Macrophage-derived MCPIP1 mediates silica-induced pulmonary fibrosis via autophagy. productsSearch results for: Macrophage-derived MCPIP1 mediates silica-induced pulmonary fibrosis via autophagy.
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2016/10/25
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Macrophage-derived MCPIP1 mediates silica-induced pulmonary fibrosis via autophagy.
Silicosis is characterized by accumulation of fibroblasts and excessive deposition of extracellular matrix. Monocyte chemotactic protein-1-induced protein 1 (MCPIP1) plays a critical role in fibrosis induced by SiO. However, the details of the downstream events of MCPIP1 activity in pulmonary fibrosis remain unclear. To elucidate the role of MCPIP1-induced autophagy in SiO-induced fibrosis, both the upstream molecular mechanisms and the functional effects of SiO on cell apoptosis, proliferation and migration were investigated.Haijun Liu, Shencun Fang, Wei Wang, Yusi Cheng, Yingming Zhang, Hong Liao, Honghong Yao, Jie Chao
