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#25134433   2014/08/18 To Up

Variable NF-κB pathway responses in colon cancer cells treated with chemotherapeutic drugs.

The nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway is activated in cells exposed to various stimuli, including those originating on the cell surface or in the nucleus. Activated NF-κB signaling is thought to enhance cell survival in response to these stimuli, which include chemotherapy and radiation. In the present effort, we determined which anticancer drugs preferentially activate NF-κB in colon cancer cells.
Temesgen Samuel, Khalda Fadlalla, Dominique N Gales, Balananda D K Putcha, Upender Manne

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