Search results for: IgGMitotic cells
#38648627 
2024/04/22
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Anterior Vitreous Objective Assessment in Uveitis: An Anterior Segment Swept Source Optical Coherence Tomography Study.
To assess inflammatory changes in the anterior vitreous (AV) using a swept source anterior segment optical coherence tomography (SS-ASOCT) and to correlate them with uveitis features and clinical grading of intraocular inflammation.Alessandro Invernizzi, Chiara Zaffalon, Priscilla Manni, Federico Zicarelli, Domenico Chisari, Chantal Adani, Valentina Mastrofilippo, Elena Bolletta, Fabrizio Gozzi, Luca De Simone, Giovanni Staurenghi, Luca Cimino
2751 related Products with: Anterior Vitreous Objective Assessment in Uveitis: An Anterior Segment Swept Source Optical Coherence Tomography Study.
100ul 100ul 100ul 100ul 100ul 100ul 100ul 100ul 100ul 100ul50ul 100ul
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#38648537 2024/04/22
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Molecular docking, MMGBSA, and ADMET studies of phytoconstituents of on multiple breast cancer targets.
is one of the most common medicinal plants in every community in Nigeria. This plant has been presumed to be useful in the management of diseases including breast cancer, which is one the commonest cancers affecting women globally. Hence, this study aimed to computationally investigate the phytochemicals present in by elucidate their binding dynamics against five selected molecular targets of breast cancer and predict their pharmacokinetics properties. Molecular docking, MMGBSA calculation and ADMET prediction were used. The results showed that isovitexin has the highest binding affinity of -9.11 kcal/mol and -9.80 kcal/mol for Human Epidermal Growth Factor Receptor 2 (HER2) and Epidermal Growth Factor Receptor (EGFR) respectively. Rosmarinic acid has the highest binding affinity of -12.15 kcal/mol for Phosphatidylinositol 3-kinase (PI3K), Nepetoidin A has the highest binding affinity of -9.14 kcal/mol for oestrogen receptor (ER), and Vitexin has the highest binding affinity of -12.90 kcal/mol for Progesterone receptor (PR). MMGBSA provided total binding energy that confirmed the stability of the complexes under physiological conditions. The ADMET profiles showed that top phytochemicals identified would be safe for oral administration with no hepatoxicity. Overall, this study identified isovitexin, vitexin, rosmarinic acid, nepetoidin A and luteolin among others, as compounds that exhibit strong anti-cancer properties against breast cancer cells.Basiru Olaitan Ajiboye, Toluwase Hezekiah Fatoki, Precious Ayorinde Akinnusi, Olawale Rasaq Ajuwon, Babatunji Emmanuel Oyinloye, Temitope Olawale Jeje, Olutunmise Victoria Owolabi, Oluwatosin O Ogedengbe, Claudia Genovese
1762 related Products with: Molecular docking, MMGBSA, and ADMET studies of phytoconstituents of on multiple breast cancer targets.
100ul
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#38648505 2024/04/22
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Calcineurin-NFAT signaling controls neutrophils´ ability of chemoattraction upon fungal infection.
Calcineurin - nuclear factor of activated T-cell (CN-NFAT) inhibitors are widely clinically used drugs for immunosuppression but besides their required T-cell response inhibition, they also undesirably affect innate immune cells. Disruption of innate immune cell function can explain the observed susceptibility of CN-NFAT inhibitors-treated patients to opportunistic fungal infections. Neutrophils play an essential role in innate immunity as a defense against pathogens, however, the effect of CN-NFAT inhibitors on neutrophil function was poorly described. Thus, we tested the response of human neutrophils to opportunistic fungal pathogens, namely Candida albicans and Aspergillus fumigatus in the presence of CN-NFAT inhibitors. Here, we report that the NFAT pathway members were expressed in neutrophils and mediated part of the neutrophil response to pathogens. Upon pathogen exposure, neutrophils underwent profound transcriptomic changes with subsequent production of effector molecules. Importantly, genes and proteins involved in the regulation of the immune response and chemotaxis, including the chemokines CCL2, CCL3, and CCL4 were significantly upregulated. The presence of CN-NFAT inhibitors attenuated the expression of these chemokines and impaired the ability of neutrophils to chemoattract other immune cells. Our results amend knowledge about the impact of CN-NFAT inhibition in human neutrophils.O Vymazal, I Papatheodorou, I Andrejčinová, V Bosáková, G Vascelli, K Bendíčková, T Zelante, M Hortová-Kohoutková, J Frič
2897 related Products with: Calcineurin-NFAT signaling controls neutrophils´ ability of chemoattraction upon fungal infection.
25 TESTS250ul2 Pieces/Box1250ul16 Arrays/Slide11 inhibitors1.5x10(6) cells0.5 mg
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#38648494 //
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Repair and regeneration of the alveolar epithelium in lung injury.
