Search results for: AV-951 (Tivozanib) Mechanisms: VEGFR inhibitor
#32692256 2020/07/21 To Up
Tivozanib, a highly potent and selective inhibitor of VEGF receptor tyrosine kinases, for the treatment of metastatic renal cell carcinoma.
The mutation- upregulation- transcription sequence is the principal pathway in the development of renal cell carcinoma. Tyrosine kinase inhibitors target the VEGF receptors to inhibit further growth of renal cell carcinoma tumors. Tivozanib, originally named AV-951 and KRN-951, is a novel, orally bioavailable VEGF tyrosine kinase inhibitor that is selective for VEGF receptors 1, 2 and 3. Further, only picomolar concentrations of tivozanib are required to target these VEGF receptors and prevent phosphorylation; this potency prevents the debilitating side effects that occur with treatments whose mechanisms of action involve broad-spectrum tyrosine kinase inhibition. This review summarizes the growing body of evidence supporting tivozanib's efficacy and safety in the treatment of advanced renal cell carcinoma.Allen Jacob, Jaret Shook, Thomas E Hutson
2384 related Products with: Tivozanib, a highly potent and selective inhibitor of VEGF receptor tyrosine kinases, for the treatment of metastatic renal cell carcinoma.
2 Pieces/Box2 Pieces/Box0.1ml (1mg/ml)100ugRelated Pathways
#24295377 2013/12/03 To Up
Tivozanib reverses multidrug resistance mediated by ABCB1 (P-glycoprotein) and ABCG2 (BCRP).
This study aimed to investigate the mechanism of reversal of multidrug resistance mediated by ABC transporters with tivozanib (AV-951 and KRN-951). Tivozanib is a potent inhibitor of VEGF-1, -2 and -3 receptors.Danwen Yang, Rishil J Kathawala, Eduardo E Chufan, Atish Patel, Suresh V Ambudkar, Zhe-Sheng Chen, Xiang Chen
1504 related Products with: Tivozanib reverses multidrug resistance mediated by ABCB1 (P-glycoprotein) and ABCG2 (BCRP).
100ug100ug Lyophilized 5 G5 ml100ul100 100ug Lyophilized 5 G100ug Lyophilized100ugRelated Pathways
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