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Surveillance of the equine infectious anemia virus in Eastern and Central Saudi Arabia during 2014-2016.

Equine infectious anemia virus (EIAV) is one of the most important threats to the equine industry globally. This is due to the poor performance of the affected horses, which requires euthanization of the infected animals upon the infection confirmation. Infected animals remain carriers throughout their life. EIAV infection has been reported in many parts of the world, including North America, Europe, Asia, and Africa. However, the EIAV status is never assessed in horses in the Gulf area, especially in the Kingdom of Saudi Arabia (KSA).

1726 related Products with: Surveillance of the equine infectious anemia virus in Eastern and Central Saudi Arabia during 2014-2016.

FIV Core Ag, recombinant Anti-Infectious Pancreati Anti-Infectious Pancreati Anti-Infectious Pancreati Anti-Infectious Pancreati H. Pylori antigen test ca Native Parainfluenza Viru Mouse Anti-Influenza A Vi FDA Standard Frozen Tissu Mouse Anti-Influenza B Vi Interleukins Recombinant Native Influenza A Virus

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Neutrophil Gelatinase-Associated Lipocalin2 Exaggerates Cardiomyocyte Hypoxia Injury by Inhibiting Integrin β3 Signaling.

BACKGROUND The neutrophil inflammatory protein, lipocalin-2 (NGAL), is elevated in certain forms of cardiac hypertrophy and acute heart failure. However, the specific role of NGAL in cardiac hypoxia injury is unclear. This study aimed to elucidate the functional role of NGAL in cardiomyocyte hypoxia injury. MATERIAL AND METHODS Neonatal rat cardiomyocytes were transfected with adenovirus [(Ad-NGAL] to overexpress human-NGAL and then were exposed to hypoxia for 24 h to establish a hypoxia model. Cell inflammation was detected by RT-PCT and ELISA assay. Cell apoptosis was detected by TUNEL assay. Oxidative stress was also detected by commercial kits. RESULTS An increased inflammatory response, apoptosis, and augmented oxidative stress were observed after exposure to hypoxia, while NGAL overexpression in cells increased the expression and release of inflammatory cytokines. NGAL overexpression also increased the number of apoptotic cells and the imbalance of Bax/Bcl-2 protein expression. Moreover, NGAL overexpression increased the levels of reactive oxygen species and oxidase activity, but reduced anti-oxidase activity. Mechanistically, we found that NGAL decreased the expression of integrin ß3, but not the expression of integrin avß3 and avß5, thus inhibiting the downstream protein AKT. When we used the constitutively activated AKT overexpression adenovirus to activate AKT, the deteriorated phenotype by NGAL was counteracted. CONCLUSIONS NGAL can directly affect cardiomyocytes and cause cardiomyocyte deteriorated hypoxia injury through inhibiting integrin ß3 signaling.

1583 related Products with: Neutrophil Gelatinase-Associated Lipocalin2 Exaggerates Cardiomyocyte Hypoxia Injury by Inhibiting Integrin β3 Signaling.

Rabbit Anti-Integrin beta Rabbit Anti-Integrin alph Rabbit Anti-Integrin β2 Rabbit Anti-Neutrophil El Rabbit Anti-Integrin β2 Rabbit Anti-Neutrophil El Integrin â3 (Phospho Tyr Rabbit Anti-Integrin alph p130Cas-associated protei CD41 Integrin alpha 2b an Rabbit Anti-Integrin alph Mouse anti human Integrin

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Analysis of Novel Cardiovascular Biomarkers in Patients With Pulmonary Hypertension (PH).

Due to the non-specific clinical presentation of patients with pulmonary hypertension (PH), diagnosis is often delayed, consequently resulting in limited therapeutic success and an impaired prognosis. In this trial, we analysed the plasma concentrations of novel cardiovascular biomarkers that reflect different pathobiological pathways (sST2: soluble suppression of tumorigenicity 2, H-FABP: heart type fatty acid binding protein, suPAR: soluble urokinase plasminogen activator receptor and GDF-15: growth-differentiation factor-15) potentially involved in PH associated vascular and right ventricular remodelling. Thus, these markers could contribute to the development of a non-invasive approach for diagnosis and therapy surveillance of PH patients in the future.

1821 related Products with: Analysis of Novel Cardiovascular Biomarkers in Patients With Pulmonary Hypertension (PH).

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Acupuncture attenuates renal interstitial fibrosis via the TGF‑β/Smad pathway.

