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Gingko Biloba protects cardiomyocytes against acute doxorubicin induced cardiotoxicity by suppressing oxidative stress.

To evaluate the cardio-protective effect of Ginkgo Biloba (GB) on doxorubicin induced-cardiotoxicity.

1861 related Products with: Gingko Biloba protects cardiomyocytes against acute doxorubicin induced cardiotoxicity by suppressing oxidative stress.

OXI TEK (Oxidative Stress Transcription factors: O 8 Isoprostane oxidative s Anti AGO2 Human, Monoclon Jurkat Cell Extract (Indu Anti CML Monoclonal Antib OxiSelect™ Cellular UV- Human Epstein-Barr Virus steroidogenic acute regul Bovine prolactin-induced Anti AGO2 Human, Monoclon Doxorubicin.HCl

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Epidemiological survey of fasciolosis in yaks and sheep living on the Qinghai-Tibet plateau, China.

Fasciolosis is one of the biggest threats to livestock and human population. For this purpose, the seroprevalence of Fasciola hepatica was investigated in yaks and sheep living on the Qinghai-Tibet plateau, China by piloting commercial ELISA kits. A total of 3276 yaks and 1092 sheep were incorporated in this study. The prevalence of the parasite in yaks and sheep was 38.3% and 26.4%, respectively. The serological results revealed a relatively high prevalence of F. hepatica infection in yaks and sheep, respectively. The present study may greatly contribute to the prevention of this parasitic zoonosis and great importance should be given to the potential threat caused by F. hepatica in this special plateau.

1794 related Products with: Epidemiological survey of fasciolosis in yaks and sheep living on the Qinghai-Tibet plateau, China.

Colon cancer survey tissu Cervix cancer survey tiss Kidney cancer survey tiss Breast tumor survey tissu Lung cancer survey tissue Breast tumor survey tissu Liver cancer survey tissu Ovary cancer survey tissu MultiGene Gradient therm Breast tumor survey tissu FDA Standard Frozen Tissu Sheep Anti-Theophylline 3

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Influence of lncRNA-MALAT1 on neuronal apoptosis in rats with cerebral infarction through regulating the ERK/MAPK signaling pathway.

To investigate the regulatory effect of long non-coding ribonucleic acid (lncRNA)-metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) on the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) signaling pathway, and to explore its influence on neuronal apoptosis in rats with cerebral infarction.

1639 related Products with: Influence of lncRNA-MALAT1 on neuronal apoptosis in rats with cerebral infarction through regulating the ERK/MAPK signaling pathway.

GPCR Signaling to MAPK ER p53 Signaling Phospho-Spe Apoptosis Phospho-Specifi ERK Signaling Phospho-Spe DiscoveryPak™ Hedgehog T-Cell Receptor Signaling IGF-1R Signaling Phospho- NF-kB II Phospho-Specific AMPK Signaling Phospho-Sp ErbB Her Signaling Phosph MAPK Phospho-Specific Arr Apoptosis antibody array

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Evaluation of serum apelin-13 and apelin-36 concentrations in preeclamptic pregnancies.

Recent studies suggest that apelin can be a novel potential therapeutic mediator to improve the diagnosis, and treatment of preeclampsia. This study aimed to investigate the association of serum apelin-13 and apelin-36 with preeclampsia and to detect their relationship with preeclampsia-associated perinatal morbidity.

2940 related Products with: Evaluation of serum apelin-13 and apelin-36 concentrations in preeclamptic pregnancies.

Sterile filtered fetal bo Sterile filtered fetal bo 3-Amino-1-methyl-5H-pyrid Sterile filtered fetal bo Sterile filtered rat ser 1-Benzyl-3-(3-chloropropo apelin Human interleukin 2(IL-2) Apelin receptor antibody Rabbit Serum US Origin In 6 Chloro 3 indolyl beta D Sterile filtered fetal bo

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Follistatin‑like protein 1 knockdown elicits human gastric cancer cell apoptosis via a STAT6‑dependent pathway.

Gastric cancer is an aggressive disease and a common cause of cancer‑associated mortality worldwide. Recent studies have indicated that follistatin‑like protein 1 (FSTL‑1) is expressed and serves essential roles in tumorigenesis; however, the specific functional mechanism of FSTL‑1 in gastric cancer progression remains ambiguous. CellTiter‑Glo Luminescent Cell Viability and lactate dehydrogenase assays were used to measure cell survival and cell cytotoxicity, respectively. Cell apoptosis was ascertained using the Cell Death Detection ELISA assay and caspase‑3/9 activity kits. Reverse transcription‑quantitative polymerase chain reaction and western blotting were used to detect the expression levels of FSTL‑1. The present study confirmed that FSTL‑1 was highly expressed in gastric cancer cells compared with in control cells. Subsequently, FSTL‑1 inhibition by small interfering RNA significantly reduced cancer cell survival and induced cytotoxic effects. In addition, knockdown of FSTL‑1 in gastric cancer cells promoted apoptosis by increasing caspase‑3 and caspase‑9 expression. A decrease in signal transducer and activator of transcription 6 (STAT6) phosphorylation was observed in FSTL‑1 knockdown cells, and the results confirmed that STAT6 phosphorylation was essential for FSTL‑1 knockdown‑induced cell apoptosis of cancer cells. Taken together, these results demonstrated that FSTL‑1 knockdown may promote cell apoptosis via the STAT6 signaling pathway; therefore, FSTL1 may be considered a novel diagnostic and therapeutic target for gastric cancer.

