Importance of the second extracellular loop for melatonin MT1 receptor function and absence of melatonin binding in GPR50. productsSearch results for: Importance of the second extracellular loop for melatonin MT1 receptor function and absence of melatonin binding in GPR50.
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2017/10/27
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Importance of the second extracellular loop for melatonin MT receptor function and absence of melatonin binding in GPR50.
Recent crystal structures of GPCRs have emphasized the previously unappreciated role of the second extracellular (E2) loop in ligand binding and gating and receptor activation. Here, we have assessed the role of the E2 loop in the activation of the melatonin MT receptor and in the inactivation of the closely related orphan receptor GPR50.Nathalie Clement, Nicolas Renault, Jean-Luc Guillaume, Erika Cecon, Anne-Sophie Journé, Xavier Laurent, Kenjiro Tadagaki, Francis Cogé, Arnaud Gohier, Philippe Delagrange, Philippe Chavatte, Ralf Jockers
