Search results for: Phalloidin-iFluor™ 532 Conjugate
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Nasopharyngeal carriage of invasive pneumococcal serotypes during childhood community-acquired alveolar pneumonia is associated with specific clinical presentation.Streptococcus pneumoniae (Pnc) serotypes differ in invasive potential. We examined whether community-acquired alveolar pneumonia (CAAP) in children carrying common recognized invasive pneumococcal serotypes (1, 5, 7F, 14 and 19A; PnIST) differs from CAAP in children carrying less invasive serotypes (non-PnIST) or no Pnc (Pnc-neg).
1248 related Products with: Nasopharyngeal carriage of invasive pneumococcal serotypes during childhood community-acquired alveolar pneumonia is associated with specific clinical presentation.Multiple organ tumor tiss MOUSE ANTI APAAP COMPLEX, Rabbit Anti-Nkx2.5 Cardia Anti Mouse B220 (B cell s Rabbit Anti-Nkx2.5 Cardia BACTERIOLOGY CAMPYLOBACTE MOUSE ANTI BOVINE ROTAVIR 10X PHOSPHATE BUFFERED SA NATIVE HUMAN PROLACTIN, P Rabbit Anti-Nkx2.5 Cardia Rabbit Anti-Nkx2.5 Cardia ESCHERICHIA COLI clinical
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An adaptable two-lens high-resolution objective for single-site resolved imaging of atoms in optical lattices.In this paper, we present a high-resolution, simple, and versatile imaging system for single-site resolved imaging of atoms in optical lattices. The system, which relies on an adaptable infinite conjugate two-lens design, has a numerical aperture of 0.52, which can in the ideal case be further extended to 0.57. It is optimized for imaging on the sodium D-line but allows us to tune the objective's diffraction limited performance between 400 nm and 1000 nm by changing the distance between the two lenses. Furthermore, the objective is designed to be integrated into a typical atomic physics vacuum apparatus where the operating distance can be large (>20 mm) and diffraction limited performance still needs to be achieved when imaging through thick vacuum windows (6 mm to 10 mm). Imaging gold nanoparticles, using a wavelength of 589 nm which corresponds to the D-line of sodium atoms, we measure diffraction limited performance and a resolution corresponding to an Airy radius of less than 0.7 µm, enabling potential single-site resolution in the commonly used 532 nm optical lattice spacing.
2285 related Products with: An adaptable two-lens high-resolution objective for single-site resolved imaging of atoms in optical lattices.Goat Anti-Influenza A Vir Rabbit Anti-Integrin β2 Colon carcinoma antibody Thyroid cancer and adenom TRAF2 & ACTG1 Protein Pro Rabbit Anti-Insulin Recep Mouse AntiInfluenza A Tar CASP3 & TRAF1 Protein Pro Rabbit Anti-G protein alp Multiple organ cancer fro IKBKB & CTNNB1 Protein Pr RPS6KA5 & RELA Protein Pr
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Comparison of two schedules of two-dose priming with the ten-valent pneumococcal conjugate vaccine in Nepalese children: an open-label, randomised non-inferiority controlled trial.Nepalese infants receive ten-valent pneumococcal conjugate vaccine (PCV10) with a 1 month interval between priming doses for programmatic reasons. We aimed to investigate whether immune responses to PCV10 serotypes were non-inferior if the second priming dose of PCV10 was delivered at a 1 month interval as opposed to a 2 month interval.
2839 related Products with: Comparison of two schedules of two-dose priming with the ten-valent pneumococcal conjugate vaccine in Nepalese children: an open-label, randomised non-inferiority controlled trial.Rabbit Anti-NOS-2 iNOS Po Rabbit Anti-TNIP2 ABIN2 T FDA Standard Frozen Tissu Rabbit Anti-NOS-2 iNOS Po Syringe pump can be contr Rabbit Anti-TNIP2 ABIN2 T Rabbit Anti-Insulin Recep Rabbit Anti-Insulin Recep Rabbit Anti-ING1 p33 Poly Rabbit Anti-Insulin Recep Mouse Anti-Insulin(1G11) Rabbit Anti-IAA (Indole-3
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Cholesterol Functionalization of Gold Nanoparticles Enhances Photoactivation of Neural Activity.Gold nanoparticles (AuNPs) attached to the extracellular leaflet of the plasma membrane of neurons can enable the generation of action potentials (APs) in response to brief pulses of light. Recently described techniques to stably bind AuNP bioconjugates directly to membrane proteins (ion channels) in neurons enable robust AP generation mediated by the photoexcited conjugate. However, a strategy that binds the AuNP to the plasma membrane in a non protein-specific manner could represent a simple, single-step means of establishing light-responsiveness in multiple types of excitable neurons