Search results for: Human SDF-1 alpha ELISA ELISA
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TGFβ3 recruits endogenous mesenchymal stem cells to initiate bone regeneration.The recruitment of a sufficient number of endogenous mesenchymal stem cells (MSCs) is the first stage of in-situ tissue regeneration. Transforming growth factor beta-3 (TGFβ3) could recruit stem or progenitor cells and endothelial cells to participate in tissue regeneration. However, the mechanism of TGFβ3 recruiting MSCs toward bone regeneration has remained obscure.
2013 related Products with: TGFβ3 recruits endogenous mesenchymal stem cells to initiate bone regeneration.Rat Mesenchymal Stem Cell Macrophage Colony Stimula Macrophage Colony Stimula Rat Mesenchymal Cells Rat Mesenchymal Stem Cell Mesenchymal Stem Cell Adi Mesenchymal Stem Cell Ost Human Tonsil Microvascula Stemez hN2 Human Neuron D AccuzolTM Total RNA Extra 129 Mouse Embryonic Stem Topoisomerase II; Clone
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Overexpression of hypoxia-inducible factor 1 alpha improves immunomodulation by dental mesenchymal stem cells.Human dental mesenchymal stem cells (MSCs) are considered as highly accessible and attractive MSCs for use in regenerative medicine, yet some of their features are not as well characterized as other MSCs. Hypoxia-preconditioning and hypoxia-inducible factor 1 (HIF-1) alpha overexpression significantly improves MSC therapeutics, but the mechanisms involved are not fully understood. In the present study, we characterize immunomodulatory properties of dental MSCs and determine changes in their ability to modulate adaptive and innate immune populations after HIF-1 alpha overexpression.
2900 related Products with: Overexpression of hypoxia-inducible factor 1 alpha improves immunomodulation by dental mesenchymal stem cells.Rat Mesenchymal Stem Cell Human Tumor Necrosis Fact Macrophage Colony Stimula Macrophage Colony Stimula Contact Factors: Human al ELISA Kit for Tumor Necr Epidermal Growth Factor ( Epidermal Growth Factor ( Growth Differentiation Fa CELLKINES MACROPHAGE COLO MACROPHAGE COLONY STIMULA CELLKINES MACROPHAGE COLO
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A novel recombinant antibody specific to full-length stromal derived factor-1 for potential application in biomarker studies.Stromal derived factor-1α (SDF-1α/CXCL12) is a chemokine that is up-regulated in diseases characterised by tissue hypoxia, including myocardial infarction, ischaemic cardiomyopathy and remote ischaemic conditioning (RIC), a technique of cyclical, non-injurious ischaemia applied remote from the heart that protects the heat from lethal ischaemia-reperfusion injury. Accordingly, there is considerable interest in SDF-1α as a potential biomarker of such conditions. However, SDF-1α is rapidly degraded and inactivated by dipeptidyl peptidase 4 and other peptidases, and the kinetics of intact SDF-1α remain unknown.
2074 related Products with: A novel recombinant antibody specific to full-length stromal derived factor-1 for potential application in biomarker studies.TGF beta induced factor 2 thymic dendritic cell-der MOUSE ANTI BOVINE ROTAVIR Fibroblast Growth Factor Fibroblast Growth Factor Growth Differentiation Fa INPP5F antibody Source Ra Interferon alpha-8 antibo Interferon alpha-6 antibo succinate-CoA ligase, GDP PABP1-dependent poly A-sp interleukin 17 receptor C
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Differing local and systemic inflammatory burden in polyarticular psoriatic arthritis and rheumatoid arthritis patients on anti-TNF treatment in clinical remission.To analyse clinical, serological and sonographic differences between rheumatoid arthritis (RA) and polyarticular psoriatic arthritis (PsA) patients on anti-TNF therapy in clinical remission.