Acupuncture is one of the most useful tools in complimentary medicine, and has demonstrated potential value for treating chronic renal failure (CRF). However, the underlying mechanisms for its therapeutic effect remain unknown. In the present study, the effects of acupuncture on renal interstitial fibrosis (RIF) were explored in a rabbit model of CRF. Rabbits were assigned to the following five groups: sham, model, losartan potassium (Posi), acupuncture (Acup) and acupuncture+inhibitor (Acup+Inhib) groups. The CRF rabbits were administered a drug or/and acupuncture on Shenshu, Mingmen and Pishu. The body weights, urine protein, serum creatinine (SCr) and blood urea nitrogen (BUN) levels of the rabbits were measured. Transforming growth factor β (TGF‑β), integrin‑linked kinase (ILK) and Smad3 expression were detected by qRT‑PCR. Tumor necrosis factor‑α (TNF‑α) and endothelial nitric oxide synthase (eNOS) expression were analyzed by western blot methods. The concentrations of TGF‑β, IL‑8, TNF‑α and IL‑1β in blood serum were detected using ELISA kits. In addition, pathological characteristics of the rabbit tissues were evaluated by H&E and Masson's trichrome staining methods, and TGF‑β expression was detected by immunohistochemistry (IHC) assays. Results showing decreased body weights and increased urine protein, SCr and BUN levels confirmed that the CRF model had been successfully constructed. It was also found that acupuncture significantly reduced the levels of TNF‑α, Smad3, ILK and TGF‑β expression, dramatically decreased the concentrations of TGF‑β, IL‑8, TNF‑α and IL‑1β in blood serum, and significantly increased eNOS expression in the CRF model rabbits by affecting the TGF‑β/Smad signaling pathway. In addition, it was demonstrated that acupuncture could relieve RIF by affecting the TGF‑β/Smad pathway. These observations indicate that acupuncture may be useful for treating CRF, and suggest the TGF‑β/Smad pathway as a target for CRF therapy.

1690 related Products with: Acupuncture attenuates renal interstitial fibrosis via the TGF‑β/Smad pathway.

Rabbit Anti-Renalase Poly Viral antibodies: anti-H Goat Anti-Human Tissue Fa Smad2 (Phospho Ser467) An Rabbit Anti-Renalase Poly anti Cortical thymocytes Renal carcinoma and norma Smad2 Polyclonal Ab 100 u Goat Anti-Human, Mouse Re Filgrastim (rHuG-CSF) FDA Standard Frozen Tissu Rabbit anti Smad2 (pThr22

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Performance of serological tests available in Brazil for the diagnosis of human visceral leishmaniasis.

Visceral leishmaniasis (VL) is the most severe form of leishmaniasis and is potentially fatal if not diagnosed and treated. Accurate and timely diagnosis is considered one of the pillars needed for the reduction in disease-related lethality. Brazil is currently one of the three eco-epidemiological hotspots for this disease. Several serological tests are commercially available in this country for VL diagnosis, although information on the performance of these tests is fragmented and insufficient. The aim of this study was to directly compare the performance of six commercial kits: three enzyme-linked immunosorbent assays (ELISAs), two immunofluorescence antibody tests (IFATs), one immunochromatographic test (ICT), besides one ICT, currently not commercially available in Brazil and one in-house direct agglutination test (DAT-LPC), not yet marketed.

1638 related Products with: Performance of serological tests available in Brazil for the diagnosis of human visceral leishmaniasis.

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Xuezhitong capsule, an extract of , exhibits reverse cholesterol transport and accompanies high-density lipoprotein levels to protect against hyperlipidemia in ApoE mice.

Xuezhitong capsules (XZT) are derived from Xie Bai and used for abnormal lipid homeostasis treatment through maintained metabolic balance. However, their mechanisms are largely unknown. Here, we mainly assessed the contribution of reverse cholesterol transport (RCT) and the accompanying increase in the high-density lipoprotein (HDL) effects of XZT to cholesterol dysfunction amelioration in mice.

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Diagnostic Value Of Fecal B-cell Activating Factor in Patients with Abdominal Discomfort.

Fecal calprotectin has successfully been widely recommended as a sensitive biomarker of inflammatory bowel diseases (IBD). Recently, we have identified an excellent new fecal biomarker, B-cell activating factor (BAFF), as effective as fecal calprotectin for diagnosing intestinal inflammation. Here in this study, we sought to investigate the potential of fecal BAFF as a screening marker for gastrointestinal inflammation and neoplasms in patients with abdominal discomfort.

2559 related Products with: Diagnostic Value Of Fecal B-cell Activating Factor in Patients with Abdominal Discomfort.

BAFF (B cell activating f BAFF (B cell activating f Macrophage Colony Stimula BAFF(B cell activating fa BAFF (B cell activating f BAFF (B cell activating f BAFF (B cell activating f BAFF (B cell activating f BAFF(B cell activating fa BAFF (B cell activating f Macrophage Colony Stimula BAFF (B cell activating f

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Leukocyte Mitochondrial DNA Copy Number and Risk of Thyroid Cancer: A Two-Stage Case-Control Study.

