Only in Titles

           Search results for: PCP antibody, Monoclonal Antibodies, Host Mouse   

paperclip

#16368994   2005/12/21 Save this To Up

Complement and Fc function are required for optimal antibody prophylaxis against Pneumocystis carinii pneumonia.

Pneumocystis carinii is an opportunistic fungal pathogen that causes P. carinii pneumonia (PCP) in the immunocompromised host. We investigated the role of antibody Fc-mediated function in passive prophylaxis against the development of PCP in SCID mice. By comparison of anti-mouse P. carinii immunoglobulin G1 monoclonal antibody (MAb) 4F11(G1) and its F(ab')2 derivative in an intranasal immunoprophylaxis model, we determined that Fc-mediated function is required for maximum effect of this antibody. Comparison of efficacy of antibody prophylaxis in SCID mice depleted of complement to that in nondepleted mice demonstrated that complement fixation by MAb 4F11(G1) is also necessary for optimal effect of passively administered antibody, although residual protection was observed in complement-depleted SCID mice. The necessity of complement for optimal PCP prophylaxis by MAb 4F11(G1) suggests that complement may play a role in antibody-mediated protection against development of PCP.

1069 related Products with: Complement and Fc function are required for optimal antibody prophylaxis against Pneumocystis carinii pneumonia.

MOUSE ANTI BOVINE ROTAVIR Mouse anti IgG Fc antibod Mouse anti Human IgG anti Androgen Receptor (Phosph Androgen Receptor (Phosph MOUSE ANTI BORRELIA BURGD Androgen Receptor (Ab 650 succinate-CoA ligase, GDP Complement factor H antib formin-like 1 antibody So Complement C2 antibody So succinate-CoA ligase, ADP

Related Pathways

  •  
  • No related Items
paperclip

#3114496   1987/10/20 Save this To Up

Tamarin model of pneumococcal bacteremia.

Tamarins (Saguinus labiatus) were utilized to study host defenses against pneumococcal bacteremia. Tamarins had a poor antibody response to immunization with varying doses of pneumococcal capsular polysaccharide (PCP) vaccine (2 of 15 positive) or to infection with serotype 7F Streptococcus pneumoniae (2 of 14 positive). Tamarins were protected against challenge with a lethal dose of serotype 7F S. pneumoniae if the bacteria were preopsonized with human immune globulin intravenous or if the tamarins were injected with the immune globulin 30 min before challenge. There was minimal protection utilizing a mouse monoclonal anti-type 7F PCP antibody.

2541 related Products with: Tamarin model of pneumococcal bacteremia.

Model 150 V T Ultrasonic ULTRASONIC HOMOGENIZERS: Model 300 V T Ultrasonic ULTRASONIC HOMOGENIZERS: Model 3000 Ultrasonic Hom ULTRASONIC HOMOGENIZERS: Horizontal Laminar Flow Horizontal Laminar Flow Horizontal Laminar Flow Vertical Laminar Flow Cle Vertical Laminar Flow Cle Horizontal Laminar Flow

Related Pathways