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Search results for: Caspase 1 Inhibitor Z YVAD FMK

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#38054647   2023/12/06 To Up

Lycopene Alleviates Chronic Stress-Induced Hippocampal Microglial Pyroptosis by Inhibiting the Cathepsin B/NLRP3 Signaling Pathway.

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Qiuxiang Zhu, Zhicheng Gao, Jinghui Peng, Chang Liu, Xiaoyue Wang, Shoujun Li, Haiyang Zhang

1870 related Products with: Lycopene Alleviates Chronic Stress-Induced Hippocampal Microglial Pyroptosis by Inhibiting the Cathepsin B/NLRP3 Signaling Pathway.

2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box1.5 x 10^6 cells2 Pieces/Box2 Pieces/Box1 mg2 Pieces/BoxInhibitors

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#38001089   2023/11/25 To Up

Loss of p53 function promotes DNA damage-induced formation of nuclear actin filaments.

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Takeru Torii, Wataru Sugimoto, Katsuhiko Itoh, Natsuki Kinoshita, Masaya Gessho, Toshiyuki Goto, Ikuno Uehara, Wataru Nakajima, Yemima Budirahardja, Daisuke Miyoshi, Takahito Nishikata, Nobuyuki Tanaka, Hiroaki Hirata, Keiko Kawauchi

2094 related Products with: Loss of p53 function promotes DNA damage-induced formation of nuclear actin filaments.

5 G96 assays 6 ml Ready-to-use 50 200.00 ug100ug25 assays100 100ug Lyophilized

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#37593179   2023/08/01 To Up

Inhibition of GSDMD activation by Z-LLSD-FMK or Z-YVAD-FMK reduces vascular inflammation and atherosclerotic lesion development in ApoE mice.

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Bao-Li Zhang, Peng Yu, En-Yong Su, Chun-Yu Zhang, Shi-Yao Xie, Xue Yang, Yun-Zeng Zou, Ming Liu, Hong Jiang

2180 related Products with: Inhibition of GSDMD activation by Z-LLSD-FMK or Z-YVAD-FMK reduces vascular inflammation and atherosclerotic lesion development in ApoE mice.

5 mg20 ul (10 mM)1 mg96 assays 4 Sample Kit1 mg

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#35439536   2022/04/16 To Up

Involvement of NLRP3/Caspase-1/GSDMD-Dependent pyroptosis in BPA-Induced apoptosis of human neuroblastoma cells.

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Congcong Wang, Lei Wang, Chengmeng Huang, Yungang Liu, Jian Liu, Hongxuan Kuang, Qihua Pang, Hongyu Han, Ruifang Fan

1157 related Products with: Involvement of NLRP3/Caspase-1/GSDMD-Dependent pyroptosis in BPA-Induced apoptosis of human neuroblastoma cells.

4 Arrays/Slide1.00 flask5ug100 10 ug1.00 flask50 ul 100ul4 Membranes/Box1 mg100 ul1.00 flask

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#35437791   2022/04/28 To Up

Reactive oxygen species-mediated activation of NLRP3 inflammasome associated with pyroptosis in Het-1A cells induced by the co-exposure of nitrosamines.

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Qiwei Liu, Chao Zhao, Jingjing Zhou, Hu Zhang, Ying Zhang, Shizhi Wang, Yuepu Pu, Lihong Yin

1678 related Products with: Reactive oxygen species-mediated activation of NLRP3 inflammasome associated with pyroptosis in Het-1A cells induced by the co-exposure of nitrosamines.

100ul100ug100ug96T 100ul2 mg96 assays96T100 ug

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#34901142   2021/11/26 To Up

Caspase-1 Inhibitor Reduces Pyroptosis Induced by Brain Death in Kidney.

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Weifeng Liu, Dongjing Yang, Jihua Shi, Peihao Wen, Jiakai Zhang, Zhihui Wang, Bowen Hu, Xiaoyi Shi, Shengli Cao, Wenzhi Guo, Shuijun Zhang

2987 related Products with: Caspase-1 Inhibitor Reduces Pyroptosis Induced by Brain Death in Kidney.

