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#10967041   2000/09/14 Save this To Up

Apoptosis in the endothelium of human corneas for transplantation.

To determine whether endothelial cell loss of human corneas stored in organ culture before transplantation is due to apoptosis.

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Apoptosis (Human) Antibod Apoptosis (Human) Antibod Rabbit Anti-Human Apoptos Anti AGO2 Human, Monoclon Anti AGO2 Human, Monoclon Bone Morphogenetic Protei Growth Differentiation Fa CELLKINES Natural Human I Human Interleukin-4 IL-4 Human Interleukin-6 IL-6 Human Interleukin-7 IL-7 Human Interleukin-2 IL-2

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#10830907   2000/06/14 Save this To Up

Structure and mutation analysis of the gene encoding DNA fragmentation factor 40 (caspase-activated nuclease), a candidate neuroblastoma tumour suppressor gene.

We have characterised the DFFB gene, encoding the active subunit of the apoptotic nuclease DNA fragmentation factor (DFF40). DFFB maps to 1p36, near the imprinted putative tumour suppressor gene TP73. The DFFA gene (encoding the inhibitory DFF45 subunit) also maps to 1p36.2-36.3, and we show by FISH that DFFB lies distal to DFFA. We have also mapped a processed DFFB pseudogene to chromosome 9. DFFB itself has seven coding exons spanning 10 kb. Exhaustive mutation screening of 41 neuroblastomas and other tumours in which a 1p36 tumour suppressor gene is implicated showed no tumour-specific mutations. A coding region polymorphism was used to demonstrate uniformly biallelic expression in human fetal DFFB transcripts. Since the putative neuroblastoma tumour suppressor gene in distal 1p36 is predicted to be maternally expressed, the lack of imprinting and absence of somatic mutations in DFFB indicate that it is probably not the neuroblastoma tumour suppressor gene.

2334 related Products with: Structure and mutation analysis of the gene encoding DNA fragmentation factor 40 (caspase-activated nuclease), a candidate neuroblastoma tumour suppressor gene.

DNA (cytosine 5) methyltr Anti PDX1 Polyclonal Anti Caspase-9 Blocking Peptid Caspase-10 Blocking Pepti Smad4 Blocking Peptide;Ap LRP-5 6 Blocking Peptide; Tom 40 Blocking Peptide;A anti-CAD (caspase-activat Rat monoclonal anti mouse Blue Feulgen DNA Ploidy Amplite™ Luciferase Rep Amplite™ Luciferase Rep

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