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MEK5 is activated by shear stress, activates ERK5 and induces KLF4 to modulate TNF responses in human dermal microvascular endothelial cells.

ECs lining arteries respond to LSS by suppressing pro-inflammatory changes, in part through the activation of MEK5, ERK5 and induction of KLF4. We examined if this anti-inflammatory pathway operates in human ECs lining microvessels, the principal site of inflammatory responses.
Paul R Clark, Todd J Jensen, Martin S Kluger, Maurice Morelock, Adedayo Hanidu, Zhenhao Qi, Revati J Tatake, Jordan S Pober

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