contained in the same tissue. On the basis of the ability of cholesterol to insert into the plasma membrane, here we test whether AuNP functionalization with linear dihydrolipoic acid-poly(ethylene) glycol (DHLA-PEG) chains that are distally terminated with cholesterol (AuNP-PEG-Chol) can enable light-induced AP generation in neurons. Dorsal root ganglion (DRG) neurons of rat were labeled with 20 nm diameter spherical AuNP-PEG-Chol conjugates wherein ∼30% of the surface ligands (DHLA-PEG-COOH) were conjugated to PEG-Chol. Voltage recordings under current-clamp conditions showed that DRG neurons labeled in this manner exhibited a capacity for AP generation in response to microsecond and millisecond pulses of 532 nm light, a property attributable to the close tethering of AuNP-PEG-Chol conjugates to the plasma membrane facilitated by the cholesterol moiety. Light-induced AP and subthreshold depolarizing responses of the DRG neurons were similar to those previously described for AuNP conjugates targeted to channel proteins using large, multicomponent immunoconjugates. This likely reflected the AuNP-PEG-Chol's ability, upon plasmonic light absorption and resultant slight and rapid heating of the plasma membrane, to induce a concomitant transmembrane depolarizing capacitive current. Notably, AuNP-PEG-Chol delivered to DRG neurons by inclusion in the buffer contained in the recording pipet/electrode enabled similar light-responsiveness, consistent with the activity of AuNP-PEG-Chol bound to the inner (cytofacial) leaflet of the plasma membrane. Our results demonstrate the ability of AuNP-PEG-Chol conjugates to confer timely stable and direct responsiveness to light in neurons. Further, this strategy represents a general approach for establishing excitable cell photosensitivity that could be of substantial advantage for exploring a given tissue's suitability for AuNP-mediated photocontrol of neural activity.
2895 related Products with: Cholesterol Functionalization of Gold Nanoparticles Enhances Photoactivation of Neural Activity.Ofloxacin CAS Number [824 Rabbit Anti-SPHK2 Polyclo Cell Meter™ Generic Flu Rabbit Anti-ASB17 Polyclo Rabbit Anti-PBEF1(CT) Pol Rabbit Anti-Fetuin beta P Rabbit Anti-HHV8 ORF K2 P Ceruloplasmin Colorimetri Rabbit Anti-TGF Beta R3 P MarkerGene™ Cellular Se Rabbit Anti-MST4 Polyclon Rabbit Anti-RHCG Polyclon
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Adverse events after vaccination among HIV-positive persons, 1990-2016.Human immunodeficiency virus (HIV) causes immune dysregulation, potentially affecting response to vaccines in infected persons. We investigated if unexpected adverse events (AEs) or unusual patterns of AEs after vaccination were reported among HIV-positive persons. We searched for domestic reports among HIV-positive persons to the Vaccine Adverse Event Reporting System (VAERS) during 1990-2016. We analyzed reports by age group (<19 and ≥19 years), sex, serious or non-serious status, live vaccine type (live versus inactivated), AEs reported, and CD4 counts. Of 532,235 reports received, 353 (0.07%) described HIV-positive persons, of whom 67% were aged ≥19 years, and 57% were male; most reports (75%) were non-serious. The most commonly reported inactivated vaccines were pneumococcal polysaccharide (27%) and inactivated influenza (27%); the mostly reported common live virus vaccines were combination measles, mumps, and rubella (8%) and varicella (6%). Injection site reactions were commonly reported (39%). Of 67 reports with CD4 counts available, 41 (61%) described persons immunocompromised at time of vaccination (CD4 count <500 cells/mm3), and differed from overall reports only in that varicella was the most common live virus vaccine (4 reports). Of 22 reports describing failure to protect against infection, 6 described persons immunocompromised at time of vaccination, among whom varicella vaccine was most common (3 reports). Of 66 reports describing live virus vaccines, 7 described persons with disseminated infection: 6 had disseminated varicella, 3 of whom had vaccine strain varicella-zoster virus. Of 18 reported deaths, 7 resulted from disseminated infection: 6 were among immunocompromised persons, 1 of whom had vaccine strain varicella-zoster virus. We identified no unexpected or unusual patterns of AEs among HIV-positive persons. These data reinforce current vaccine recommendations for this risk group. However, healthcare providers should know their HIV-positive patients' immune status because immunocompromising conditions can potentially increase the risk of rare, but severe, AEs following vaccination with live virus vaccines.
