Endothelin1 ET11850 Prepro Human Western Blot Kit productsSearch results for: Endothelin1 ET11850 Prepro Human Western Blot Kit
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Interactions of endothelin-1 with dexamethasone in primary cultured human trabecular meshwork cells.
Concentrations of aqueous humor endothelin (ET)-1 are increased in patients with primary open-angle glaucoma (POAG) as well as in animal models of glaucoma. Glucocorticoids have also been associated with glaucoma, in that topical administration of glucocorticoids can increase intraocular pressure by increasing outflow resistance in the trabecular meshwork (TM) in some individuals. Recent research has shown that dexamethasone (Dex), a synthetic glucocorticoid, can increase the release of ET-1 from human nonpigmented ciliary epithelial (HNPE) cells, a source of aqueous ET-1. In the present study, the downstream interaction of ET-1 with Dex in target TM cells, an action that may alter outflow resistance, was investigated.Xinyu Zhang, Abbot F Clark, Thomas Yorio
