Search results for: Methyltransferase G9a Assay Kit
#36840458 2023/02/01 To Up
High Expression of G9a Induces Cisplatin Resistance in Hepatocellular Carcinoma.
Chemotherapeutic drug resistance is the main obstacle that affects the efficacy of current therapies of hepatocellular carcinoma (HCC), which needs to be addressed urgently. High expression of histone methyltransferase G9a was reported to play a pivotal role in the progression of HCC. Regulatory mechanism of aberrant activation of G9a in HCC and the association with subsequent cisplatin (DDP) resistance still remains ambiguous. This study strived to investigate mechanism of G9a overexpression and its impact on cisplatin resistance in HCC cells.Junhao Fu, Min Yu, Wenxia Xu, Shian Yu
1812 related Products with: High Expression of G9a Induces Cisplatin Resistance in Hepatocellular Carcinoma.
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#35176466 2022/02/15 To Up
Cinobufagin induces FOXO1-regulated apoptosis, proliferation, migration, and invasion by inhibiting G9a in non-small-cell lung cancer A549 cells.
Bufonis (VB), an animal drug called Chansu in China, is the product of the secretion of Bufo gargarizans Cantor or B. melanostictus Schneider. As a traditional Chinese medicine (TCM) for a long time, it has been widely used in the treatment of heart failure, ulcer, pain, and various cancers. Cinobufaginn (CNB), the cardiotonic steroid or bufalene lactone extracted from VB, has the effects of detoxification, detumescence, and analgesia.Lingling Zhang, Bing Liang, Huan Xu, Yanju Gong, Wangming Hu, Zhong Jin, Xiao Wu, Xiongbin Chen, Min Li, Liangqin Shi, Yaping Shi, Yong Wang, Lan Yang
1876 related Products with: Cinobufagin induces FOXO1-regulated apoptosis, proliferation, migration, and invasion by inhibiting G9a in non-small-cell lung cancer A549 cells.
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#32774698 2020/07/15 To Up
The combination of G9a histone methyltransferase inhibitors with erythropoietin protects heart against damage from acute myocardial infarction.
This study tested the hypothesis that combined histone methyltransferase G9a inhibitor (i.e., UNC0638) and erythropoietin (EPO) was superior to either one alone for protecting myocardium from acute myocardial infarction (AMI) damage.Pei-Hsun Sung, Chi-Wen Luo, John Y Chiang, Hon-Kan Yip
1702 related Products with: The combination of G9a histone methyltransferase inhibitors with erythropoietin protects heart against damage from acute myocardial infarction.
48 assays 96 assays 50 ug48 assays 100 µg96 assays 48 assays 96 assays 200 100 reactions100.00 ulRelated Pathways
#24850177 2014/05/22 To Up
Expression of proteins involved in epigenetic regulation in human cutaneous melanoma and peritumoral skin.
Epigenetic processes play a critical role in melanoma development. However, little is known about proteins responsible for epigenetic transformations in melanoma cells. The processes in the peritumoral skin within the excision margin are almost unstudied. We studied the changes in expression of 112 proteins involved in epigenetic regulation of gene expression in the human cutaneous melanoma and its peritumoral zone using "The Proteomic Antibody Microarrays" (GRAA2, Sigma-Aldrich). Dimethylated histone H3 at lysines 4 and 9 as well as proteins involved in the regulation of transcription (histone deacetylases HDAC-1 and HDAC-11, DNA methyl-binding protein Kaiso), cell cycle control (protein kinases Aurora-В and PKR, chromosome protein CENP-E , and phosphorylated and acetylated histone H3), DNA repair (phosphorylated histone H2AX), and nuclear protein import (importins α3 and α5/7) were over-expressed in the melanoma tissue as compared with normal skin. At the same time, HDAC-10 and proliferating cell nuclear antigen PCNA were downregulated. In the peritumoral skin, at the excision margin (1-2 cm from the melanoma edge), we observed similar changes in expression of these proteins and, additionally, over-expression of arginine methyltransferases PRMT5 and NAD-dependent histone deacetylase SIR2. Histone methyltransferase G9a and metastasis-associated protein 2 were downregulated. Therefore, epigenetic regulation that requires histone modifications and expression of some regulatory proteins is of importance for melanoma development and propagation. The observed changes in the peritumoral skin may indicate the epigenetic pre-tuning in this zone possibly involved in malignant transformation. These results can be potentially useful for melanoma diagnostics and targeted therapy.Anatoly Uzdensky, Svetlana Demyanenko, Mikhail Bibov, Svetlana Sharifulina, Oleg Kit, Yury Przhedetski, Viktoria Pozdnyakova
1535 related Products with: Expression of proteins involved in epigenetic regulation in human cutaneous melanoma and peritumoral skin.
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