NFkB p65 Antibody (Clone 2A12A7) productsSearch results for: NFkB p65 Antibody (Clone 2A12A7)
#36845129 
2023/02/08
To Up
Dual stimulation by autoantigen and CpG fosters the proliferation of exhausted rheumatoid factor-specific CD21 B cells in hepatitis C virus-cured mixed cryoglobulinemia.
Hepatitis C virus (HCV) causes mixed cryoglobulinemia (MC) by driving clonal expansion of B cells expressing B cell receptors (BCRs), often encoded by the VH1-69 variable gene, endowed with both rheumatoid factor (RF) and anti-HCV specificity. These cells display an atypical CD21low phenotype and functional exhaustion evidenced by unresponsiveness to BCR and Toll-like receptor 9 (TLR9) stimuli. Although antiviral therapy is effective on MC vasculitis, pathogenic B cell clones persist long thereafter and can cause virus-independent disease relapses.Martina Del Padre, Ramona Marrapodi, Ylenia A Minafò, Eva Piano Mortari, Giovanna Radicchio, Chiara Bocci, Laura Gragnani, Alessandro Camponeschi, Stefania Colantuono, Lucia Stefanini, Stefania Basili, Rita Carsetti, Massimo Fiorilli, Milvia Casato, Marcella Visentini
