Search results for: IgGIL4 RECEPTOR
#38648673 
2024/04/22
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Resistance training and cardiometabolic risk in women with metabolically healthy and unhealthy obesity.
DEve-Julie Tremblay, Paul Peyrel, Antony Karelis, Rémi Rabasa-Lhoret, André Tchernof, Denis R Joanisse, Pascale Mauriège
2775 related Products with: Resistance training and cardiometabolic risk in women with metabolically healthy and unhealthy obesity.
100ul200ul2.5 mg25 mg1000 tests10 mg10 mg50 ug 100 mg1,000 tests200ug1 mg
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#38648538 2024/04/22
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Bone Remodeling and Bone Structural Genes in Legg-Calvé-Perthes Disease: The rs2073618 and rs1800795 Are Associated with High Risk in Mexican Patients.
Legg-Calve-Perthes disease (LCPD) is an idiopathic avascular necrosis of the pediatric femoral head. Bone remodeling and bone structural genes have the potential to contribute to the progression of LCPD when there is disequilibrium between bone resorption and bone formation. A case-control study was performed to search for associations of several common polymorphisms in the genes Receptor Activator for Nuclear Factor κappa B (), Receptor Activator for Nuclear Factor κappa B Ligand (), osteoprotegerin (), interleukin ()-, and type 1 collagen () with LCPD susceptibility in Mexican children. A total of 23 children with LCPD and 46 healthy controls were genotyped for seven polymorphisms (rs3018362, rs12585014, rs2073618, rs1800795, rs1800796, rs1800012, and rs2586498) in the , , , , and genes by real-time polymerase chain reaction with TaqMan probes. The variant allele (C) of rs1800795 was associated with increased risk of LCPD (odds ratio [OR]: 3.8, 95% confidence interval [CI]: [1.08-13.54], = 0.033), adjusting data by body mass index (BMI) and coagulation factor V (FV), the association with increased risk remained (OR: 4.9, 95% CI: [1.14-21.04], = 0.025). The polymorphism rs2073618, specifically GC-GG carriers, was associated with a more than fourfold increased risk of developing LCPD (OR: 4.34, 95% CI: [1.04-18.12], = 0.033) when data were adjusted by BMI-FV. There was no significant association between rs3018362, rs12585014, rs1800796, rs1800012, and rs2586498 polymorphisms and LCPD in a sample of Mexican children. The rs1800975 and rs2037618 polymorphisms in the and genes, respectively, are informative markers of increased risk of LCPD in Mexican children.Blanca Lucía Cruz-Ortíz, Edgar Hernández-Zamora, Elba Reyes-Maldonado, Armando Odiseo Rodríguez-Olivas, Julieta Rubio-Lightbourn, Celeste O Martínez-Ramírez, Clementina Castro-Hernández, Ruth Lezama-Palacios, Leonora Casas-Avila
1531 related Products with: Bone Remodeling and Bone Structural Genes in Legg-Calvé-Perthes Disease: The rs2073618 and rs1800795 Are Associated with High Risk in Mexican Patients.
900 testscase4 Membranes/Box2 Pieces/Box
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#38648537 2024/04/22
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Molecular docking, MMGBSA, and ADMET studies of phytoconstituents of on multiple breast cancer targets.
is one of the most common medicinal plants in every community in Nigeria. This plant has been presumed to be useful in the management of diseases including breast cancer, which is one the commonest cancers affecting women globally. Hence, this study aimed to computationally investigate the phytochemicals present in by elucidate their binding dynamics against five selected molecular targets of breast cancer and predict their pharmacokinetics properties. Molecular docking, MMGBSA calculation and ADMET prediction were used. The results showed that isovitexin has the highest binding affinity of -9.11 kcal/mol and -9.80 kcal/mol for Human Epidermal Growth Factor Receptor 2 (HER2) and Epidermal Growth Factor Receptor (EGFR) respectively. Rosmarinic acid has the highest binding affinity of -12.15 kcal/mol for Phosphatidylinositol 3-kinase (PI3K), Nepetoidin A has the highest binding affinity of -9.14 kcal/mol for oestrogen receptor (ER), and Vitexin has the highest binding affinity of -12.90 kcal/mol for Progesterone receptor (PR). MMGBSA provided total binding energy that confirmed the stability of the complexes under physiological conditions. The ADMET profiles showed that top phytochemicals identified would be safe for oral administration with no hepatoxicity. Overall, this study identified isovitexin, vitexin, rosmarinic acid, nepetoidin A and luteolin among others, as compounds that exhibit strong anti-cancer properties against breast cancer cells.Basiru Olaitan Ajiboye, Toluwase Hezekiah Fatoki, Precious Ayorinde Akinnusi, Olawale Rasaq Ajuwon, Babatunji Emmanuel Oyinloye, Temitope Olawale Jeje, Olutunmise Victoria Owolabi, Oluwatosin O Ogedengbe, Claudia Genovese
2814 related Products with: Molecular docking, MMGBSA, and ADMET studies of phytoconstituents of on multiple breast cancer targets.
100ul
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#38648498 2024/04/22
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Molecular Assessment of Pro-Adipogenic Effects for Common-Use Contraceptives and their Mixtures.