2796 related Products with: Follistatin‑like protein 1 knockdown elicits human gastric cancer cell apoptosis via a STAT6‑dependent pathway.

Rabbit Anti-IEX1 Differen Breast cancer membrane pr Rabbit Anti-Cell death in cell cycle progression 2 Rabbit Anti-Cell death in Rabbit Anti-IEX1 Differen B-cell linker protein ant Myotubularin related prot stress-associated endopla Rabbit Anti-Fascin Actin Docking protein 3 antibod Rabbit Anti-Apoptosis enh

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High-intensity interval training improved fasting blood glucose and lipid profiles in type 2 diabetic rats more than endurance training; possible involvement of irisin and betatrophin.

In this study, we aimed to investigate the effects of 10 weeks of high-intensity interval training (HIIT) and endurance training (END) on irisin, betatrophin, insulin, fasting blood glucose (FBG) concentrations, and lipid profiles in diabetic rats.

1345 related Products with: High-intensity interval training improved fasting blood glucose and lipid profiles in type 2 diabetic rats more than endurance training; possible involvement of irisin and betatrophin.

Androst-4-ene-3,6,17-trio Polyclonal Antibody Gluco Androgen Receptor Androgen Receptor Ab 1 High density (208 cores), Polyclonal Antibody Gluco Advanced Airway Intubatio High density (188 cases 2 Androgen Receptor Ab-1 An Polyclonal Antibody Gluco Bovine Androstenedione,AS Androgen Receptor Antibod

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Serum regucalcin is a useful indicator of liver injury severity in patients with hepatitis B virus-related liver diseases.

Regucalcin is a soluble protein that is principally expressed in hepatocytes. Studies of regucalcin have mainly been conducted in animals due to a lack of commercially available kits. We aimed to develop an enzyme-linked immunosorbent assay (ELISA) to quantify serum regucalcin in patients with hepatitis B virus (HBV)-related disease. High-titer monoclonal antibodies and a polyclonal antibody to regucalcin were produced, a double-antibody sandwich ELISA method was established, and serum regucalcin was determined in 47 chronic hepatitis B (CHB) patients, 91 HBV-related acute-on-chronic liver failure (HBV-ACLF) patients, and 33 healthy controls. The ELISA demonstrated an appropriate linear range, and high levels of reproducibility, sensitivity, specificity, accuracy, and stability. The median serum regucalcin concentrations in HBV-ACLF and CHB patients were 5.46 and 3.76 ng/mL, respectively (P<0.01), which were much higher than in healthy controls (1.72 ng/mL, both P<0.01). For the differentiation of CHB patients and healthy controls, the area under curve (AUC) was 0.86 with a cut-off of 2.42 ng/mL, 85.7% sensitivity, and 78.8% specificity. In contrast, the AUC of alanine aminotransferase (ALT) was lower (AUC=0.80, P=0.01). To differentiate ACLF from CHB, the AUC was 0.72 with a cut-off of 4.26 ng/mL, 77.0% sensitivity, and 61.2% specificity while the AUC of ALT was 0.41 (P=0.07). Thus, we have developed an ELISA that is suitable for measuring serum regucalcin and have shown that serum regucalcin increased with the severity of liver injury due to HBV-related diseases, such that it appears to be more useful than ALT as a marker of liver injury.

2016 related Products with: Serum regucalcin is a useful indicator of liver injury severity in patients with hepatitis B virus-related liver diseases.

Normal liver and hepatoce Multiple diseases of live ENZYMATIC ASSAY KITS (CH LIVER DISEASES Total Bile Liver cancer and normal t GI cancer (esophageal, ga Rabbit Anti-Hepatitis C V LIVER DISEASES Total Bile Liver cancer and adjacent Liver cancer and normal t Alkaline Phospatase (ALP) Rabbit Anti-Hepatitis C V

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LncRNA H19/microRNA-675/PPARα axis regulates liver cell injury and energy metabolism remodelling induced by hepatitis B X protein via Akt/mTOR signalling.

