Only in Titles

           Search results for: Adenovirus antibody, Monoclonal Antibodies, Host Mouse, Isotype IgG1   

paperclip

#19124741   2009/01/06 Save this To Up

PD-1 blockade in rhesus macaques: impact on chronic infection and prophylactic vaccination.

Programmed Cell Death 1 (PD-1) plays a crucial role in immunomodulation. Binding of PD-1 to its ligand receptors down-regulates immune responses, and published reports suggest that this immune modulation is exploited in cases of tumor progression or chronic viral infection to evade immune surveillance. Thus, blockade of this signal could restore or enhance host immune functions. To test this hypothesis, we generated a panel of mAbs specific to human PD-1 that block PD ligand 1 and tested them for in vitro binding, blocking, and functional T cell responses, and evaluated a lead candidate in two in vivo rhesus macaque (Macaca mulatta) models. In the first therapeutic model, chronically SIV-infected macaques were treated with a single infusion of anti-PD-1 mAb; viral loads increased transiently before returning to, or falling below, pretreatment baselines. In the second prophylactic model, naive macaques were immunized with an SIV-gag adenovirus vector vaccine. Induced PD-1 blockade caused a statistically significant (p<0.05) increase in the peak percentage of T cells specific for the CM9 Gag epitope. These new results on PD-1 blockade in nonhuman primates point to a broader role for PD-1 immunomodulation and to potential applications in humans.

2331 related Products with: PD-1 blockade in rhesus macaques: impact on chronic infection and prophylactic vaccination.

Rabbit Anti-FGF3 Oncogene Liver cancer tissue array Liver tissue cancer tissu Bcl-2 Oncoprotein; Clone Bcl-2 Oncoprotein; Clone Bcl-2 Oncoprotein; Clone BCIP INT Solution Sterile filtered goat se Sterile filtered rat ser Anti AGO2 Human, Monoclon Anti AGO2 Mouse, Monoclon anti HCMV IE pp65 IgG1 (m

Related Pathways