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#29476313   // Save this To Up

Sensitivity to Peer Evaluation and Its Genetic and Environmental Determinants: Findings from a Population-Based Twin Study.

Adolescents and young adults are highly focused on peer evaluation, but little is known about sources of their differential sensitivity. We examined to what extent sensitivity to peer evaluation is influenced by interacting environmental and genetic factors. A sample of 354 healthy adolescent twin pairs (n = 708) took part in a structured, laboratory task in which they were exposed to peer evaluation. The proportion of the variance in sensitivity to peer evaluation due to genetic and environmental factors was estimated, as was the association with specific a priori environmental risk factors. Differences in sensitivity to peer evaluation between adolescents were explained mainly by non-shared environmental influences. The results on shared environmental influences were not conclusive. No impact of latent genetic factors or gene-environment interactions was found. Adolescents with lower self-rated positions on the social ladder or who reported to have been bullied more severely showed significantly stronger responses to peer evaluation. Not genes, but subjective social status and past experience of being bullied seem to impact sensitivity to peer evaluation. This suggests that altered response to peer evaluation is the outcome of cumulative sensitization to social interactions.

1788 related Products with: Sensitivity to Peer Evaluation and Its Genetic and Environmental Determinants: Findings from a Population-Based Twin Study.

Androgen Receptor (Phosph Androgen Receptor (Phosph Rabbit Anti-Human Androge Rabbit Anti-Human Androge Androgen Receptor (Ab 650 AZD-3514 Mechanisms: Andr 17β-Acetoxy-2α-bromo-5 (5α,16β)-N-Acetyl-16-[2 (5α,16β)-N-Acetyl-16-ac 5α-N-Acetyl-2'H-androst- 5α-N-Acetyl-2'H-androst- 3-O-Acetyl 5,14-Androstad

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Remapping of the stripe rust resistance gene Yr10 in common wheat.

Yr10 is an important gene to control wheat stripe rust, and the search for Yr10 needs to be continued. Wheat stripe rust or yellow rust is a devastating fungal disease caused by Puccinia striiformis f. sp. tritici (Pst). Host disease resistance offers a primary source for controlling wheat stripe rust. The stripe rust resistance gene Yr10 confers the race-specific resistance to most tested Pst races in China including CYR29. Early studies proposed that Yr10 was a nucleotide-binding site, leucine-rich repeat gene archived as GenBank accession AF149112 (hereafter designated the Yr10 candidate gene or Yr10). In this study, we revealed that 15 Chinese wheat cultivars positive for Yr10are susceptible to CYR29. We then expressed the Yr10cDNA in the common wheat 'Bobwhite'. The Yr10-cDNA positive transgenic plants were also susceptible to CYR29. Thus, it is highly unlikely that Yr10corresponds to the Yr10 resistance gene. Using the Yr10 donor 'Moro' and the Pst-susceptible wheat 'Huixianhong', we generated two Fpopulations that displayed a single Mendelian segregation on the Yr10 gene, and used them to remap the Yr10 gene. Six markers were placed in the Yr10 region, with the Yr10gene now mapping about 1.2-cM proximal to the Yr10 locus and the Xsdauw79 marker is completely linked to the Yr10 locus. Apparently, the Yr10 gene has not yet been identified. Fine mapping and positional cloning of Yr10 is important for gene pyramiding for stripe rust resistance in wheat.

1163 related Products with: Remapping of the stripe rust resistance gene Yr10 in common wheat.

DNA (cytosine 5) methyltr Human Epstein-Barr Virus Mouse Epstein-Barr Virus Rat TGF-beta-inducible ea Rat TGF-beta-inducible ea Thermal Shaker with cooli FDA Standard Frozen Tissu FDA Standard Frozen Tissu FDA Standard Frozen Tissu FDA Standard Frozen Tissu FDA Standard Frozen Tissu FDA Standard Frozen Tissu

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Impact of the AIF Recording Method on Kinetic Parameters in Small Animal PET.

