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           Search results for: Human Vascular Endothelial Growth Factor-121 VEGF-121   

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#27955747   2016/12/13 Save this To Up

Recombinant expression and purification of functional vascular endothelial growth factor-121 in the baculovirus expression system.

To express human vascular endothelial growth factor121 (VEGF121) in insect cells.

1858 related Products with: Recombinant expression and purification of functional vascular endothelial growth factor-121 in the baculovirus expression system.

Human Vascular Endothelia Recombinant Human Vascula Human Endocrine Gland Vas Human Vascular Endothelia Mouse Vascular Endothelia Mouse Vascular Endothelia Rat Vascular Endothelial Mouse Vascular Endothelia Recombinant Mn SOD (Human Fibroblast Growth Factor Fibroblast Growth Factor Growth Differentiation Fa

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#16150930   2005/11/18 Save this To Up

Vascular targeting of ocular neovascularization with a vascular endothelial growth factor121/gelonin chimeric protein.

Tumors provide an extremely abnormal microenvironment that stimulates neovascularization from surrounding vessels and causes altered gene expression within vascular cells. Up-regulation of vascular endothelial growth factor (VEGF) receptors has allowed selective destruction of tumor vessels by administration of a chimeric protein consisting of VEGF121 coupled to the toxin gelonin (VEGF/rGel). We sought to determine whether there is sufficient up-regulation of VEGF receptors in endothelial cells participating in ocular neovascularization to permit a similar strategy. After intravenous injection of 45 mg/kg VEGF/rGel, but not uncoupled recombinant gelonin (rGel), there was immunofluorescent staining for rGel within choroidal neovascularization in mice and regression of the neovascularization occurred, demonstrating successful vascular targeting via the systemic circulation. Intraocular injection of 5 ng of VEGF/rGel also caused significant regression of choroidal neovascularization and regression of retinal neovascularization in two models, transgenic mice with expression of VEGF in photoreceptors and mice with ischemic retinopathy, whereas injection of 5 ng of rGel had no effect. These data suggest that the strategy of vascular targeting can be applied to nonmalignant neovascular diseases and could serve as the basis of a new treatment to reduce established ocular neovascularization.

2603 related Products with: Vascular targeting of ocular neovascularization with a vascular endothelial growth factor121/gelonin chimeric protein.

Human Endocrine Gland Vas Human Vascular Endothelia Human Vascular Endothelia Mouse Vascular Endothelia Mouse Vascular Endothelia Rat Vascular Endothelial Mouse Vascular Endothelia Recombinant Human Vascula Human vascular cell adhes Human soluble vascular ce Rat monoclonal anti mouse Rat monoclonal anti mouse

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#10949658   2000/12/14 Save this To Up

Insights into the vasodilation of rat retinal vessels evoked by vascular endothelial growth factor121 (VEGF121).


1567 related Products with: Insights into the vasodilation of rat retinal vessels evoked by vascular endothelial growth factor121 (VEGF121).

Rat Vascular Endothelial Human Endocrine Gland Vas Human Vascular Endothelia Human Vascular Endothelia Mouse Vascular Endothelia Mouse Vascular Endothelia Mouse Vascular Endothelia Recombinant Human Vascula Rat growth hormone releas Rat transforming growth f Rat Insulin-like Growth F Rat Fibroblast Growth Fac

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