Mitochondrial DNA copy number (mtDNA-CN) may contribute to the development of various cancer types in a tumor-specific manner. However, little is known about whether leukocyte mtDNA content confers susceptibility to thyroid cancer (TC). This study aimed to investigate the associations of leukocyte mtDNA-CN with the risk and clinicopathological features of TC in a Chinese population. In this two-stage case-control study with a total of 402 TC patients and 406 controls, leukocyte mtDNA-CN content was measured with a quantitative PCR method. In a subset of 100 cases and 100 controls, levels of leukocyte 8-hydroxy-2'-deoxyguanosine (8-OHdG) and plasma malondialdehyde, as two biomarkers for oxidative stress, were determined by ELISA and colorimetric kits, respectively. In a combined analysis of discovery and validation sets, high mtDNA-CN content was positively associated with increased TC risk, after adjusting for confounders (OR for per SD increment: 1.43; 95%CI, 1.23-1.66; < 0.001; OR for tertile 3 vs. tertile 1: 2.10; 95%CI, 1.48-3.00; < 0.001). This linear dose-response relationship was more pronounced in subtype analyses for papillary and follicular thyroid carcinoma ( < 0.001 for all), as well as in subgroup analyses for subjects with overweight and obesity ( = 0.015). In TC patient, we observed the positive correlations of mtDNA-CN with advanced TNM stage ( = 0.006) and the presence of lymph node metastasis ( = 0.012). Leukocyte mtDNA-CN content was also identified to increase with the levels of leukocyte 8-OHdG ( < 0.001), a biomarker for oxidative DNA damage. Our data suggest that the increase in leukocyte mtDNA-CN content may correlate with oxidative DNA damage, and serve as an independent risk factor for TC.

2850 related Products with: Leukocyte Mitochondrial DNA Copy Number and Risk of Thyroid Cancer: A Two-Stage Case-Control Study.

Thyroid cancer test tissu Thyroid cancer test tissu Multiple types of cancer Rectal cancer test tissue Bone cancer test tissue a Breast cancer test tissue Liver cancer tissue array Endometrial cancer test t Ovary cancer test tissue Thyroid cancer tissue arr Thyroid medullary cancer Liver cancer test tissue

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Association of IL-1 and TNF-α Levels in Endometrial Secretion and Success of Embryo Transfer in IVF/ICSI Cycles.

In this work, we have determined the levels of interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-α), which function as cytokines in endometrial receptivity, through the endometrial secretion within the eligible individuals and thus studied their relationships with the success or failure of pregnancy in fertilization/intra cytoplasmic sperm injection (IVF/ICSI) cycles.

1353 related Products with: Association of IL-1 and TNF-α Levels in Endometrial Secretion and Success of Embryo Transfer in IVF/ICSI Cycles.

(7’-Benzyloxy-indolymet Rabbit Anti-Integrin alph Rabbit Anti-Insulin Recep Rabbit Anti-ING1 p33 Poly Rabbit Anti-Insulin Polyc Rabbit Anti-G protein alp Inhibitory mouse monoclo Rabbit Anti-NOS-2 iNOS Po Rabbit Anti-IAA (Indole-3 Rabbit Anti-Integrin alph Rabbit Anti-ING1 p33 Poly Rabbit Anti-Insulin Polyc

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Zinc Deficiency Promotes Testicular Cell Apoptosis in Mice.

Zinc (Zn) plays an important role in spermatogenesis, and carbon tetrachloride (CCl) induces testicular oxidative damage and cell death. The objective of the present study was to define the effects of Zn deficiency in combination with CCl treatment on testicular apoptosis and the associated mechanisms. Mice were fed the following diets with three different Zn levels for 6 weeks: normal zinc (ZN) diet (30 mg Zn/kg), zinc-deficient (ZD) diet (2 mg Zn/kg), and adequate zinc (ZA) diet (100 mg Zn/kg). Beginning in the third week, CCl was intraperitoneally injected into half of the mice in each diet group six times over 3 weeks. We found that Zn was distributed in various tissues and organs in normal mice and that the zinc content in the testis of normal mice was high. The Zn-deficient diet reduced the zinc concentration in the testis tissue, and the testicular/body weight ratio significantly decreased. Moreover, the TUNEL results proved that CCl stimulation of mice fed with a zinc-deficient diet caused marked apoptosis of testicular cells. Furthermore, the ROS levels in the testes obviously increased after Zn-deficient mice were stimulated with CCl, whereas reduced glutathione (GSH) and glutathione peroxidase (GSH-Px) showed reduced activities. In addition, proteins associated with the apoptosis signaling pathway were detected with ELISA kits. P-p53, cleaved caspase-3, cleaved PRAP, p-Bad, p-JNK, p-ERK, and p-NF-κB p65 increased by varying degrees under zinc deficiency or CCl stimulation. All the data indicated that Zn deficiency significantly enhanced the harm to the testis induced by oxidative stress and damage, while CCl stimulation exacerbated the oxidative damage in testicular cells, leading to apoptosis through the activation of p53, MAPK, and NF-κB.

1900 related Products with: Zinc Deficiency Promotes Testicular Cell Apoptosis in Mice.

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