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Release patterns of astrocytic and neuronal biochemical markers in serum during and after experimental settings of cardiac surgery.
Brain injury and altered psychomotor development in infants, children and adults after cardiac surgery using cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest (DHCA) is still a matter of concern. Early diagnosis and identification of brain injury that has occurred or is ongoing by measurement of biochemical markers in serum may have diagnostic and prognostic value. The aim of the experimental studies in an animal model was therefore to investigate the release patterns of astroglial and neuronal markers in serum and to determine the morphological and immunohistochemical changes in the brain of animals undergoing similar perfusion conditions of CPB and a period of DHCA.Hashim Abdul-Khaliq, Stephan Schubert, Gisela Stoltenburg-Didinger, Michael Huebler, Dirk Troitzsch, Anke Wehsack, Wolfgang Boettcher, Beat Schwaller, Michel Crausaz, Marco Celio, Matthias L Schröter, Ingolf E Blasig, Roland Hetzer, Peter E Lange
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96T500 tests500 tests 5 G2.5 mg50 ug 10 mg1 mg500 mlRelated Pathways
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