2439 related Products with: Differing local and systemic inflammatory burden in polyarticular psoriatic arthritis and rheumatoid arthritis patients on anti-TNF treatment in clinical remission.Multiple organ cancer tis Lung cancer tissue array Colon cancer tissue array Kidney cancer tissue arra Ovary cancer tissue array Bladder cancer tissue arr Multiple organ tumor and Bladder cancer tissue arr Bladder cancer tissue arr Human normal bone and ost Breast cancer and matched Breast cancer tissue arra
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Diffuse-type gastric cancer cells switch their driver pathways from FGFR2 signaling to SDF1/CXCR4 axis in hypoxic tumor microenvironments.Cancer-associated fibroblasts (CAFs) have been considered to play an important role for tumor progression of cancer. Solid tumors contain heterogeneous distribution of oxygen in their microenvironments. This study investigated the growth signaling of gastric cancer (GC) cells in focus on the interaction with CAFs and GC cells under normoxia and hypoxia. Four diffuse-type GC cell lines, two intestinal-type GC cell lines and three CAF cell lines were used. Cells were examined for expression of C-X-C chemokine receptor 4 (CXCR4), fibroblast growth factor receptor 2 (FGFR2) and stromal-derived factor 1 (SDF1) by RT-PCR, western blot, ELISA and immunohistochemical staining of xenografted tumors. GC cell proliferation was examined under hypoxia in the presence or absence of CAFs, a FGFR2 inhibitor, a CXCR4 inhibitor and HIF1α siRNA. Proliferation of diffuse-type GC cells, but not intestinal-type GC cells, was significantly increased by CAFs. CXCR4 expression by diffuse-type GC cells was significantly increased in hypoxia, while FGFR2 expression was decreased. CXCR4 expression was correlated with hypoxic microenvironment of xenografted tumor, but FGFR2 expression was not. FGFR2 inhibition significantly decreased the growth-stimulating activity of CAFs for diffuse-type GC cells in normoxia. In contrast, CXCR4 inhibition significantly decreased the growth-stimulating activity of CAFs in hypoxia. SDF1 production by CAFs was increased in hypoxia, while cancer cells did not produce SDF1. HIF1 siRNA significantly decreased both CXCR4 expression by diffuse-type GC cells and SDF1 production by CAFs. These findings suggest that diffuse-type GC cells might switch their driver pathways from FGFR2 signaling to SDF1/CXCR4 axis through HIF1 in hypoxic tumor microenvironments.
2825 related Products with: Diffuse-type gastric cancer cells switch their driver pathways from FGFR2 signaling to SDF1/CXCR4 axis in hypoxic tumor microenvironments.High density (188 cases 2 High density (188 cases 2 Multiple organ cancer and GI cancer (esophageal, ga Multiple types of kidney High density (208 cores), Liver cancer tissue array Multiple cancer (12 type) Multiple cancer (12 type) Multiple types of cancer Multiple tumor and normal Oral squamous cell cancer
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CXCR4 pharmacogical inhibition reduces bone and soft tissue metastatic burden by affecting tumor growth and tumorigenic potential in prostate cancer preclinical models.The majority of prostate cancer (Pca) patient morbidity can be attributed to bone metastatic events, which poses a significant clinical obstacle. Therefore, a better understanding of this phenomenon is imperative and might help to develop novel therapeutic strategies. Stromal cell-derived factor 1α (SDF-1α) and its receptor CXCR4 have been implicated as regulators of bone resorption and bone metastatic development, suggesting that agents able to suppress this signaling pathway may be used as pharmacological treatments. In this study we studied if two CXCR4 receptor antagonists, Plerixafor and CTE9908, may affect bone metastatic disease induced by Pca in preclinical experimental models
1198 related Products with: CXCR4 pharmacogical inhibition reduces bone and soft tissue metastatic burden by affecting tumor growth and tumorigenic potential in prostate cancer preclinical models.Prostate cancer tissue ar Prostate cancer tissue ar Prostate cancer tissue ar Prostate cancer tissue ar Prostate cancer, adjacent Bone marrow tumor and adj Breast cancer and matched Breast cancer and matched Breast cancer and matched Breast cancer tissue arra Mid advanced stage kidney Lung cancer tissue array
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Gemcitabine plus sorafenib versus gemcitabine alone in advanced biliary tract cancer: a double-blind placebo-controlled multicentre phase II AIO study with biomarker and serum programme.Since sorafenib has shown activity in different tumour types and gemcitabine regimens improved the outcome for biliary tract cancer (BTC) patients, we evaluated first-line gemcitabine plus sorafenib in a double-blind phase II study.