The goal of this study was to validate the use of a magnetic resonance-compatible blood sampler (BS) with the detector system based on lutetium oxyorthosilicate scintillator and avalanche photodiodes for small animal positron emission tomography (PET).Five rats underwent a 60 minF-FDG study. For each animal, the arterial input function (AIF) was derived from the BS recording, from manual blood sampling (MS) and from the PET image. These AIFs were used for kinetic modelling of the striatum using the two tissue irreversible compartment model. The MS-based technique with a dispersion correction served as a reference approach and the kinetic parameters (KPs) estimated with the BS- and the image-derived (ID) AIFs were compared to the reference values. Additionally, the effect of applying a population-based plasma versus whole blood activity ratio (p/wb) and the dispersion correction were assessed.The K1, k2 and k3 values estimated with the reference approach were 0.174±0.037 mL/min/cm, 0.342±0.080 1/min and 0.048±0.009 1/min, respectively. The corresponding parameters obtained with the BS- and ID-AIFs deviated from these values by 0.6-18.8 % and 16.7-47.9 %, respectively. To compensate for the error in the BS-based technique, data from one blood sample manually collected at the end of the experiment were combined with the data from the first 10 min of the BS recording. This approach allowed reducing the deviation in the KPs to 1.8-6.3 %. Using the p/wb ratio led to the 1.7-8.3 % difference from the reference parameters. The sensitivity of the BS was 23 %, the energy resolution for the 511 keV photo peak was 19 % and the timing resolution was 11.2 ns.Online recording of the blood activity level with the BS allows precise measurement of the AIF, without losing the blood volume. Combining the BS data with one manually collected blood sample is the most accurate approach for the data analysis. The high sensitivity of the device may allow applying lower radioactivity doses.

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Helsmoortel-Van der Aa Syndrome as emerging clinical diagnosis in intellectually disabled children with autistic traits and ocular involvement.

A recent syndromic condition with craniofacial dysmorphisms, comprising congenital ocular defect and neurodevelopmental delay named Helsmoortel-Van der Aa Syndrome (HVDAS) (OMIM#615873), has been described and molecularly defined, identifying pathogenic mutations in the ADNP gene (OMIM#611386) as biological cause. We report on two children, displaying intellectual disability (ID) and peculiar congenital eyes anomalies, both carrying a de novo nonsense mutation in the ADNP gene. The review of present and literature reports, suggests that the diagnosis of HVDAS should be suspected in patients with ID accompanied by behavioral features in the Autism Spectrum Disorder and distinctive craniofacial phenotype. Among dysmorphisms due to malformation of the periorbital region, ptosis appears to be particularly recurrent in HVDAS. Furthermore, the present patients could support the inclusion of the HVDAS associated with specific mutations clustering within a small ADNP genomic region among clinical conditions reminiscent of the blepharophimosis/mental retardation syndromes (BMRS).

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Human Platelet Derived Gr EMAP-II Inhibitor Z-ASTD- EMAP-II Inhibitor Z-ASTD- EMAP II Inhibitor Z ASTD EMAP II Inhibitor Z ASTD Granzyme B Inhibitor Z-AA Granzyme B Inhibitor Z-AA Granzyme B Inhibitor Z AA Granzyme B Inhibitor Z AA Amplite™ Fluorimetric H Amplite™ Intracellular Amplite™ Fluorimetric P

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Present status ofCs in seawaters of the Lombok Strait and the Flores Sea at the Indonesia Through Flow (ITF) following the Fukushima accident.

Due to thermocline and surface water from the western equatorial Pacific Ocean, which are transported to the Indian Ocean, Indonesian marine waters play an important role in the global ocean circulation. The objective of this study was to assess the spatial distribution ofCs in the Lombok Strait as part of a national monitoring program concerning the possible impacts of radionuclides released as a result of the Fukushima accident. Sampling was conducted in the Flores sea and Lombok Strait on 15 to 24 November 2013. Measurements for the Lombok strait showed thatCs concentrations at surface layer, thermocline layer and 1000m depth were 0.27Bqm; 0.42Bqmand

1301 related Products with: Present status ofCs in seawaters of the Lombok Strait and the Flores Sea at the Indonesia Through Flow (ITF) following the Fukushima accident.

