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Search results for: Dog Fibrinogen ELISA Kit

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#33243453   2020/11/20 To Up

Presence of nucleosomes in plasma and increased thrombin generation in dogs with acute and chronic gastroenteropathies.

Neutrophil extracellular traps (NETs) which contain nucleosomes protect the host by eliminating extracellular pathogens. However, any inflammatory stimuli can activate NETs and eventually lead to an immune overreaction leading to autoimmune diseases and thrombosis. Acute/chronic gastroenteropathies(aGE/cGE) are prevalent in dogs, and are associated with a strong inflammatory component. The aim of this study was to investigate if dogs with aGE and cGE have increased concentrations of nucleosomes indicative of NETs formation, and whether increased concentrations of nucleosomes are associated with hypercoagulability determined by increased thrombin generation. Twenty-six dogs were enrolled. The dogs were healthy (n = 11), or presented with aGE(n = 7) or cGE(n = 8). Minimum database including CRP, APTT, PT and fibrinogen, was obtained from all dogs. Citrated plasma was batched and used for subsequent analyses. Nucleosome concentration was analysed using a Cell-Death Detection ELISA-kit and thrombin generation by a calibrated automated thrombogram assay. No statistical differences in nucleosome concentrations were present between the groups. Although a numerically increased concentration of nucleosomes where seen in dogs with aGE(median;range) (0.019 AU;0.003-0.088) and cGE(0.023 AU;0.011-0.256) compared to controls(0.007 AU;0.003-0.042). One dog with GI-lymphoma demonstrated a markedly increased concentration of nucleosomes (0.256 AU). Dogs with aGE showed increased thrombin generation by increased peak (p = 0.03) and endogenous thrombin potential (p = 0.03); and increased CRP (p = 0.001), fibrinogen (p = 0.0002) and prolonged APTT (p = 0.03) compared to controls. This proof of concept study demonstrates that dogs with aGE and cGE have presence of nucleosomes with marked increase in one dog with GI-lymphoma. Nucleosomes might be linked to haemostatic alterations in dogs with inflammatory and neoplastic diseases.
A K H Krogh, J G Lyngby, C R Bjørnvad, L N Nielsen

1979 related Products with: Presence of nucleosomes in plasma and increased thrombin generation in dogs with acute and chronic gastroenteropathies.

0.05 mg1 mg96 tests96T96 tests

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#23875771   2013/07/22 To Up

Markers of coagulation activation, endothelial stimulation, and inflammation in dogs with babesiosis.

Babesia infections in dogs can result in a wide range of clinical and laboratory presentations, including coagulopathy. Expression of intercellular adhesion molecule-1 (ICAM-1) and von Willebrand factor (vWF) in dogs with babesiosis is unknown.
R Barić Rafaj, J Kuleš, J Selanec, N Vrkić, V Zovko, M Zupančič, A Trampuš Bakija, V Matijatko, M Crnogaj, V Mrljak

2188 related Products with: Markers of coagulation activation, endothelial stimulation, and inflammation in dogs with babesiosis.

4 Sample Kit4 Membranes/Box32-50 Sample Kit1.00 flask16 Arrays/Slide4 Sample Kit2 mg100μg8 Sample Kit25 Bags/Unit4 Membranes/Box

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#14672437   // To Up

Evaluation of a canine D-dimer point-of-care test kit for use in samples obtained from dogs with disseminated intravascular coagulation, thromboembolic disease, and hemorrhage.

To evaluate a canine D-dimer point-of-care (cD-d POC) test kit for use in healthy dogs and dogs with disseminated intravascular coagulation (DIC), thromboembolic disease (TED), and hemorrhage.
Alison Griffin, Mary Beth Callan, Frances S Shofer, Urs Giger

1996 related Products with: Evaluation of a canine D-dimer point-of-care test kit for use in samples obtained from dogs with disseminated intravascular coagulation, thromboembolic disease, and hemorrhage.

12tests96 tests96 tests96 tests96 tests120tests16 Arrays/Slide50 ul 50 UG

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