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           Search results for: Mouse Anti-Troponin- I (Cardiac) Proteins    

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#23316321   2013/01/14 Save this To Up

Successful use of mRNA-nucleofection for overexpression of interleukin-10 in murine monocytes/macrophages for anti-inflammatory therapy in a murine model of autoimmune myocarditis.

Overexpression of interleukin-10 (IL-10) in murine CD11b(+) monocytes/macrophages via GMP-adapted mRNA-nucleofection was expected to improve clinical outcome and reduce adverse side effects in autoimmune myocarditis. This study represents the proof of principle for a novel anti-inflammatory therapy using overexpression of IL-10 in murine monocytes/macrophages by mRNA-nucleofection for the treatment of autoimmune myocarditis.

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Rat Anti-Mouse Interleuki Rat Anti-Mouse Interleuki Mouse Anti-Human Interleu Mouse Anti-Human Interleu Hamster anti mouse Interl Rat monoclonal anti mouse Rat monoclonal anti mouse Rat monoclonal anti mouse Rat monoclonal anti mouse Rat monoclonal anti mouse Rat monoclonal anti mouse Rat monoclonal anti mouse

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#3899330   1985/11/01 Save this To Up

A monoclonal antitroponin-T cross-reacts with smooth muscle and nonmuscle cells.

A mouse monoclonal antibody was prepared against chicken skeletal troponin-T. Indirect immunofluorescence microscopy of smooth muscle and nonmuscle cells indicated the presence of a cross-reactive component(s). In contrast to the definitive I-band reactivity in striated muscle, the smooth muscle components from chicken gizzard, lung, and small intestine showed diffuse, cytoplasmic staining. A filamentous pattern which converged on a perinuclear focus was observed in interphase cells (356 fibroblasts). This cross-reaction was determined to be associated with microtubules. To assess the extent of occurrence of the cross-reactive species, representatives of both the fungal and plant kingdoms were examined. In both Dictyostelium discoideum and cells of the onion (Allium) root tip, the antitroponin-T detected cross-reactive components associated with microtubules. Immunoblot experiments conducted to determine the molecular specificity of the antibody showed cross-reaction with only troponin-T in striated muscle preparations. Similar experiments with the antitroponin-T on chicken gizzard smooth muscle indicated reactivity with two bands whose electrophoretic mobilities are within the range reported for striated muscle troponin-T. Our results indicate the presence of a highly conserved troponin-T cross-reactive determinant in all muscle types, as well as nonmuscle cells. They raise the possibility of a troponin-like molecule in smooth muscle and nonmuscle cells which may confer calcium sensitivity in their cellular filament systems.

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Mouse Anti-SM Myosin (Smo Goat Anti-Human, Mouse, R Rat monoclonal anti mouse Rat monoclonal anti mouse Muscle disease spectrum ( Smooth muscle and striate Sarcoma tissue array of s Monoclonal Anti-Actin, β Monoclonal Anti Actin, β Monoclonal Anti-Actin, β Monoclonal Anti Actin, β Monoclonal Anti-Actin, β

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