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           Search results for: Human Vascular Endothelial Growth Factor-121 VEGF-121   

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Recombinant expression and purification of functional vascular endothelial growth factor-121 in the baculovirus expression system.

To express human vascular endothelial growth factor121 (VEGF121) in insect cells.

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Vascular targeting of ocular neovascularization with a vascular endothelial growth factor121/gelonin chimeric protein.

Tumors provide an extremely abnormal microenvironment that stimulates neovascularization from surrounding vessels and causes altered gene expression within vascular cells. Up-regulation of vascular endothelial growth factor (VEGF) receptors has allowed selective destruction of tumor vessels by administration of a chimeric protein consisting of VEGF121 coupled to the toxin gelonin (VEGF/rGel). We sought to determine whether there is sufficient up-regulation of VEGF receptors in endothelial cells participating in ocular neovascularization to permit a similar strategy. After intravenous injection of 45 mg/kg VEGF/rGel, but not uncoupled recombinant gelonin (rGel), there was immunofluorescent staining for rGel within choroidal neovascularization in mice and regression of the neovascularization occurred, demonstrating successful vascular targeting via the systemic circulation. Intraocular injection of 5 ng of VEGF/rGel also caused significant regression of choroidal neovascularization and regression of retinal neovascularization in two models, transgenic mice with expression of VEGF in photoreceptors and mice with ischemic retinopathy, whereas injection of 5 ng of rGel had no effect. These data suggest that the strategy of vascular targeting can be applied to nonmalignant neovascular diseases and could serve as the basis of a new treatment to reduce established ocular neovascularization.

1498 related Products with: Vascular targeting of ocular neovascularization with a vascular endothelial growth factor121/gelonin chimeric protein.

Rat Vascular Endothelial Human Endocrine Gland Vas Mouse Vascular Endothelia Recombinant Human Vascula Human Vascular Endothelia Human Vascular Endothelia Mouse Vascular Endothelia Mouse Vascular Endothelia Rat monoclonal anti mouse Rat monoclonal anti mouse Human soluble vascular ce Rat monoclonal anti mouse

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