Emerging evidence indicates that the lncRNAs/microRNA/mRNA axis plays important roles in a variety of diseases. This study was aimed to investigate the potential roles and underlying molecular mechanisms of lncRNA H19 and H19-derived miR-675 in regulating hepatitis B virus (HBV)-associated liver injury. mRNA and miR-675 levels were determined by quantitative real-time PCR (qRT-PCR), protein levels were determined by western blot, cell viability was measured by the MTT assay, cell apoptosis was measured by flow cytometry, inflammatory cytokine production was determined by ELISA, oxidative stress and energy metabolism were assessed by commercial kits, and the target relationship between PPARα and miR-675 was confirmed by the dual-luciferase reporter assay. The results showed that the expression of lncRNA H19 and miR-675 was up-regulated in patients with chronic hepatitis B (n = 20). Inhibition of lncRNA H19 or miR-675 in L02 cells increased cell viability, suppressed hepatitis B X protein (HBx)-induced cell apoptosis, inflammatory cytokine production, and oxidative stress, and remodelled energy metabolism. Furthermore, PPARα was found to be a target gene of miR-675. The expression of PPARα was down-regulated in patients with chronic hepatitis B, and there was a negative correlation between the expression of lncRNA H19 and PPARα, or between miR-675 and PPARα. Moreover, by knocking down the expression of PPARα, the actions (apoptosis, inflammatory factors, oxidative stress, and energy metabolism) of lncRNA H19 or miR-675 inhibition in HBx-induced L02 cells were at least partially reversed. In addition, HBx-induced elevated levels of p-Akt, p-Akt and p-mTOR were down-regulated by lncRNA H19 or miR-675 inhibition. Furthermore, PPARα knockdown partly reversed the down-regulated effects of H19 or miR-675 inhibition. Taken together, these data indicate that the lncRNA H19/miR-675/PPARα axis regulates liver cell injury and energy metabolism remodelling induced by HBx, which may be related to the modulation of Akt/mTOR signalling.

2639 related Products with: LncRNA H19/microRNA-675/PPARα axis regulates liver cell injury and energy metabolism remodelling induced by hepatitis B X protein via Akt/mTOR signalling.

Leptin ELISA Kit, Rat Lep Rabbit Anti-Human B-cell Cell Meter™ Cell Viabil Anti-BTG1(B-cell transloc CellQuanti-Blue™ Cell V BCMA (B cell maturation p Octyl â D 1 thioglucopyr Rabbit Anti-Rat Androgen Rabbit Anti-Cell death in Bovine prolactin-induced Cell Meter™ Cell Viabil Anti C Reactive Protein A

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Imbalance between angiogenic and anti-angiogenic factors in sera from patients with large-vessel vasculitis.

To investigate serum levels of a panel of angiogenic inducers (VEGF, FGF-2, Angiopoietin 1, -2, soluble VCAM-1) and inhibitors (angiostatin, endostatin, pentraxin-3) in patients with giant cell arteritis (GCA) and Takayasu's arteritis (TAK), in order to gain further insights into the molecular mechanisms driving angiogenesis dysregulation in large-vessel vasculitis (LVV).

1014 related Products with: Imbalance between angiogenic and anti-angiogenic factors in sera from patients with large-vessel vasculitis.

Angiogenesis (Human) Quan Anti-AGGF1(Angiogenic fac Angiogenesis (Human) Quan Anti AGGF1(Angiogenic fac Angiogenesis (Human) Quan Anti AGGF1(Angiogenic fac Anti-AGGF1(Angiogenic fac Goat Anti-Human TGIF2, (i Goat Anti-Human AS160 TBC Goat Anti-Human Histamine Goat Anti-Influenza A H3N Mouse Anti-Insulin(1G11)

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Anti-inflammatory activities of Makino: combined in vitro and in silico investigations.

Makino (SG) is one of the important plant origins of Sigesbeckiae herba and has been widely used for the treatment of chronic inflammatory diseases in China. However, the underlying anti-inflammatory mechanism of SG is rarely investigated and reported. There are more than 40 kinds of chemical constituents in SG, but the action of the bioactive compounds of SG is still unclear. Therefore, we aimed to systemically investigate the mechanisms behind the anti-inflammatory properties of SG by combining in vitro and in silico investigations.

1754 related Products with: Anti-inflammatory activities of Makino: combined in vitro and in silico investigations.

Goat Anti-Human TACR1, (i Goat Anti-Human APBA1 MIN Mouse Anti-Human TSH, int Rabbit Anti-Integrin beta Rabbit Anti-Insulin Polyc Goat Anti-Human ABCD3, (i Goat Anti-Human, Mouse PT Rabbit Anti-Integrin β2 Goat Anti- PGBD1, (intern Goat Anti- NAT2 (aa182-19 Colon carcinoma tissue ar Mouse Anti-Influenza-B

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