Search results for: Human SDF-1 alpha ELISA ELISA
#29126441 // Save this To Up
TGFβ3 recruits endogenous mesenchymal stem cells to initiate bone regeneration.The recruitment of a sufficient number of endogenous mesenchymal stem cells (MSCs) is the first stage of in-situ tissue regeneration. Transforming growth factor beta-3 (TGFβ3) could recruit stem or progenitor cells and endothelial cells to participate in tissue regeneration. However, the mechanism of TGFβ3 recruiting MSCs toward bone regeneration has remained obscure.
1621 related Products with: TGFβ3 recruits endogenous mesenchymal stem cells to initiate bone regeneration.Rat Mesenchymal Stem Cell Mesenchymal Stem Cell Ost Rat Mesenchymal Stem Cell Macrophage Colony Stimula AccuzolTM Total RNA Extra Mesenchymal Stem Cell Adi Stemez hN2 Human Neuron D Rat Mesenchymal Cells Human Tonsil Microvascula 129 Mouse Embryonic Stem Macrophage Colony Stimula AP-1 Reporter – HEK293
#28962641 // Save this To Up
Overexpression of hypoxia-inducible factor 1 alpha improves immunomodulation by dental mesenchymal stem cells.Human dental mesenchymal stem cells (MSCs) are considered as highly accessible and attractive MSCs for use in regenerative medicine, yet some of their features are not as well characterized as other MSCs. Hypoxia-preconditioning and hypoxia-inducible factor 1 (HIF-1) alpha overexpression significantly improves MSC therapeutics, but the mechanisms involved are not fully understood. In the present study, we characterize immunomodulatory properties of dental MSCs and determine changes in their ability to modulate adaptive and innate immune populations after HIF-1 alpha overexpression.
2915 related Products with: Overexpression of hypoxia-inducible factor 1 alpha improves immunomodulation by dental mesenchymal stem cells.Rat Mesenchymal Stem Cell Contact Factors: Human al Human Tumor Necrosis Fact Macrophage Colony Stimula Macrophage Colony Stimula Sheep Red Blood Cells, Pa Anti-bodywall muscle cell Rabbit Anti-Integrin alph alpha Tubulin 4a antibody Rabbit Anti-Laminin alpha Rabbit Anti-IKK alpha Pol Rabbit Anti-IKK alpha + I
#28379992 // Save this To Up
A novel recombinant antibody specific to full-length stromal derived factor-1 for potential application in biomarker studies.Stromal derived factor-1α (SDF-1α/CXCL12) is a chemokine that is up-regulated in diseases characterised by tissue hypoxia, including myocardial infarction, ischaemic cardiomyopathy and remote ischaemic conditioning (RIC), a technique of cyclical, non-injurious ischaemia applied remote from the heart that protects the heat from lethal ischaemia-reperfusion injury. Accordingly, there is considerable interest in SDF-1α as a potential biomarker of such conditions. However, SDF-1α is rapidly degraded and inactivated by dipeptidyl peptidase 4 and other peptidases, and the kinetics of intact SDF-1α remain unknown.
1280 related Products with: A novel recombinant antibody specific to full-length stromal derived factor-1 for potential application in biomarker studies.thymic dendritic cell-der TGF beta induced factor 2 Transcription factor E3 a Rabbit Anti-TNIP2 ABIN2 T Anti-Apoptosis-Inducing F Rabbit Anti-Cell death in Factor IX antibody Source Fibroblast Growth Factor MOUSE ANTI HUMAN CD19 RPE Rabbit Anti-IAA (Indole-3 Integrin alpha6 antibody Interferon alpha-8 antibo
#27749227 // Save this To Up
Differing local and systemic inflammatory burden in polyarticular psoriatic arthritis and rheumatoid arthritis patients on anti-TNF treatment in clinical remission.To analyse clinical, serological and sonographic differences between rheumatoid arthritis (RA) and polyarticular psoriatic arthritis (PsA) patients on anti-TNF therapy in clinical remission.