2622 related Products with: Gemcitabine plus sorafenib versus gemcitabine alone in advanced biliary tract cancer: a double-blind placebo-controlled multicentre phase II AIO study with biomarker and serum programme.Mid advanced stage bladde Mid advanced stage bladde Advanced breast cancer an Middle advanced stage bre Middle advanced stage bre Advanced colon cancer tis Middle advanced stage ute Mid advanced stage uterin Middle advanced stage eso Middle advanced stage eso Mid advanced stage kidney Advanced kidney cancer ti
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The role of SRC1 and SRC2 in steroid-induced SDF1 expression in normal and ectopic endometrium.To compare the expression patterns of steroid receptor coactivators (SRCs) and steroid-induced stromal cell-derived factor 1 (CXCL12 (SDF1)) in normal and ectopic endometrium and to explore the roles of NCOA1 (SRC1) and NCOA2 (SRC2) in the steroid-induced CXCL12 expression in normal and ectopic endometrial stromal cells (ESCs). The NCOA1, NCOA2, NCOA3 (SRC3), and CXCL12 (SDF1)α mRNA levels in normal and ectopic endometrium were analyzed by quantitative real-time PCR. Steroid-induced CXCL12 expression was detected by the ELISA method and the chemotactic activity of conditioned supernatant to monocyte was assessed by the Boyden chamber method before and after the silencing of NCOA1 or NCOA2 with siRNA in normal and ectopic ESCs. The expression of NCOA1 and CXCL12 in ectopic endometrium was significantly greater than that in normal endometrium in the secretory phase. Progesterone (P4) was able to significantly inhibit estradiol (E2)-stimulated CXCL12 expression in normal and ectopic ESCs. The inhibitory rate of P4 in ectopic ESCs at 72 and 96 h was significantly lower than that in normal ESCs. Silencing of NCOA1 but not NCOA2 significantly reduced the E2-induced CXCL12 expression in normal and ectopic ESCs. The ability of P4 to inhibit E2-induced CXCL12 expression and monocyte chemotaxis in normal and ectopic ESCs was significantly attenuated when NCOA2 was silenced. NCOA1 plays a necessary role in E2-induced CXCL12 expression and NCOA2 is required for P4 to inhibit the E2-induced CXCL12 production in normal and ectopic endometrium.
1244 related Products with: The role of SRC1 and SRC2 in steroid-induced SDF1 expression in normal and ectopic endometrium.Endometrium cancer and no Endometrium cancer test t Endometrium cancer tissue Endometrium cancer tissue Anti AGO2 Human, Monoclon Anti AGO2 Mouse, Monoclon Anti AGO2 Human, Monoclon Anti AGO2 Mouse, Monoclon DNA (cytosine 5) methyltr Human Epstein-Barr Virus Jurkat Cell Extract (Indu Jurkat Cell Extract (Indu
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The effect of percutaneous coronary intervention on inflammatory response and endothelial progenitor cell recruitment.Vascular interventions, such as percutaneous coronary interventions (PCI), lead to endothelial damage and cause an inflammatory response. Endothelial progenitor cells (EPC) have been shown to have a prominent role in re-endothelialization and repair following vascular injury. Studies have implicated a role for the chemokine, stromal-cell-derived factor-1 alpha (SDF1-alpha) in the recruitment of circulating EPCs to sites of vascular injury. However, the relationship between the inflammatory response, SDF1-alpha, and EPC levels after PCI is unclear.
2443 related Products with: The effect of percutaneous coronary intervention on inflammatory response and endothelial progenitor cell recruitment.Human Coronary Artery End GFP Expressing Human Coro CD31, Endothelial Cell; CD31, Endothelial Cell; CD34, Endothelial Cell; CD34, Endothelial Cell; CD31, Endothelial Cell; CD34, Endothelial Cell; Cultrex In Vitro Angiogen Human Umbilical Vein Endo GFP Expressing Human Umbi Mitochondria GFP Tag Huma
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[Comparison of immunological profiles between pediatric and adult patients with AIDS in China].To compare the immunological profiles of pediatric and adult patients with AIDS in China.
1423 related Products with: [Comparison of immunological profiles between pediatric and adult patients with AIDS in China].Advanced Airway Intubatio Syringe pump can be contr Interleukin-34 IL34 (N-t Interleukin-34 IL34 anti Sterile filtered goat se Sterile filtered goat se Sterile filtered mouse s Sterile filtered rat ser ING1B antisense ING1B sense Interferon γ p19 INK4D
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