Isorbin (Fixed and killed pSIH1 H1 siLuc copGFP Pac Positive Control siRNA (G Amiloride Hydrochloride C Positive Control siRNA (G ASO positive Control Isorbin (Fixed and killed Mouse Anti-Gram Positive Positive Control siRNA (b HIV & FIV Positive Transd Positive Control siRNA (b Tetramethylrhodamine, eth
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Femtosecond Laser Ablation Synthesis of Aryl Functional Group Substituted Gold Nanoparticles.Femtosecond laser ablation synthesis of gold-aryl nanoparticles in solution was explored. Laser irradiation of the yellow solution of diazonium tetrachloroaurate(III) salt [C8F17-4-C6H4N≡N]AuCl4 in acetonitrile formed ruby red color of gold-aryl nanoparticles without the need for external chemical reducing agent. X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), X-ray powder diffraction (XRD), and nanodrop UV-Vis spectroscopy were used in the nanoparticles characterization. XPS showed the presence of the core–shell and the formation of gold(0) oxidation state only. The nanoparticles size distribution estimated by TEM is dependent on the duration of laser irradiation. Longer irradiation time resulted in decreasing the nanoparticles size. UV-Vis studies in acetonitrile showed that the absorption of gold(III) at 310 nm vanished with a concomitant formation of a plasmon absorbance at 532 nm due to the formation of “embryonic” gold-aryl nanoparticles. The novelty of this work is the in situ conjugation of core–shell structure without the need for adjusting the conjugate/gold ratio, chemicals-free synthesis from reducing agents and surfactants, synthesis of nanoparticles using gold salts unlike the common ablation of flat metal surfaces, and the use of reactive [AuCl4]− counter-ion that permits the co-deposition of gold and conjugates. Released solvated electrons and hydrogen radicals are believed to induce the reduction reaction of the gold salts. Isolation of pure nanoparticles is important for further biomedical applications including cellular uptake.
1449 related Products with: Femtosecond Laser Ablation Synthesis of Aryl Functional Group Substituted Gold Nanoparticles.Rabbit Anti-CD45 B220 Pol Rabbit Anti-IKK alpha + I Rabbit Anti-Hemoglobin Be Rabbit Anti-GAP43 Polyclo Rabbit Anti-Hemoglobin α Rabbit Anti-CD56 NCAM1 Po Rabbit Anti-Shigella Grou Rabbit Anti-Snail SNAI 1 Atto 655 Protein Labeling Rabbit Anti-Adenylosuccin Rabbit Anti-AGPB Alpha 1 Rabbit Anti-BZW2 Polyclon
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Amphiphilic lipopeptide significantly enhances uptake of charge-neutral splice switching morpholino oligonucleotide in spinal muscular atrophy patient-derived fibroblasts.Splice-switching antisense oligonucleotides (SSOs) are emerging therapeutics with two SSOs recently approved by the FDA for Duchenne muscular dystrophy and spinal muscular atrophy. SSOs are administered without any delivery vector and require large doses to achieve the therapeutic benefit, primarily due to their poor cellular uptake. Although cell-penetrating peptides (CPP) have shown great potential in delivering SSOs into cells, their capacity as delivery vector is limited. Here we have studied the effect of lipid conjugation on the cell permeability of a known CPP (ApoE). Myristic acid was coupled at the N-terminus of ApoE to a C-terminal cysteine residue. The myristoylated ApoE (Myr-ApoE) was conjugated to a maleimide functionalised phosphorodiamidate morpholino oligonucleotide (PMO). The Myr-ApoE-PMO conjugate showed no cytoxicity and had significantly higher efficiency in cell permeability with 30% higher splice-switching activity compared to ApoE-PMO. The self-assembly properties of this amphiphilic lipopeptide-PMO conjugate was assessed. Transmission electron microscopy showed formation of nanoparticles with amphiphile behaviour and spherical structure. The self-assembly of Myr-ApoE-PMO into nanoparticles enabled it to better bind to cell membranes and to be more efficiently taken up by fibroblast cells. These results showed that modification of physico-chemical properties of peptides to produce peptide amphiphiles enhances cellular uptake and can be used as an efficient delivery vector for therapeutic SSOs.
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Resolving power of diffraction imaging with an objective: a numerical study.Diffraction imaging in the far-field can detect 3D morphological features of an object for its coherent nature. We describe methods for accurate calculation and analysis of diffraction images of scatterers of single and double spheres by an imaging unit based on microscope objective at non-conjugate positions. A quantitative study of the calculated diffraction imaging in spectral domain has been performed to assess the resolving power of diffraction imaging. It has been shown numerically that with coherent illumination of 532 nm in wavelength the imaging unit can resolve single spheres of 2 μm or larger in diameters and double spheres separated by less than 300 nm between their centers.
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Antibody persistence following meningococcal C conjugate vaccination in children and adolescents infected with human immunodeficiency virus.HIV-infected individuals (HIVI) are threatened by meningococcal infection and presented lower response to vaccines. Data are scarce on long-term persistence of human serum bactericidal antibody (hSBA) after a meningococcal C conjugate (MCC) vaccine in HIVI youth; the authors aimed to describe this persistence in HIVI.
1487 related Products with: Antibody persistence following meningococcal C conjugate vaccination in children and adolescents infected with human immunodeficiency virus.Rabbit Anti-APIP Apaf1 In Rabbit Anti-TNIP2 ABIN2 T Rabbit Anti-intestinal FA Rabbit Anti-Cell death in Rabbit Anti-APIP Apaf1 In Anti-human C1 Esterase In Rabbit Anti-TNIP2 ABIN2 T Rabbit Anti-Cell death in Rabbit Anti-MDMX Polyclon Cytokine (Human) Antibody Rabbit Anti-Insulin Recep Rabbit Anti-AX2R LOC38928
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