1514 related Products with: Differing local and systemic inflammatory burden in polyarticular psoriatic arthritis and rheumatoid arthritis patients on anti-TNF treatment in clinical remission.Thyroid cancer and adenom Stomach cancer tissue arr Lung cancer tissue array, Embryonal tumor test tiss Lung cancer tissue array, Soft tissue malignant tum Colon cancer tissue array Head and neck cancer tiss Rabbit Anti-TNIP2 ABIN2 T Rabbit Anti-TNIP2 ABIN2 T Colon carcinoma tissue ar Breast cancer tissue arra
#26385890 // Save this To Up
Diffuse-type gastric cancer cells switch their driver pathways from FGFR2 signaling to SDF1/CXCR4 axis in hypoxic tumor microenvironments.Cancer-associated fibroblasts (CAFs) have been considered to play an important role for tumor progression of cancer. Solid tumors contain heterogeneous distribution of oxygen in their microenvironments. This study investigated the growth signaling of gastric cancer (GC) cells in focus on the interaction with CAFs and GC cells under normoxia and hypoxia. Four diffuse-type GC cell lines, two intestinal-type GC cell lines and three CAF cell lines were used. Cells were examined for expression of C-X-C chemokine receptor 4 (CXCR4), fibroblast growth factor receptor 2 (FGFR2) and stromal-derived factor 1 (SDF1) by RT-PCR, western blot, ELISA and immunohistochemical staining of xenografted tumors. GC cell proliferation was examined under hypoxia in the presence or absence of CAFs, a FGFR2 inhibitor, a CXCR4 inhibitor and HIF1α siRNA. Proliferation of diffuse-type GC cells, but not intestinal-type GC cells, was significantly increased by CAFs. CXCR4 expression by diffuse-type GC cells was significantly increased in hypoxia, while FGFR2 expression was decreased. CXCR4 expression was correlated with hypoxic microenvironment of xenografted tumor, but FGFR2 expression was not. FGFR2 inhibition significantly decreased the growth-stimulating activity of CAFs for diffuse-type GC cells in normoxia. In contrast, CXCR4 inhibition significantly decreased the growth-stimulating activity of CAFs in hypoxia. SDF1 production by CAFs was increased in hypoxia, while cancer cells did not produce SDF1. HIF1 siRNA significantly decreased both CXCR4 expression by diffuse-type GC cells and SDF1 production by CAFs. These findings suggest that diffuse-type GC cells might switch their driver pathways from FGFR2 signaling to SDF1/CXCR4 axis through HIF1 in hypoxic tumor microenvironments.
2197 related Products with: Diffuse-type gastric cancer cells switch their driver pathways from FGFR2 signaling to SDF1/CXCR4 axis in hypoxic tumor microenvironments.Top 4 types of cancer (co High density (208 cores), Multiple tumor and normal Top 4 types of cancer (co High density (188 cases 2 GI cancer (esophageal, ga Liver cancer tissue array Multiple cancer (12 type) Multiple types of cancer Head & Neck cancer test t Multiple types of kidney Multiple organ cancer and
#26073897 // Save this To Up
CXCR4 pharmacogical inhibition reduces bone and soft tissue metastatic burden by affecting tumor growth and tumorigenic potential in prostate cancer preclinical models.The majority of prostate cancer (Pca) patient morbidity can be attributed to bone metastatic events, which poses a significant clinical obstacle. Therefore, a better understanding of this phenomenon is imperative and might help to develop novel therapeutic strategies. Stromal cell-derived factor 1α (SDF-1α) and its receptor CXCR4 have been implicated as regulators of bone resorption and bone metastatic development, suggesting that agents able to suppress this signaling pathway may be used as pharmacological treatments. In this study we studied if two CXCR4 receptor antagonists, Plerixafor and CTE9908, may affect bone metastatic disease induced by Pca in preclinical experimental models
2096 related Products with: CXCR4 pharmacogical inhibition reduces bone and soft tissue metastatic burden by affecting tumor growth and tumorigenic potential in prostate cancer preclinical models.Prostate cancer tissue ar Prostate cancer tissue ar Prostate cancer tissue ar Prostate cancer tissue ar Bone marrow tumor and adj Prostate cancer test tiss Prostate cancer, adjacent Prostate cancer tissue ar Soft tissue malignant tum Prostate cancer tissue ar Lung cancer tissue array Prostate cancer, hyperpla
#25446376 // Save this To Up
Gemcitabine plus sorafenib versus gemcitabine alone in advanced biliary tract cancer: a double-blind placebo-controlled multicentre phase II AIO study with biomarker and serum programme.Since sorafenib has shown activity in different tumour types and gemcitabine regimens improved the outcome for biliary tract cancer (BTC) patients, we evaluated first-line gemcitabine plus sorafenib in a double-blind phase II study.
