Only in Titles

           Search results for: ELISA Kit for Human Galectin 9(GAL9)   

paperclip

#30396167   // Save this To Up

Plasma Galectin-9 Concentrations in Normal and Diseased Condition.

Galectin-9 is a soluble immune modulator with versatile functions, including a role as an immune checkpoint molecule. Therefore, the amount of galectin-9 in the blood may reflect an individual's immunological balance. Many studies have conducted galectin-9 measurements; however, the reported galectin-9 concentration in the blood varies greatly, even within healthy controls. This study investigates the variation between the reported and actual concentrations of galectin-9.

1450 related Products with: Plasma Galectin-9 Concentrations in Normal and Diseased Condition.

Lipoproteins, Human Plasm BMS-911543 Mechanisms: JA SCH-900776 Mechanisms: CH Multiple organ normal and Multiple organ normal and Multiple organs tumor and Multiple organ normal and Multiple organ normal and Stomach adenocarcinoma wi Liver carcinoma and norma Liver carcinoma and norma Liver carcinoma and norma

Related Pathways

  •  
  • No related Items
paperclip

#29807358   // Save this To Up

Activation of TGF-β1/α-SMA/Col I Profibrotic Pathway in Fibroblasts by Galectin-3 Contributes to Atrial Fibrosis in Experimental Models and Patients.

This study aimed to evaluate whether galectin-3 (Gal-3) contributes actively to atrial fibrosis both in patients and experimental atrial fibrillation (AF) models.

1056 related Products with: Activation of TGF-β1/α-SMA/Col I Profibrotic Pathway in Fibroblasts by Galectin-3 Contributes to Atrial Fibrosis in Experimental Models and Patients.

Goat Anti-Human COL4A3BP Macrophage Colony Stimula Macrophage Colony Stimula Stat3 Activation Inhibito EtBr Destaining Bag Kit A Recombinant Human Interfe Native Influenza HA (A To Native Influenza HA (A To Native Influenza HA (A To Cell Meter™ Fluorimetri Cell Meter™ Fluorimetri Recombinant Human Inhibin

Related Pathways

  •  
  • No related Items
paperclip

#28545132   // Save this To Up

Proteomics investigation of OSCC-specific salivary biomarkers in a Hungarian population highlights the importance of identification of population-tailored biomarkers.

Oral squamous cell carcinoma (OSCC) accounting for about 90% of malignant oral lesions is the 6th most common malignancy worldwide. Diagnostic delay may contribute to dismal survival rate therefore, there is a need for developing specific and sensitive biomarkers to improve early detection. Hungarian population occupies the top places of statistics regarding OSCC incidence and mortality figures therefore, we aimed at finding potential salivary protein biomarkers suitable for the Hungarian population. In this study we investigated 14 proteins which were previously reported as significantly elevated in saliva of patients with OSCC. In case of IL-1α, IL-1β, IL-6, IL-8, TNF-α and VEGF a Luminex-based multiplex kit was utilized and the salivary concentrations were determined. In case of catalase, profilin-1, S100A9, CD59, galectin-3-bindig protein, CD44, thioredoxin and keratin-19, SRM-based targeted proteomic method was developed and the relative amount of the proteins was determined in the saliva of patients with OSCC and controls. After several rounds of optimization and using stable isotope-containing peptides, we developed an SRM-based method for rapid salivary protein detection. The validation of the selected potential biomarkers by ELISA revealed salivary protein S100A9 and IL-6 as useful protein biomarkers for OSCC detection improving the diagnostic accuracy for OSCC in the Hungarian population.A noninvasive diagnostic method to detect biomarkers useful for the early diagnosis of OSCC was developed. This can be an attractive strategy in screening saliva samples collected in a nation-wide multi-centric study in order to decrease morbidity, mortality, to enhance survival rate and to improve quality of life. The heterogeneity of protein biomarkers found in different ethnic groups presented in the literature highlights the importance of identification of population-tailored protein biomarkers.

1200 related Products with: Proteomics investigation of OSCC-specific salivary biomarkers in a Hungarian population highlights the importance of identification of population-tailored biomarkers.

Multiple organ tumor tiss BYL-719 Mechanisms: PI3K- IPI-145 (INK-1197) Mechan Apoptosis antibody array Cell cycle antibody array Cytokine antibody array i Signal transduction antib AKT Phospho-Specific Arra AKT PKB Signaling Phospho AMPK Signaling Phospho-Sp Apoptosis Phospho-Specifi Cancer Apoptosis Phospho-

Related Pathways

paperclip

#28339804   // Save this To Up

Intra-cardiac and peripheral levels of biochemical markers of fibrosis in patients undergoing catheter ablation for atrial fibrillation.

Measurement of circulating biomarkers of fibrosis may have a role in selecting patients and treatment strategy for catheter ablation. Pro-collagen type III N-terminal pro-peptide (PIIINP), C-telopeptide of type I collagen (ICTP), fibroblast growth factor 23 (FGF-23), and galectin 3 (gal-3) have all been suggested as possible biomarkers for this indication, but studies assessing whether peripheral levels reflect intra-cardiac levels are scarce.

