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Search results for: Mouse Anti-Human Endothelin 1 Antibodies

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A bone metastasis model with osteolytic and osteoblastic properties of human lung cancer ACC-LC-319/bone2 in natural killer cell-depleted severe combined immunodeficient mice.

Lung cancer is commonly associated with multiple-organ metastasis, and bone is a frequent metastatic site for lung cancer. Lung cancer frequently develops osteolytic, and less frequently osteoblastic, metastasis to bone. Osteolytic metastasis models of lung cancer have been reported, but no osteoblastic metastasis model is available for lung cancer. In the present study, we established a reproducible model of human lung cancer with both osteolytic and osteoblastic changes in natural killer cell-depleted severe combined immunodeficient mice. Intravenous inoculation of ACC-LC-319/bone2 cells resulted in the development of metastatic colonies in the lung, liver, and bone of the mice. As assessed sequentially by X-ray photographs, osteolytic bone lesions were observed by day 28, and then osteoblastic lesions were detected by day 35. Histological examination revealed the presence of bony spurs, a hallmark of osteoblastic bone metastasis, where osteoclasts were hardly observed. Treatment with an anti-human vascular endothelial growth factor antibody, bevacizumab, as well as zoledronate, inhibited the number of experimental bone metastases, including osteoblastic changes produced by ACC-LC-319/bone2 cells. These results indicate that our bone metastasis model by ACC-LC319/bone2 might be useful to understand the molecular pathogenesis of osteolytic and osteoblastic metastasis, and to identify molecular targets to control bone metastasis of lung cancer.
Shinsaku Otsuka, Masaki Hanibuchi, Kenji Ikuta, Seiji Yano, Hisatsugu Goto, Hirokazu Ogino, Tadaaki Yamada, Soji Kakiuchi, Yasuhiko Nishioka, Takashi Takahashi, Saburo Sone

2996 related Products with: A bone metastasis model with osteolytic and osteoblastic properties of human lung cancer ACC-LC-319/bone2 in natural killer cell-depleted severe combined immunodeficient mice.



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Comparative sequences of canine and feline endothelin-1.

Endothelin-1 (ET-1, "mature ET-1") is a potent vasoconstrictor peptide that is made along with "big ET-1" from its precursor, preproET-1. Increased plasma concentrations of ET-1 and big ET-1 occur with various forms of cardiovascular disease in humans. Our laboratory is investigating plasma endothelins as diagnostic tests of cardiovascular disease in dogs and cats; however, commercial immunoassays designed specifically for use in dogs and cats are limited.
Alexander W Biondo, Charles E Wiedmeyer, David D Sisson, Philip F Solter

2393 related Products with: Comparative sequences of canine and feline endothelin-1.

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Distribution of endothelin-1-like activity in the cochlea of normal guinea pigs.

Distribution of endothelin-1 (ET-1) in the cochlea of normal guinea pigs was determined by immunohistochemistry. ET-1 activity was identified with the mouse anti-human ET-1 IgG1 monoclonal antibody. ET-1 activity was distributed in the modiolus, spiral ligament, stria vascularis, spiral prominence. Reissner's membrane, supporting cells of the organ of Corti and spiral ganglion cells. These findings suggest that ET-1 may be involved in the regulation of fluid volume and ions of the cochlea.
K Jinnouchi, S Tomiyama, R Pawankar, T Ikezono, T Yagi

2339 related Products with: Distribution of endothelin-1-like activity in the cochlea of normal guinea pigs.



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Distribution of endothelin-1-like activity in the vestibule of normal guinea pigs.

Endothelin (ET) has been revealed to be a local hormonal regulator of pressure, fluid, ions and neurotransmitters. In order to investigate the mechanism of homeostasis within the microenvironment of the inner ear, the present study has examined the distribution of ET in the vestibule of normal guinea pigs, by immunohistochemistry using mouse antihuman ET IgG1 monoclonal antibody. ET-like activity was identified in the sensory epithelial cells, supporting cells, dark cells, transitional cells, vestibular membrane, semicircular wall cells and vestibular ganglion cells. These findings suggest that ET may play an important role in maintaining homeostasis of the vestibule.
K Jinnouchi, S I Tomiyama, R Pawankar

1177 related Products with: Distribution of endothelin-1-like activity in the vestibule of normal guinea pigs.



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