20 ul (10 mM)100ug Lyophilized20 ul (10 mM)20 µl100μg100 assays100 µl (2 mM)20 100 10mg100ug Lyophilized100 µl (2 mM)

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#34797502   2021/11/19 To Up

NLRP3 Inflammasome Activation Enhances ADK Expression to Accelerate Epilepsy in Mice.

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Haiju Zhang, Shiqian Yu, Liping Xia, Xia Peng, Shun Wang, Baozhen Yao

1542 related Products with: NLRP3 Inflammasome Activation Enhances ADK Expression to Accelerate Epilepsy in Mice.

2 mg10300 units100 500 gm.100ug96 wells (1 kit)25 100

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#34356509   2021/07/12 To Up

MCPIP1 Enhances TNF-α-Mediated Apoptosis through Downregulation of the NF-κB/cFLIP Axis.

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Fat-Moon Suk, Chi-Ching Chang, Pei-Chi Sun, Wei-Ting Ke, Chia-Chen Chung, Kun-Lin Lee, Tze-Sian Chan, Yu-Chih Liang

2039 related Products with: MCPIP1 Enhances TNF-α-Mediated Apoptosis through Downregulation of the NF-κB/cFLIP Axis.

100 100ug Lyophilized 100ul100 ug15 ready-to-use apoptosis 1 kit200 units400 assays4 Arrays/Slide100ug Lyophilized

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#33650689   2021/03/02 To Up

Hyperglycemia accelerates inflammaging in the gingival epithelium through inflammasomes activation.

Diabetes accelerates inflammaging in various tissue with an increase in senescent cell burden and senescence-associated secretory phenotype (SASP) secretion, which is a significant cause of tissue dysfunction and contributes to the diabetic complications. Recently, inflammasomes are thought to contribute to inflammaging. Here, utilizing diabetic models in vivo and in vitro, we investigated the potential association between hyperglycemia-induced inflammaging and gingival tissue dysfunction and the mechanism underlying inflammasome-associated inflammaging.
Peng Zhang, Boyao Lu, Rui Zhu, Dawei Yang, Weiqing Liu, Qian Wang, Ning Ji, Qianming Chen, Yi Ding, Xing Liang, Qi Wang

1417 related Products with: Hyperglycemia accelerates inflammaging in the gingival epithelium through inflammasomes activation.

2 mg100μg100ug125 Bags/Unit100ug

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#33383234   2020/12/16 To Up

Reduced intracellular antioxidant capacity in platelets contributes to primary immune thrombocytopenia via ROS-NLRP3-caspase-1 pathway.

Primary immune thrombocytopenia (ITP) is a common acquired autoimmune hemorrhagic disease characterized by a low platelet count and increased risk of bleeding. However, some patients do not respond well to current therapeutic approaches. Further studies on pathogenesis and pathophysiology of ITP are needed to discover new therapeutic targets. We explored the role of enhanced intracellular oxidative stress and NLRP3 inflammasome activation of platelets in ITP. The expression of NLRP3 inflammasome was assessed in platelets from active ITP patients and healthy donors. Both the mRNA and protein expression level of platelet NLRP3 inflammasome was upregulated in ITP patients compared with healthy donors. Besides, the elevated caspase-1 activity and increased co-localization of NLRP3 and its adaptor molecule ASC indicated activation of NLRP3 inflammasome in ITP platelets. Significantly decreased intracellular antioxidant capacity was observed in ITP platelets. HO supplementation elevated the expression of NLRP3 inflammasome and increased IL-1β secretion in ITP platelets. Preincubating ITP platelets with NAC down-regulated the expression of NLRP3 inflammasome. Pretreating ITP platelets with NLRP3 inhibitor MCC950 or caspase-1 inhibitor Z-YVAD-FMK significantly reduced the proportion of pyroptotic cells in HO-treated ITP platelets and suppressed IL-1β secretion in supernatants. Hence, platelet NLRP3 inflammasome activation resulted from reduced intracellular antioxidant capacity plays a critical role in ITP and might have potential diagnostic or therapeutic implications.
Shuang Wang, Yang Liu, Guosheng Li, Qi Feng, Ming Hou, Jun Peng

1883 related Products with: Reduced intracellular antioxidant capacity in platelets contributes to primary immune thrombocytopenia via ROS-NLRP3-caspase-1 pathway.

100 assays100ug100ug100 assays1 kit961 kit100ug/vial100ug100ug

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