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Search results for: Human Angiogenin ELISA Kit

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#35536076   // To Up

Plasma Angiopoietin-2 as a Promising Biomarker for the Prognosis of Acute Pulmonary Embolism.

Endothelial damage is one of the pathogenic conditions of acute pulmonary embolism (APE). The essential role of angiogenin, ribonuclease A family, member 2 (Ang-2) in APE remains unclear. This study aimed to investigate the predictive value of Ang-2 in the clinical outcomes of patients with APE.
Shenshen Huang, Yingwei Zhu, Yaqing Ma, Jiayong Qiu, Yuxia Sun, Yimin Mao, Yongmei Zhang

2573 related Products with: Plasma Angiopoietin-2 as a Promising Biomarker for the Prognosis of Acute Pulmonary Embolism.

1,000 tests200ul1.0mg200ul100Tests200ul200ul2500 assays

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#31852251   2019/12/18 To Up

CSF angiogenin levels in amyotrophic lateral Sclerosis-Frontotemporal dementia spectrum.

Angiogenin (ANG) is a pro-angiogenic and neurotrophic factor with an important role in stress-induced injury, by promoting neovascularization and neuronal survival. Identification of loss-of-function mutations and evidence of beneficial effect of ANG administration in transgenic SOD1 mice have linked ANG to the pathogenesis of Amyotrophic Lateral Sclerosis (ALS), stimulating interest in considering circulating ANG levels as an ALS disease biomarker although robust evidence is still lacking. Aim of our study was to assess differences of ANG levels in the cerebrospinal fluid (CSF) of a large cohort of patients with ALS and frontotemporal dementia (FTD) compared to controls and to explore correlations between ANG content and disease-related clinical variables. ANG levels were measured in CSF samples using a commercially available ELISA kit in 88 patients affected with ALS and/or FTD and 46 unrelated individuals (control group). ANG levels didn't differ significantly between cases and controls. Patients with FTD or ALS-FTD showed significantly increased CSF concentration of ANG compared to ALS patients without dementia and controls in a multivariate regression model ( < 0.001). No correlations were found in ALS/FTD patients between ANG levels and clinical parameters, including age, presence of repeat expansion, body mass index (BMI). our findings highlight a role of ANG as CSF biomarker useful to identify ALS patients with concurrent FTD and suggest that it should be further explored as potential biomarker for FTD.
C Morelli, C Tiloca, C Colombrita, A Zambon, D Soranna, A Lafronza, F Solca, L Carelli, B Poletti, A Doretti, F Verde, L Maderna, N Ticozzi, A Ratti, V Silani

1292 related Products with: CSF angiogenin levels in amyotrophic lateral Sclerosis-Frontotemporal dementia spectrum.

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#22449478   2012/03/15 To Up

Decreased serum angiogenin level in Alzheimer's disease.

It has been suggested that Alzheimer's disease (AD) is mediated by pathological angiogenesis. Vascular endothelial growth factor (VEGF), transforming growth factor β (TGF-β), and tumor necrosis factor α (TNF -α) may play important roles in inflammation and angiogenesis through effects on inflammatory cell infiltration or neovascularization in AD pathogenesis. A few studies on the roles of VEGF in AD have been reported recently. But, the results were inconsistent. Angiogenin, which is suspected to have a similar function as VEGF, however, has not yet been studied in patients with AD.
Yong Nam Kim, Do Hoon Kim

1516 related Products with: Decreased serum angiogenin level in Alzheimer's disease.

96 tests96 tests96 tests96 tests500 ml50 ml500 ml10 ml

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