2421 related Products with: Intra-cardiac and peripheral levels of biochemical markers of fibrosis in patients undergoing catheter ablation for atrial fibrillation.

Troponin I test card, ser Myoglobin test card, seru (7’-Benzyloxy-indolymet Cardiac markers: Troponi Breast cancer tissue arra Breast disease spectrum t Breast invasive ductal ca Multiple lung carcinoma ( Indole 7 carboxaldehyde ( Indole 3 carboxaldehyde ( Indole 6 carboxaldehyde ( Ofloxacin CAS Number [824

Related Pathways

paperclip

#27615366   // Save this To Up

Establishment of mouse Mac-2 binding protein enzyme-linked immunosorbent assay and its application for mouse chronic liver disease models.

We identified Mac-2 (galectin-3) binding protein (Mac-2bp) as a novel diagnostic and liver fibrosis predicting biomarker for nonalcoholic steatohepatitis in humans. In mouse models, there are no serum biomarkers predicting liver disease severity. In this study, we developed a mouse Mac-2bp enzyme-linked immunosorbent assay (ELISA) system and determined its efficacy for predicting the severity of liver disease in mouse models, especially in non-alcoholic fatty liver disease (NAFLD) models.

2612 related Products with: Establishment of mouse Mac-2 binding protein enzyme-linked immunosorbent assay and its application for mouse chronic liver disease models.

Rabbit Anti-HE4 Epididyma Rabbit Anti-HE4 Epididyma Rabbit Anti-APIP Apaf1 In Rabbit Anti-APIP Apaf1 In Rabbit Anti-Cell death in Rabbit Anti-Cell death in anti-Vitamin D binding pr Mouse Anti-RSV Fusion Pro MOUSE ANTI BOVINE ROTAVIR Mouse Anti-Human Retinol MBP(myelin basic protein) Transmembrane protein 147

Related Pathways

paperclip

#27394439   // Save this To Up

Expression of human T cell immunoglobulin domain and mucin-3 (TIM-3) and TIM-3 ligands in peripheral blood from patients with systemic lupus erythematosus.

Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disease. The T cell immunoglobulin and mucin domain (TIM) family is associated with autoimmune diseases, but its level of expression in the immune cells of patients with SLE is still uncertain. The aim of this study was to examine whether TIM-3 and Galectin-9 (Gal-9) contribute to the pathogenesis of SLE. In total, 30 patients with SLE and 30 healthy controls were recruited, and their levels of TIM-3 expression in peripheral blood mononuclear cells (PBMCs) were examined via flow cytometry. Meanwhile, the levels of Gal-9 expression in serum and in PBMCs were measured via an enzyme-linked immunosorbent assay (ELISA) kit and immunofluorescence staining, respectively. The relation between the level of TIM-3 or Gal-9 expression and the SLE disease activity index (SLEDAI) was also studied. Finally, the function of the TIM-3 and Gal-9 pathway in the pathogenesis of SLE was explored. Our results showed that the levels of expression of TIM-3 and Gal-9 on CD4(+) T cells, CD8(+) T cells, CD56(+) T cells and in serum in patients with SLE were significantly higher than those of healthy controls. We found that the level of Gal-9 expression was significantly higher in both serum and PMBCs of patients with SLE than in healthy controls. The up-regulation of TIM-3 and Gal-9 expression in patients with SLE was closely related to the SLEDAI scores. In addition, Gal-9 blocking antibody significantly inhibited CD3-stimulated PBMC proliferation and Th1-derived cytokines (IL-2, IFN-γ, and TNF-α), Th2-derived cytokines (IL-4, IL-10), a Th17-derived cytokine (IL-17A), and release of a pro-inflammatory factor (IL-6) in patients with SLE. The results suggest that increased expression of TIM-3 and Gal-9 may be a biomarker for SLE diagnosis and that the TIM-3 pathway may be a target for SLE treatment.

1252 related Products with: Expression of human T cell immunoglobulin domain and mucin-3 (TIM-3) and TIM-3 ligands in peripheral blood from patients with systemic lupus erythematosus.

Turkey Red Blood Cells 5% CELLKINES Natural Human I AZD-3514 Mechanisms: Andr ∆1-Androstene-3α,17β- Rabbit Anti-ATP carrier p Rabbit Anti-ATP carrier p Rabbit Anti-EDA2R TNFRSF2 Rabbit Anti-EDA2R TNFRSF2 Rabbit Anti-TIP30 Polyclo Rabbit Anti-TIP30 Polyclo Goat Anti-Human Androgen Rabbit Anti-Human TRRAP (

Related Pathways

paperclip

#22460234   // Save this To Up

Placental protein 13 as an early predictor in Egyptian patients with preeclampsia, correlation to risk, and association with outcome.

Placental protein 13 (PP13) is a protein expressed only in the placenta. It is involved in gluing the placenta to the uterus and remodeling the maternal arteries to expand them. Women who subsequently develop preterm preeclampsia have low first trimester maternal serum.

2850 related Products with: Placental protein 13 as an early predictor in Egyptian patients with preeclampsia, correlation to risk, and association with outcome.