2027 related Products with: Gemcitabine plus sorafenib versus gemcitabine alone in advanced biliary tract cancer: a double-blind placebo-controlled multicentre phase II AIO study with biomarker and serum programme.Mid advanced stage pancre Advanced lung cancer and Middle advanced stage ute Advanced colon cancer tis Syringe pump can be contr Mid advanced stage bladde Middle advanced stage bre Advanced breast cancer an Middle advanced stage sto Middle advanced stage eso Advanced kidney cancer ti Mid advanced stage ovary
#24586072 // Save this To Up
The role of SRC1 and SRC2 in steroid-induced SDF1 expression in normal and ectopic endometrium.To compare the expression patterns of steroid receptor coactivators (SRCs) and steroid-induced stromal cell-derived factor 1 (CXCL12 (SDF1)) in normal and ectopic endometrium and to explore the roles of NCOA1 (SRC1) and NCOA2 (SRC2) in the steroid-induced CXCL12 expression in normal and ectopic endometrial stromal cells (ESCs). The NCOA1, NCOA2, NCOA3 (SRC3), and CXCL12 (SDF1)α mRNA levels in normal and ectopic endometrium were analyzed by quantitative real-time PCR. Steroid-induced CXCL12 expression was detected by the ELISA method and the chemotactic activity of conditioned supernatant to monocyte was assessed by the Boyden chamber method before and after the silencing of NCOA1 or NCOA2 with siRNA in normal and ectopic ESCs. The expression of NCOA1 and CXCL12 in ectopic endometrium was significantly greater than that in normal endometrium in the secretory phase. Progesterone (P4) was able to significantly inhibit estradiol (E2)-stimulated CXCL12 expression in normal and ectopic ESCs. The inhibitory rate of P4 in ectopic ESCs at 72 and 96 h was significantly lower than that in normal ESCs. Silencing of NCOA1 but not NCOA2 significantly reduced the E2-induced CXCL12 expression in normal and ectopic ESCs. The ability of P4 to inhibit E2-induced CXCL12 expression and monocyte chemotaxis in normal and ectopic ESCs was significantly attenuated when NCOA2 was silenced. NCOA1 plays a necessary role in E2-induced CXCL12 expression and NCOA2 is required for P4 to inhibit the E2-induced CXCL12 production in normal and ectopic endometrium.
1702 related Products with: The role of SRC1 and SRC2 in steroid-induced SDF1 expression in normal and ectopic endometrium.Endometrium cancer test t Endometrium cancer tissue Endometrium cancer and no Endometrium cancer tissue Colon cancer tissue array Colon cancer tissue array Heart tumor test tissue a Prostate cancer, hyperpla Jurkat Cell Extract (Indu Breast cancer and adjacen Breast cancer test tissue Malignant melanoma test t
#18651648 // Save this To Up
The effect of percutaneous coronary intervention on inflammatory response and endothelial progenitor cell recruitment.Vascular interventions, such as percutaneous coronary interventions (PCI), lead to endothelial damage and cause an inflammatory response. Endothelial progenitor cells (EPC) have been shown to have a prominent role in re-endothelialization and repair following vascular injury. Studies have implicated a role for the chemokine, stromal-cell-derived factor-1 alpha (SDF1-alpha) in the recruitment of circulating EPCs to sites of vascular injury. However, the relationship between the inflammatory response, SDF1-alpha, and EPC levels after PCI is unclear.
2842 related Products with: The effect of percutaneous coronary intervention on inflammatory response and endothelial progenitor cell recruitment.GFP Expressing Human Coro Human Coronary Artery End Human Liver Sinusoidal Mi Human Internal Mammary Ar Human Uterine Microvascul GFP Expressing Human Brai CD31, Endothelial Cell; GFP Expressing Human Aort CD34, Endothelial Cell; GFP Expressing Human Reti Human Ovarian Microvascul CD34, Endothelial Cell;
#17121223 // Save this To Up
[Comparison of immunological profiles between pediatric and adult patients with AIDS in China].To compare the immunological profiles of pediatric and adult patients with AIDS in China.
2237 related Products with: [Comparison of immunological profiles between pediatric and adult patients with AIDS in China].Advanced Airway Intubatio Syringe pump can be contr mTOR Inhibitor, Ku 006379 Goat Anti- GSTM3, (intern AccuPower GreenStar qPCR Rabbit Anti-Insulin Recep Cell Meter™ Fluorimetri Hepatocellular carcinoma SMAD1 & GLI3 Protein Prot Indocyanine Green Interferon alpha-2 antibo Goat Anti-Influenza A Vir
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45 Fax 0032 16 50 90 45
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50 Fax 01 43 25 01 60
52062 Aachen Deutschland
Tel 0241 40 08 90 86 Fax 0241 55 91 05 36
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
Schweiz Züri +41435006251
Česká republika Praha +420246019719
Ireland Dublin +35316526556
Norge Oslo +4721031366
Finland Helsset +358942419041
Sverige Stockholm +46852503438
Ελλάς Αθήνα +302111768494
Magyarország Budapest +3619980547
GENTAUR Poland Sp. z o.o.
ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
Tel 058 710 33 44
Fax 058 710 33 48
GENTAUR Nederland BV
5521 DG Eersel Nederland
Tel 0208-080893 Fax 0497-517897
Piazza Giacomo Matteotti, 6, 24122 Bergamo
Tel 02 36 00 65 93 Fax 02 36 00 65 94
53 Iskar Str. 1191 Kokalyane, Sofia