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Search results for: Mouse Anti-Human TGFB1 Antibodies

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#36505477   2022/11/23 To Up

Nasal administration of anti-CD3 monoclonal antibody modulates effector CD8+ T cell function and induces a regulatory response in T cells in human subjects.

Parenteral anti-CD3 Mab (OKT3) has been used to treat transplant rejection and parental administration of a humanized anti-CD3 Mab (Teplizumab) showed positive effects in diabetes. Nasal administration of anti-CD3 Mab has not been carried out in humans. Nasal anti-CD3 Mab suppresses autoimmune diseases and central nervous system (CNS) inflammation in animal models. We investigated the safety and immune effects of a fully humanized, previously uncharacterized nasal anti-CD3 Mab (Foralumab) in humans and its stimulatory properties.
Tanuja Chitnis, Belinda J Kaskow, Junning Case, Katherine Hanus, Zhenhua Li, Johnna F Varghese, Brian C Healy, Christian Gauthier, Taylor J Saraceno, Shrishti Saxena, Hrishikesh Lokhande, Thais G Moreira, Jonathan Zurawski, Rachel E Roditi, Regan W Bergmark, Federico Giovannoni, Maria F Torti, Zhaorong Li, Francisco Quintana, William A Clementi, Kunwar Shailubhai, Howard L Weiner, Clare M Baecher-Allan

2032 related Products with: Nasal administration of anti-CD3 monoclonal antibody modulates effector CD8+ T cell function and induces a regulatory response in T cells in human subjects.

100ug Lyophilized100ug Lyophilized0.1ml (1mg/ml)1 mg100 μg100 TESTS25 TESTS100ug Lyophilized100 μg100ug Lyophilized100 μg

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#21124798   2010/11/24 To Up

TGF-β induces surface LAP expression on murine CD4 T cells independent of Foxp3 induction.

It has been reported that human FOXP3(+) CD4 Tregs express GARP-anchored surface latency-associated peptide (LAP) after activation, based on the use of an anti-human LAP mAb. Murine CD4 Foxp3(+) Tregs have also been reported to express surface LAP, but these studies have been hampered by the lack of suitable anti-mouse LAP mAbs.
Takatoku Oida, Howard L Weiner

2934 related Products with: TGF-β induces surface LAP expression on murine CD4 T cells independent of Foxp3 induction.

25 μg1 mg100 μg100 Tests50ml25 Tests0.1ml (1mg/ml)100 TESTS100 Tests5

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