Thermal Shaker with cooli FDA Standard Frozen Tissu FDA Standard Frozen Tissu FDA Standard Frozen Tissu FDA Standard Frozen Tissu FDA Standard Frozen Tissu FDA Standard Frozen Tissu Multiple organ tumor tiss MultiGene Gradient therm BACTERIOLOGY BACTEROIDES TCP-1 theta antibody Sour Recombinant Thermostable

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Environmental DNA metabarcoding of benthic bacterial communities indicates the benthic footprint of salmon aquaculture.

We evaluated benthic bacterial communities as bioindicators in environmental impact assessments of salmon aquaculture, a rapidly growing sector of seafood industry. Sediment samples (n=72) were collected from below salmon cages towards distant reference sites. Bacterial community profiles inferred from DNA metabarcodes were compared to reference data from standard macrofauna biomonitoring surveys of the same samples. Deltaproteobacteria were predominant in immediate vicinity of the salmon cages. Along the transect, significant shifts in bacterial community structures were observed with Gammaproteobacteria dominating the less-impacted sites. Alpha- and beta-diversity measures of bacterial communities correlated significantly with macrofauna diversity metrics and with five ecological status indices. Benthic bacterial communities mirror the reaction of macrofauna bioindicators to environmental disturbances caused by salmon farming. The implementation of bacterial eDNA metabarcoding in future Strategic Framework Directives is an alternative cost-effective high-throughput biomonitoring solution, providing a basis for management strategies in a matter of days rather than months.

1417 related Products with: Environmental DNA metabarcoding of benthic bacterial communities indicates the benthic footprint of salmon aquaculture.

Native Bacterial DNase Pr Native Bacterial DNase Pr Native Bacterial DNase Pr Single Strand DNA Ligase, Single Strand DNA Ligase, Salmon Sperm DNA Salmonella Real Time PCR Salmonella Real Time PCR Salmonella Real Time PCR pCAMBIA0105.1R Vector, (G Ofloxacin CAS Number [824 Pfu DNA Polymerase protei

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Strong cation exchange-reversed phase liquid chromatography-capillary zone electrophoresis-tandem mass spectrometry platform with high peak capacity for deep bottom-up proteomics.

Two-dimensional (2D) liquid chromatography (LC)-tandem mass spectrometry (MS/MS) are typically employed for deep bottom-up proteomics, and the state-of-the-art 2D-LC-MS/MS has approached over 8000 protein identifications (IDs) from mammalian cell lines or tissues in 1-3 days of mass spectrometer time. Capillary zone electrophoresis (CZE)-MS/MS has been suggested as an alternative to LC-MS/MS for bottom-up proteomics. CZE-MS/MS and LC-MS/MS are complementary in protein/peptide ID from complex proteome digests because CZE and LC are orthogonal for peptide separation. In addition, the migration time of peptides from CZE-MS can be predicted accurately, which is invaluable for evaluating the confidence of peptide ID from the database search and even guiding the database search. However, the number of protein IDs from complex proteomes using CZE-MS/MS is still much lower than the state of the art using 2D-LC-MS/MS. In this work, for the first time, we established a strong cation exchange (SCX)-reversed phase LC (RPLC)-CZE-MS/MS platform for deep bottom-up proteomics. The platform identified around 8200 protein groups and 65,000 unique peptides from a mouse brain proteome digest in 70 h. The data represents the largest bottom-up proteomics dataset using CZE-MS/MS and provides a valuable resource for further improving the tool for prediction of peptide migration time in CZE. The peak capacity of the orthogonal SCX-RPLC-CZE platform was estimated to be around 7000. SCX-RPLC-CZE-MS/MS produced comparable numbers of protein and peptide IDs with 2D-LC-MS/MS (8200 vs. 8900 protein groups, 65,000 vs. 70,000 unique peptides) from the mouse brain proteome digest using comparable instrument time. This is the first time that CZE-MS/MS showed its capability to approach comparable performance to the state-of-the-art 2D-LC-MS/MS for deep proteomic sequencing. SCX-RPLC-CZE-MS/MS and 2D-LC-MS/MS showed good complementarity in protein and peptide IDs and combining those two methods improved the number of protein group and unique peptide IDs by nearly 10% and over 40%, respectively, compared with 2D-LC-MS/MS alone.

