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Search results for: PCP antibody, Monoclonal Antibodies, Host Mouse

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Complement and Fc function are required for optimal antibody prophylaxis against Pneumocystis carinii pneumonia.

Pneumocystis carinii is an opportunistic fungal pathogen that causes P. carinii pneumonia (PCP) in the immunocompromised host. We investigated the role of antibody Fc-mediated function in passive prophylaxis against the development of PCP in SCID mice. By comparison of anti-mouse P. carinii immunoglobulin G1 monoclonal antibody (MAb) 4F11(G1) and its F(ab')2 derivative in an intranasal immunoprophylaxis model, we determined that Fc-mediated function is required for maximum effect of this antibody. Comparison of efficacy of antibody prophylaxis in SCID mice depleted of complement to that in nondepleted mice demonstrated that complement fixation by MAb 4F11(G1) is also necessary for optimal effect of passively administered antibody, although residual protection was observed in complement-depleted SCID mice. The necessity of complement for optimal PCP prophylaxis by MAb 4F11(G1) suggests that complement may play a role in antibody-mediated protection against development of PCP.
Jesse Wells, Constantine G Haidaris, Terry W Wright, Francis Gigliotti

1055 related Products with: Complement and Fc function are required for optimal antibody prophylaxis against Pneumocystis carinii pneumonia.

0.2 mg200ug 100ul25 µg100ug100ug100ug100μg1,000 tests100ug100ug25

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Tamarin model of pneumococcal bacteremia.

Tamarins (Saguinus labiatus) were utilized to study host defenses against pneumococcal bacteremia. Tamarins had a poor antibody response to immunization with varying doses of pneumococcal capsular polysaccharide (PCP) vaccine (2 of 15 positive) or to infection with serotype 7F Streptococcus pneumoniae (2 of 14 positive). Tamarins were protected against challenge with a lethal dose of serotype 7F S. pneumoniae if the bacteria were preopsonized with human immune globulin intravenous or if the tamarins were injected with the immune globulin 30 min before challenge. There was minimal protection utilizing a mouse monoclonal anti-type 7F PCP antibody.
D S Chudwin, S G Artrip, J D Ogden, G Schiffman

1284 related Products with: Tamarin model of pneumococcal bacteremia.

5 G18 kgs

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