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#16337965   2005/12/09 To Up

Enhanced sensitivity to chemotherapy in esophageal cancer through inhibition of NF-kappaB.

Apoptosis induced by chemotherapeutic drugs is blocked by activation of nuclear factor-kappaB (NF-kappaB) in some cancer cell lines. Therefore, inhibition of NF-kappaB by adenoviral delivery of an IkappaBalpha super-repressor (Ad.IkappaBalpha-SR) should make esophageal cancer cells more sensitive to 5- fluorouracil (5-FU) and taxotere chemotherapy.
Jing Li, Douglas J Minnich, Ernest R Camp, Adam Brank, Sally L D Mackay, Steven N Hochwald

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