Only in Titles

           Search results for: Mouse Anti-Human GH Antibodies    

paperclip

#1299418   1993/05/18 Save this To Up

Pattern of antigens A and B distribution on the surface of AB group red blood cells--an argument in support of the concept of "genetic oscillation".

Using a mixture of mouse monoclonal antibodies anti red blood cell (RBC) AgA and human antibodies anti RBC AgB coupled to fluorescein isothiocyanate (FITC) conjugated goat antimouse monoclonal antibodies and to phycoerythrin (PE) conjugated goat antihuman monoclonal antibodies, we obtained the distribution of these antigens on the AB RBC surface. The analysis of 30 samples of 30,000-100,000 RBCs each was carried out using flow cytometry and revealed three kinds of AB RBC populations: (1) a population characterized by maximum concentration of AgA and minimum concentration of AgB; (2) a complementary population characterized by minimum concentration of AgA and maximum concentration of AgB; (3) an intermediary equilibrated population with about equal concentrations of the A and B antigens. This pattern corresponds to the pattern of oscillating genetic activity defined as "genetic oscillation", a concept amply discussed in the paper.

1719 related Products with: Pattern of antigens A and B distribution on the surface of AB group red blood cells--an argument in support of the concept of "genetic oscillation".

Blood Group Lewis a antib Cytokine (Mouse) Antibody Cytokine (Rat) Antibody A Th1 Th2 Th17 (Human) Anti Rabbit Anti-Human Red Blo Anti-actin binding protei Anti actin binding protei Anti-actin binding protei Anti actin binding protei Interleukin-34 IL34 (N-t Interleukin-34 IL34 anti anti AB human blood antig

Related Pathways

paperclip

#7094888   1982/09/24 Save this To Up

The same region of human growth hormone is involved in its binding to various receptors.

The Fab fragments of three monoclonal antihuman GH (anti-hGH) antibodies, among five tested, inhibited the binding of the hormone to the receptors of the human lymphoid cell line IM-9 and liver membranes of the pregnant rabbit. The results were similar for the receptors of human lymphocytes and rabbit liver, suggesting that both receptors reacted with the same region of the hormone. The Fab fragments of the most inhibitory antibody also inhibited the down-regulation by the hormone of the receptors on human lymphocytes. The fragments of this antibody completely blocked the binding of the hormone to the receptors of the rabbit liver, despite the fact that this carries two or more classes of receptors. Therefore, all of these various receptors apparently interact with the same region of the hormone. Three synthetic peptides extending from residues 19-128, 73-128, and 98-128 failed to inhibit the binding of hGH to its lymphocyte or liver receptors however, these peptides reacted significantly with the monoclonal antibody, which was the strongest inhibitor of the interaction of hGH with the cellular receptor, confirming that the receptor-binding site of the hormone is in the amino-terminal part of the molecule and suggesting indirectly that the short sequences 98-128 participates in the constitution of the receptor-binding site of the hormone.

2750 related Products with: The same region of human growth hormone is involved in its binding to various receptors.

Human Growth Hormone anti Human Growth Hormone anti Human Growth Hormone anti Goat Anti-Human Laforin ( Goat Anti-Human Fibroblas Goat Anti-Human Glutathio Goat Anti-Human MBD2 (iso Goat Anti-Human MDM2 (iso Goat Anti-Human NHERF2 (i Goat Anti-Human Nur77 TR3 Goat Anti-Human NHERF2 (i Goat Anti-Human SLIMMER F

Related Pathways