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Search results for: Mouse Anti-Human PTH Related Peptide Antibodies

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Parathyroid hormone-related protein regulates the growth of orthotopic human lung tumors in athymic mice.

Parathyroid hormone-related protein (PTHrP) has growth regulatory effects for many malignant cells and may influence the progression of carcinomas of the breast, prostate, and lung. In the current study, the authors investigated the in vivo and in vitro effects of PTHrP neutralizing antibody and PTHrP treatment on the growth of BEN cells, a human lung squamous cell carcinoma line that expresses PTHrP and its receptor.
R H Hastings, D W Burton, R A Quintana, E Biederman, A Gujral, L J Deftos

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Parathyroid hormone-related protein as a potential target of therapy for cancer-associated morbidity.

Proinflammatory cytokines are involved in the genesis of cancer-associated cachexia. Parathyroid hormone-related protein (PTHrP) is the causative agent in humoral hypercalcemia of malignancy (HHM) and is frequently secreted from various kinds of solid tumors as well as from adult T-cell leukemia/lymphoma. PTHrP, like PTH, acts on PTH receptor type 1 (PTH1R). Activation of PTH1R may lead to stimulation of secretion of proinflammatory cytokines. It is expected, therefore, that PTHrP constitutes a key factor in the activation of the proinflammatory and cachectogenic cytokine network and consequently in the development of cachexia in patients with cancer.
E Ogata

2812 related Products with: Parathyroid hormone-related protein as a potential target of therapy for cancer-associated morbidity.

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