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           Search results for: Mouse anti human Growth Hormone Anti-Human antibodies   

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Parathyroid hormone-related protein regulates the growth of orthotopic human lung tumors in athymic mice.

Parathyroid hormone-related protein (PTHrP) has growth regulatory effects for many malignant cells and may influence the progression of carcinomas of the breast, prostate, and lung. In the current study, the authors investigated the in vivo and in vitro effects of PTHrP neutralizing antibody and PTHrP treatment on the growth of BEN cells, a human lung squamous cell carcinoma line that expresses PTHrP and its receptor.

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Parathyroid Hormone Relat Parathyroid Hormone Relat Mouse Anti hPTH PTH rP Ta Mouse Anti-Human LDL Rece Rabbit Anti-TNIP2 ABIN2 T Mouse anti human Growth H Goat Anti-Human Fibroblas Recombinant Human p16-INK Prolactin-Inducible Prote Rabbit Anti-Cell death in Human, Agouti–Related P Proteins and Antibodies H

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Suppression of immunological response against a transgene product delivered from microencapsulated cells.

A potential obstacle to successful gene therapy for some patients is the in vivo production of neutralizing antibodies against the recombinant therapeutic product delivered. To mimic this clinical situation, we implanted microencapsulated recombinant cells producing human growth hormone into C57B1/6 mice to provoke antihuman growth hormone antibody production. We then investigated the efficacy of different immunosuppressive treatments to inhibit the development of neutralizing antibodies. The experimental mice were treated with either an immunosuppressive drug (FK506 or cyclophosphamide), a cytokine (interferon-gamma [IFN-gamma] or interleukin-12 [IL-12], or a monoclonal antibody (anti-CD4, anti-gp39, or CTLA4-Ig). Serum human growth hormone and mouse anti-human growth hormone antibody levels were measured by enzyme-linked immunosorbent assay (ELISA) for 4 weeks. There were three patterns of response noted among the seven treatment groups. First, the mice receiving IFN-gamma, IL-12, anti-gp39, or CTLA4-Ig were similar to the untreated controls-no suppression of anti-hGH antibodies and no improvement in delivery of hGH. Next, the mice receiving FK506 or cyclosphosphamide showed > or = 90% suppression of antibodies but also no improvement in product delivery. Last, the mice receiving anti-CD4 showed almost complete antibody suppression over 1 month postimplantation. Furthermore, only anti-CD4 permitted a sustained level of human growth hormone delivery to day 28, in contrast to the controls whose human growth hormone delivery was undetectable by day 14 postimplantation. Hence, the use of anti-CD4 inhibited formation of neutralizing antibodies against a recombinant gene product delivered in vivo, and allowed prolonged delivery of a foreign protein. Its role as adjunct treatment for appropriate patients receiving gene therapy should be examined further.

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Mouse Anti-Human Fibrobla MarkerGene™ Cellular Se Primary antibody IKK bet MOUSE ANTI CANINE DISTEMP Anti beta3 AR Human, Poly ELISA Microplate Reader ( HyAgarose™ HR Agarose, Fontana-Masson Stain Kit anti CD16 NK cells, monoc Primary antibody DRAK1 A Nrf antioxidant pathway A Anti-bodywall muscle cell

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The same region of human growth hormone is involved in its binding to various receptors.

The Fab fragments of three monoclonal antihuman GH (anti-hGH) antibodies, among five tested, inhibited the binding of the hormone to the receptors of the human lymphoid cell line IM-9 and liver membranes of the pregnant rabbit. The results were similar for the receptors of human lymphocytes and rabbit liver, suggesting that both receptors reacted with the same region of the hormone. The Fab fragments of the most inhibitory antibody also inhibited the down-regulation by the hormone of the receptors on human lymphocytes. The fragments of this antibody completely blocked the binding of the hormone to the receptors of the rabbit liver, despite the fact that this carries two or more classes of receptors. Therefore, all of these various receptors apparently interact with the same region of the hormone. Three synthetic peptides extending from residues 19-128, 73-128, and 98-128 failed to inhibit the binding of hGH to its lymphocyte or liver receptors however, these peptides reacted significantly with the monoclonal antibody, which was the strongest inhibitor of the interaction of hGH with the cellular receptor, confirming that the receptor-binding site of the hormone is in the amino-terminal part of the molecule and suggesting indirectly that the short sequences 98-128 participates in the constitution of the receptor-binding site of the hormone.

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Human Growth Hormone anti Goat Anti-Human Vitamin D Goat Anti-Human Nur77 TR3 Goat Anti-Human MDM2 (iso Goat Anti-Human NHERF2 (i Goat Anti-Human SLIMMER F Goat Anti-Human Laforin ( Human Growth Hormone anti Goat Anti-Human Fibroblas Goat Anti-Human Glutathio Goat Anti-Human TOM1L1 SR Human Growth Hormone anti

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