Rabbit Anti-Human Toll In Toxoplasma gondii GRA8, r FIV Core Ag, recombinant HCV NS3 1359 1456aa antig HIV 1 intergase antigen. TOM1-like protein 2 antib Native Influenza HA (A To Native Influenza HA (A To Native Influenza HA (A To Cell Meter™ Fluorimetri Cell Meter™ Fluorimetri MID1 interacting G12-like

Related Pathways

paperclip

#22230397   // Save this To Up

Galectin-3 plasma levels and coronary artery disease: a new possible biomarker of acute coronary syndrome.

Inflammation plays a key role in atherosclerosis. Galectin-3 is a macrophage- and endothelium-derived mediator actively involved in the regulation of many aspects of inflammatory cell behaviour. The aim of this study is to quantify plasma Galectin-3 in patients with coronary artery disease (CAD) and different clinical manifestation at the moment of observation in order to verify whether Galectin-3 could be a useful biomarker of atherosclerotic state. We enrolled 125 patients affected by CAD, angiographically documented (70 stable, 55 unstable). They underwent accurate examinations and anamnestic data was collected. The most important traditional risk factors, such as age, hypertension, and body mass index, were reported. Plasma Galectin-3 was quantified using an ELISA kit. Unstable patients (n = 55) had a higher plasma Galectin-3 levels in respect to the stable subjects (27.75 ng/mL (19.27-39.09) vs 6.48 ng/ml (4.88-8.83), p<0.001. A trend in correlation between plasma Galectin-3 levels and number of vessels compromised seems to be present: CAD patients with three-vessel disease had higher levels of Galectin-3 than patients with one-or two-vessel disease (17.39 ng/ml (10.75-29.82) vs 9.18 ng/ml (5.56-23.22), p= 0.058. The significantly higher plasma Galectin-3 levels in patients with unstable angina in respect to the stable angina confirm the involvement of Galectin-3 in promoting macrophage activation and monocyte attraction. Despite the distribution of CAD in patients with acute and chronic coronary disease being similar, we may hypothesize that Galectin-3 could be a useful biomarker of atherosclerotic plaque and in particular of its destabilization.

2652 related Products with: Galectin-3 plasma levels and coronary artery disease: a new possible biomarker of acute coronary syndrome.

Human Coronary Artery End GFP Expressing Human Coro AZD-3514 Mechanisms: Andr ∆1-Androstene-3α,17β- Bovine Androstenedione,AS Mouse Anti-Newcastle Dise Disease State Samples: Si Mouse Anti-Newcastle Dise Confocal Dish,PS,clear, 3 Active Human Caspase 3100 Androgen Receptor (Phosph Androgen Receptor (Phosph

Related Pathways

paperclip

#18395901   // Save this To Up

Pancreatic stellate cells promote proliferation and invasiveness of human pancreatic cancer cells via galectin-3.

To investigate the role of pancreatic stellate cells (PSCs) and galectin-3 (GAL-3) in the proliferation and infiltration of pancreatic cancer cell line SW1990.

2571 related Products with: Pancreatic stellate cells promote proliferation and invasiveness of human pancreatic cancer cells via galectin-3.

Human Pancreatic Microvas Epidermal Growth Factor ( Epidermal Growth Factor ( Glucagon ELISA KIT, Rat G anti CD7 All T cells Reco anti Transferrin receptor Anti C Reactive Protein A Macrophage Colony Stimula Macrophage Colony Stimula glial cells missing homol Pancreatic Lipase antibod Pancreatic Amylase antibo

Related Pathways

paperclip

#18319555   // Save this To Up

Serum level of galectin-3 in human bladder cancer.

We examine serum level of galectin-3 in patients with bladder cancer. We used serum samples of 67 patients with urological diseases and classified these patients into bladder cancer group (n=43) and control group (n=24). Galectin-3 concentration was measured by ELISA (Human Galectin-3 Assay Kit, IBL). And we selected the patient with high serum galectin-3 concentration (Urothelial Carcinoma, G3, pT3a pN0M0), we performed immunohistochemical staining with the VECTASTAIN ABC (Avidin Biotinylated enzyme Complex) system. Median value of serum galectin-3 concentration was 1068 pg/ml (range 551-2028) in the cancer group vs 584 pg/ml (range 259-1262) in controls. Serum galectin-3 concentration of the bladder cancer patients was statistically higher than that of controls (p<0.0005). There was no apparent correlation in serum galectin-3 concentration with the clinico-pathological features such as stage and grade. Higher expression of galectin-3 was observed in bladder cancer tissue than in normal bladder tissue. We suggest the measurement of serum galectin-3 is useful for diagnosis of bladder cancer.

1454 related Products with: Serum level of galectin-3 in human bladder cancer.

Bladder cancer tissue arr Bladder cancer tissue arr Bladder cancer and normal Bladder cancer tissue arr Mid advanced stage bladde Bladder cancer tissue arr Bladder cancer tissue arr Bladder cancer tissue arr Mid advanced stage bladde Bladder cancer tissue arr Human breast invasive duc Human interleukin 2(IL-2)

Related Pathways