Considerable progress has been made in understanding the function of alveolar epithelial cells in a quiescent state and regeneration mechanism after lung injury. Lung injury occurs commonly from severe viral and bacterial infections, inhalation lung injury, and indirect injury sepsis. A series of pathological mechanisms caused by excessive injury, such as apoptosis, autophagy, senescence, and ferroptosis, have been studied. Recovery from lung injury requires the integrity of the alveolar epithelial cell barrier and the realization of gas exchange function. Regeneration mechanisms include the participation of epithelial progenitor cells and various niche cells involving several signaling pathways and proteins. While alveoli are damaged, alveolar type II (AT2) cells proliferate and differentiate into alveolar type I (AT1) cells to repair the damaged alveolar epithelial layer. Alveolar epithelial cells are surrounded by various cells, such as fibroblasts, endothelial cells, and various immune cells, which affect the proliferation and differentiation of AT2 cells through paracrine during alveolar regeneration. Besides, airway epithelial cells also contribute to the repair and regeneration process of alveolar epithelium. In this review, we mainly discuss the participation of epithelial progenitor cells and various niche cells involving several signaling pathways and transcription factors.Yaxuan Wang, Lan Wang, Shuaichen Ma, Lianhui Cheng, Guoying Yu
2740 related Products with: Repair and regeneration of the alveolar epithelium in lung injury.
96T
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#38648485 2024/04/22
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PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells.
TCasey D S Katerndahl, Olivia R S Rogers, Ryan B Day, Ziheng Xu, Nichole M Helton, Sai Mukund Ramakrishnan, Christopher A Miller, Timothy J Ley
2095 related Products with: PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells.
100ug Lyophilized100ul100ug Lyophilized100 μg100ug Lyophilized100ug Lyophilized100 1ml100ug Lyophilized201.00 flask1mg
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#38648484 2024/04/22
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Exacerbated atherosclerosis in progeria is prevented by progerin elimination in vascular smooth muscle cells but not endothelial cells.
HIgnacio Benedicto, Rosa M Carmona, Ana Barettino, Carla Espinós-Estévez, Pilar Gonzalo, Rosa M Nevado, Miguel de la Fuente-Pérez, María J Andrés-Manzano, Cristina González-Gómez, Loïc Rolas, Beatriz Dorado, Sussan Nourshargh, Magda R Hamczyk, Vicente Andrés
2672 related Products with: Exacerbated atherosclerosis in progeria is prevented by progerin elimination in vascular smooth muscle cells but not endothelial cells.
1.00 flask1.00 flask1.00 flask1.00 flask1x10e7 cells1 mg-1 mg1x10e7 cells10 rxns10 ug
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#38648478 2024/04/22
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Individual transcription factors modulate both the micromovement of chromatin and its long-range structure.
The control of eukaryotic gene expression is intimately connected to highly dynamic chromatin structures. Gene regulation relies on activator and repressor transcription factors (TFs) that induce local chromatin opening and closing. However, it is unclear how nucleus-wide chromatin organization responds dynamically to the activity of specific TFs. Here, we examined how two TFs with opposite effects on local chromatin accessibility modulate chromatin dynamics nucleus-wide. We combine high-resolution diffusion mapping and dense flow reconstruction and correlation in living cells to obtain an imaging-based, nanometer-scale analysis of local diffusion processes and long-range coordinated movements of both chromatin and TFs. We show that the expression of either an individual transcriptional activator (CDX2) or repressor (SIX6) with large numbers of binding sites increases chromatin mobility nucleus-wide, yet they induce opposite coherent chromatin motions at the micron scale. Hi-C analysis of higher-order chromatin structures shows that induction of the pioneer factor CDX2 leads both to changes in local chromatin interactions and the distribution of A and B compartments, thus relating the micromovement of chromatin with changes in compartmental structures. Given that inhibition of transcription initiation and elongation by RNA Pol II has a partial impact on the global chromatin dynamics induced by CDX2, we suggest that CDX2 overexpression alters chromatin structure dynamics both dependently and independently of transcription. Our biophysical analysis shows that sequence-specific TFs can influence chromatin structure on multiple architectural levels, arguing that local chromatin changes brought by TFs alter long-range chromatin mobility and its organization.Haitham A Shaban, Elias T Friman, Cédric Deluz, Armelle Tollenaere, Natalya Katanayeva, David M Suter
1430 related Products with: Individual transcription factors modulate both the micromovement of chromatin and its long-range structure.
69696962 Pieces/Box250 Units
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#38648454 2024/04/20
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Serum GAS6, sAXL, IL-10, NO, and BCL-2 levels are decreased in patients with Behçet's disease.
Behçet's disease (BD) is an autoimmune chronic systemic inflammatory disease characterized by a versatile clinical spectrum. Growth arrest specific protein 6 (GAS6)/soluble AXL (sAXL) signaling pathway draws attention in the resolution of inflammation, and its deficiency is associated with chronic inflammatory, autoimmune diseases, as well as clearance of apoptotic cells by phagocytes - efferocytosis. In this study, it was aimed to investigate whether GAS6/sAXL, interleukin (IL)-10, nitric oxide (NO), and BCL-2 levels were associated with inflammation and efferocytosis contributes to the pathogenesis of BD.Gulden Baskol, Merve Ö Yetkin, Duygu G Sevim, Kenan Guclu, Hatice Arda, Hatice Saracoglu, Kamran Gahramanov, Cem Evereklioglu