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#28440480   2017/04/25 Save this To Up

Palmitate impairs angiogenesis via suppression of cathepsin activity.

Angiogenesis requires the interaction of multiple variable factors to promote endothelial cell adhesion, migration and survival. Palmitate, a free fatty acid, exhibits an anti‑angiogenic effect via interference with endothelial cell function, whereas cysteine proteases are important in protein turnover and are termed positive modulators of neovascularization. However, the association between these two factors regarding the regulation of human endothelial cell function remains to be elucidated. By using cell counting kit‑8, the Transwell method and an annexin V‑fluorescein isothiocyanate/propidium iodide apoptosis detection kit, the present study reported that high levels of palmitate result in a significant decrease in endothelial cell proliferation and invasion, and induced cell apoptosis; cathepsin L and S inhibitors may suppress palmitate‑induced apoptosis. Conversely, the results of the cathepsin L and S activity assay and reverse-transcription-quantitative polymerase chain reaction indicated that palmitate inhibited cathepsin‑induced endothelial cell invasion, partially via suppressing the expression and activity of cathepsin L and S. The findings of the present study suggested that the potent anti‑angiogenic properties of palmitate may be mediated by cysteine proteases.

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Cathepsin B Activity Assa Cathepsin K Activity Assa Cathepsin L Activity Assa Cathepsin D Activity Assa Cathepsin S Activity Assa Cathepsin H Activity Assa Rapid Microplate Assay K Cathepsin D Cathepsin D Cathepsin D; Clone C5 Cathepsin D; Clone C5 Cathepsin D

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#27901001   2016/11/30 Save this To Up

Ultraviolet A Enhances Cathepsin L Expression and Activity via JNK Pathway in Human Dermal Fibroblasts.

Cathepsin L (CatL) is a cysteine protease with strong matrix degradation activity that contributes to photoaging. Mannose phosphate-independent sorting pathways mediate ultraviolet A (UVA)-induced alternate trafficking of CatL. Little is known about signaling pathways involved in the regulation of UVA-induced CatL expression and activity. This study aims to investigate whether a single UVA irradiation affects CatL expression and activity and whether mitogen-activated protein kinase (MAPK)/activator protein-1 (AP-1) pathway is involved in the regulation of UVA-induced CatL expression and activity in human dermal fibroblasts (HDFs).

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Cathepsin B&L Inhibitor Z Goat Anti-Human LTF, (int Goat Anti-Human LRP4 LRP1 Goat Anti-Human LIP1 LKB1 Goat Anti-Human LIMP2 SCA Goat Anti-Human LASS1, (i Goat Anti-Human Laforin ( Goat Anti-Human Endotheli Mouse Anti-Human Interleu anti H inh human blood an RANK Ligand Soluble, Huma RANK Ligand Soluble, Huma

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