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Search results for: Monoclonal Anti-Bone Morphogenetic Protein 2 produced in mouse Antibody

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#32249544   2020/07/30 To Up

Therapeutic Effects of Anti-Bone Morphogenetic Protein and Activin Membrane-Bound Inhibitor Treatment in Psoriasis and Arthritis.

The transforming growth factor β (TGFβ) inhibitor BAMBI (bone morphogenetic protein and activin membrane-bound inhibitor) has been shown to control differentiation of CD4+ T lymphocytes into either tolerogenic Treg cells or pathogenic Th17 cells, through the regulation of TGFβ and interleukin-2 (IL-2) signaling strength. The present study was undertaken to explore the potential beneficial effects of this strategy of pharmacologic inhibition using novel anti-BAMBI monoclonal antibodies (mAb) in different experimental murine models of chronic skin and joint inflammatory/autoimmune disease.
Pilar Alvarez, Juan Jesús Augustín, Esther Tamayo, Marcos Iglesias, Olga Acinas, María Angeles Mendiguren, José Andrés Vázquez, Fernanda Genre, David San Segundo, Jesús Merino, Ramón Merino

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