tag sequencing (ChIA-PET) anchors and loops, respectively. The validity of CISD/CISD_loop was further supported by a 3C assay at about 5 kb resolution. Finally, we demonstrate that only modest amounts of MNase-seq and Hi-C data are sufficient to achieve ultrahigh resolution CCI maps. Our results suggest that CCIs may result in characteristic nucleosomes arrangement patterns flanking the interaction sites, and our algorithms may facilitate precise and systematic investigations of CCIs on a larger scale than hitherto have been possible.

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#29036457   2017/10/16 Save this To Up

Feasibility evaluation of long-term use of beta-blockers and calcium antagonists in patients with Brugada syndrome.

Beta-blockers (BBs) and calcium antagonists (CAs) are reported to aggravate ST-segment elevation in some patients with Brugada syndrome (BrS). The feasibility of their long-term use in BrS still remains unknown. We investigated the safety of long-term use of BB and CA in BrS patients.

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#29036456   2017/10/16 Save this To Up

Role of free DNA ends and protospacer adjacent motifs for CRISPR DNA uptake in Pyrococcus furiosus.

To acquire CRISPR-Cas immunity against invasive mobile genetic elements, prokaryotes must first integrate fragments of foreign DNA into their genomic CRISPR arrays for use in future invader silencing. Here, we found that the hyperthermophilic archaeaon, Pyrococcus furiosus, actively incorporates DNA fragments (spacers) from both plasmid (foreign) and host genome (self) sequences into its seven CRISPR loci. The majority of new spacers were derived from DNA immediately downstream from a 5'-CCN-3' protospacer adjacent motif (PAM) that is critical for invader targeting. Interestingly, spacers were preferentially acquired from genome or plasmid regions corresponding to active transposons, CRISPR loci, ribosomal RNA genes, rolling circle origins of replication, and areas where plasmids recombined with the host chromosome. A common feature of the highly sampled spacers is that they arise from DNA regions expected to undergo DNA nicking and/or double-strand breaks. Taken together with recent results from bacterial systems, our findings indicate that free DNA termini and PAMs are conserved features important for CRISPR spacer uptake in diverse prokaryotes and CRISPR-Cas systems. Moreover, lethal self-targeting by CRISPR systems may contribute to host genome stability by eliminating cells undergoing active transposon mobility or chromosomal uptake of autonomously replicating foreign mobile genetic elements.

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#29036323   2017/10/16 Save this To Up

Structural basis for the specific recognition of 18S rRNA by APUM23.

PUF (Pumilio/fem-3 mRNA binding factor) proteins, a conserved family of RNA-binding proteins, recognize specific single-strand RNA targets in a specific modular way. Although plants have a greater number of PUF protein members than do animal and fungal systems, they have been the subject of fewer structural and functional investigations. The aim of this study was to elucidate the involvement of APUM23, a nucleolar PUF protein in the plant Arabidopsis, in pre-rRNA processing. APUM23 is distinct from classical PUF family proteins, which are located in the cytoplasm and bind to 3'UTRs of mRNA to modulate mRNA expression and localization. We found that the complete RNA target sequence of APUM23 comprises 11 nt in 18S rRNA at positions 1141-1151. The complex structure shows that APUM23 has 10 PUF repeats; it assembles into a C-shape, with an insertion located within the inner concave surface. We found several different RNA recognition features. A notable structural feature of APUM23 is an insertion in the third PUF repeat that participates in nucleotide recognition and maintains the correct conformation of the target RNA. Our findings elucidate the mechanism for APUM23's-specific recognition of 18S rRNA.

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MOUSE ANTI BOVINE ROTAVIR MOUSE ANTI BORRELIA BURGD NATIVE HUMAN PROLACTIN, P BYL-719 Mechanisms: PI3K- RABBIT ANTI GSK3 BETA (pS 10x ELISA WASH BUFFER, Pr 10X PHOSPHATE BUFFERED SA PERMANENT AQUEOUS MOUNTIN Multiple organ cancer tis Multiple organ tumor tiss MOUSE ANTI CANINE DISTEMP MOUSE ANTI HUMAN CD15, Pr

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#29035765   2017/10/16 Save this To Up

A force-based mechanistic model for describing activated sludge settling process.

Sludge settling as the last step in the biological wastewater treatment process substantially affects the system performance, and thus the design and control optimization of the sludge settling process has been frequently investigated with mathematical modeling tools. So far, these models are developed on the basis of the solid flux theory with numerous parameters and complicated boundary conditions, and their prediction results are often unsatisfactory. In this work, a new force-based mechanical model with five parameters was developed, in which five forces were adopted and Newton's law, rather than the flux theory, was used to describe the sludge settling process. In such a model, the phase interactions were taken into account. New functions of hydrodynamic drag, solids pressure and shear stress were developed. Model validation results demonstrate that both batch and continuous sludge settling processes could be accurately described by this model. The predictions of this model were more accurate than those of flux theory-based models, suggesting its advantages in understanding sludge settling behaviors. In addition, this mechanistic model needed to input 5 parameters and set 1 boundary condition only, and could be directly executed by commercial computational fluid dynamics software. Thus, this force-based model provides a more convenient and useful tool to improve the activated sludge settling design and operation optimization.

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Human Phospho-EGFR (Activ MarkerGeneTM Fluorescent MOUSE ANTI BOVINE ROTAVIR Bone Morphogenetic Protei anti SLAM anti CDw150 IgG Growth Differentiation Fa Amplite™ Fluorimetric F MOUSE ANTI BORRELIA BURGD succinate-CoA ligase, GDP ANTI ACTIVATED X FACTOR A formin-like 1 antibody So Recombinant Human p21 Act

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#29035497   2017/10/16 Save this To Up

Conformational Dynamics of DNA Binding and Cas3 Recruitment by the CRISPR RNA-guide Cascade Complex.

Bacteria and archaea rely on CRISPR (clustered regularly interspaced short palindromic repeats) RNA-guided adaptive immune systems for sequence specific elimination of foreign nucleic acids. In Escherichia coli, short CRISPR-derived RNAs (crRNAs) assemble with Cas (CRISPR-associated) proteins into a 405-kilodalton multi-subunit surveillance complex called Cascade (CRISPR-associated complex for antiviral defense). Cascade binds foreign DNA complementary to the crRNA guide and recruits Cas3, a trans-acting nuclease-helicase required for target degradation. Structural models of Cascade have captured static snapshots of the complex in distinct conformational states, but conformational dynamics of the 11-subunit surveillance complex have not been measured. Here we use hydrogen-deuterium exchange coupled to mass spectrometry (HDX-MS) to map conformational dynamics of Cascade onto the three-dimensional structure. New insights from structural dynamics are used to make functional predictions about the mechanisms of the R-loop coordination and Cas3 recruitment. We test these predictions in vivo and in vitro. Collectively, we show how mapping conformational dynamics onto static 3D-structures adds an additional dimension to the functional understanding of this biological machine.

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