Hormonal contraceptives are widely prescribed due to their effectiveness and convenience and have become an integral part of family planning strategies worldwide. In the US, ∼65% of reproductive aged women are estimated to be using contraceptive options, with ∼33% using one or a combination of hormonal contraceptives. While these methods have undeniably contributed to improved reproductive health, recent studies have raised concerns regarding their potential impact on metabolic health. Despite widespread anecdotal reports, epidemiological research has been mixed as to whether hormonal contraceptives contribute to metabolic health effects. As such, the goals of this study were to assess the adipogenic activity of common hormonal contraceptive chemicals and their mixtures. Five different models of adipogenesis were utilized to provide a rigorous assessment of metabolism disrupting effects. Interestingly, every individual contraceptive (both estrogens and progestins) and each mixture promoted significant adipogenesis (e.g., triglyceride accumulation and/or pre-adipocyte proliferation). These effects appeared to be mediated in part through estrogen receptor signaling, particularly for the contraceptive mixtures, as co-treatment with fulvestrant acted to inhibit contraceptive-mediated pro-adipogenic effects on triglyceride accumulation. In conclusion, this research provides valuable insights into the complex interactions between hormonal contraceptives and adipocyte development. The results suggest that both progestins and estrogens within these contraceptives can influence adipogenesis, and the specific effects may vary based on the receptor activation profiles. Further research is warranted to establish translation of these findings to in vivo models and to further assess causal mechanisms underlying these effects.Yu-Ting Tiffany Chiang, Christopher D Kassotis
2269 related Products with: Molecular Assessment of Pro-Adipogenic Effects for Common-Use Contraceptives and their Mixtures.
2x5L 1L20 ug10 mg 6 ml Ready-to-use 1000 ml 25 mg 1 G50 ug 100 ml
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#38648487 2024/04/22
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Single-chain fluorescent integrators for mapping G-protein-coupled receptor agonists.
G protein-coupled receptors (GPCRs) transduce the effects of many neuromodulators including dopamine, serotonin, epinephrine, acetylcholine, and opioids. The localization of synthetic or endogenous GPCR agonists impacts their action on specific neuronal pathways. In this paper, we show a series of single-protein chain integrator sensors that are highly modular and could potentially be used to determine GPCR agonist localization across the brain. We previously engineered integrator sensors for the mu- and kappa-opioid receptor agonists called M- and K-Single-chain Protein-based Opioid Transmission Indicator Tool (SPOTIT), respectively. Here, we engineered red versions of the SPOTIT sensors for multiplexed imaging of GPCR agonists. We also modified SPOTIT to create an integrator sensor design platform called SPOTIT for all GPCRs (SPOTall). We used the SPOTall platform to engineer sensors for the beta 2-adrenergic receptor (B2AR), the dopamine receptor D1, and the cholinergic receptor muscarinic 2 agonists. Finally, we demonstrated the application of M-SPOTIT and B2AR-SPOTall in detecting exogenously administered morphine, isoproterenol, and epinephrine in the mouse brain via locally injected viruses. The SPOTIT and SPOTall sensor design platform has the potential for unbiased agonist detection of many synthetic and endogenous neuromodulators across the brain.Kayla Kroning, Noam Gannot, Xingyu Li, Aubrey Putansu, Guanwei Zhou, Jennifer Sescil, Jiaqi Shen, Avery Wilson, Hailey Fiel, Peng Li, Wenjing Wang
2482 related Products with: Single-chain fluorescent integrators for mapping G-protein-coupled receptor agonists.
50ug50ug50ug50ug50ug50ug50ug50ug100ul50ug 100ul10
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#38648483 2024/04/22
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Mapping seasonal migration in a songbird hybrid zone -- heritability, genetic correlations, and genomic patterns linked to speciation.
Seasonal migration is a widespread behavior relevant for adaptation and speciation, yet knowledge of its genetic basis is limited. We leveraged advances in tracking and sequencing technologies to bridge this gap in a well-characterized hybrid zone between songbirds that differ in migratory behavior. Migration requires the coordinated action of many traits, including orientation, timing, and wing morphology. We used genetic mapping to show these traits are highly heritable and genetically correlated, explaining how migration has evolved so rapidly in the past and suggesting future responses to climate change may be possible. Many of these traits mapped to the same genomic regions and small structural variants indicating the same, or tightly linked, genes underlie them. Analyses integrating transcriptomic data indicate cholinergic receptors could control multiple traits. Furthermore, analyses integrating genomic differentiation further suggested genes underlying migratory traits help maintain reproductive isolation in this hybrid zone.Hannah C Justen, Wendy E Easton, Kira E Delmore
1409 related Products with: Mapping seasonal migration in a songbird hybrid zone -- heritability, genetic correlations, and genomic patterns linked to speciation.
25 100 1 kit100 μg1 mg1 kit300 units
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#38648460 2024/04/20
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Differences of ocular oscillations and neuro-retinal structures in patients with nystagmus caused by GPR143 and FRMD7 gene variants.
Mutations of G protein-coupled receptor 143 (GPR143) and FERM domain containing 7 (FRMD7) may result in congenital nystagmus (CN) in the first 6 months of life. We aimed to compare the differences in ocular oscillations between patients with these two gene mutations as well as the functional and structural changes in their retinas and visual pathways.Lijuan Huang, Biru Xu, Ningdong Li
2839 related Products with: Differences of ocular oscillations and neuro-retinal structures in patients with nystagmus caused by GPR143 and FRMD7 gene variants.
1 mg1,000 tests200ug25 mg50 ug 1000 tests100ug1 ml100ug 5 G5mg
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