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uPAR Blocking Peptide;App Protein A (Liquid form) Protein A (Liquid form) Protein A (Liquid form) Protein A (Liquid form) Rabbit Anti Human uPA Aff Rabbit Anti Human uPA Aff Rabbit Anti Mouse uPA Aff Rabbit Anti Mouse uPA Aff 8 Octadecyloxypyrene 1,3, Syringe pump can be contr Cellufine Formyl , 50 ml

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What is an ORCID iD and Why Would You Want One?


1784 related Products with: What is an ORCID iD and Why Would You Want One?

Mouse Anti-Human CD34 Tar B-Phycoerythrin antibody 2-Amino Benzimidazole Su 2-Amino Benzimidazole Su EZH2 KMT6 antibody Isoty Interleukin-34 IL34 (N-t Interleukin-34 IL34 anti CRC3 CD3 (bispecific) Cl 2,3 dinor 6 keto Prostag ROR1 Clone '1B4 antibody RBPMS HERMES Clone '1C12 Glucokinase, islet isofor

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Zwitterionic cocrystal of diclofenac and l-proline: Structure determination, solubility, kinetics of cocrystallization, and stability study.


2867 related Products with: Zwitterionic cocrystal of diclofenac and l-proline: Structure determination, solubility, kinetics of cocrystallization, and stability study.

Androgen Receptor (Phosph Androgen Receptor (Phosph Rabbit Anti-Human Androge Rabbit Anti-Human Androge Androgen Receptor (Ab 650 SMCC Plus™ *Enhanced wa AZD-3514 Mechanisms: Andr 17β-Acetoxy-2α-bromo-5 (5α,16β)-N-Acetyl-16-[2 (5α,16β)-N-Acetyl-16-ac 5α-N-Acetyl-2'H-androst- 5α-N-Acetyl-2'H-androst-

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Comparative genomic analysis of Rickettsia rickettsii for the identification of drug and vaccine targets: tolC as a proposed candidate for case study.

Antibiotic resistance is increasing rapidly in pathogenic organisms, creating more complications for treatment of diseases. Rocky Mountain spotted fever (RMSF) is a neglected tropical disease in humans caused by Rickettsia rickettsii for which no effective therapeutic is available. Subtractive genomics methods facilitate the characterization of non-homologous essential proteins that could be targeted for the discovery of potential therapeutic compounds against R. rickettsii to combat RMSF. Present study followed an in-silico based methodology, involving scanning and filtering the complete proteome of Rickettsia rickettsii by using several prioritization parameters in the search of potential candidates for drug development. Further the putative targets were subjected to series of molecular dockings with ligands obtained from PDB ligand database to identify suitable potential inhibitors. The comparative genomic analysis revealed 606 non-homologous proteins and 233 essential non-homologous proteins of R. rickettsii. The metabolic pathway analysis predicted 120 proteins as putative drug targets, out of which 56 proteins were found to be associated with metabolic pathways unique to the bacteria and further subcellular localization analysis revealed that 9 proteins as potential drug targets which are secretion proteins, involved in peptidoglycan biosynthesis, folate biosynthesis and bacterial secretion system. As secretion proteins are more feasible as vaccine candidates, we have selected a most potential target i.e. TolC, an outer membrane efflux protein that belongs to type I secretion system and has major role in pathogen survival as well as MDR persistence. So for case study, we have modelled the three dimensional structure of tolC (tunnel protein). The model was further subjected to virtual screening and in-silico docking. The study identified three potential inhibitors having PDB Id 19V, 6Q8 and 39H. Further we have suggested that the above study would be most important while considering the selection of candidate targets and drug or vaccine designing against R. rickettsii.

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Glucose Assay With the La Cultrex In Vitro Angiogen Breast invasive ductal ca Endothelial Tube Formatio QuantiChrom™ Formaldehy QuantiChrom™ Formaldehy Formate Assay Kit Multiple lung carcinoma ( Lymphoma array, together MarkerGeneTM Fluorescent MarkerGene™ LysoLive™ MOUSE ANTI BOVINE ROTAVIR

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