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#29055850   2017/10/22 Save this To Up

In vitro uptake and metabolism of [(14)C]acetate in rabbit atherosclerotic arteries: biological basis for atherosclerosis imaging with [(11)C]acetate.

Detection of vulnerable plaques is critically important for the selection of appropriate treatment and/or the prevention of atherosclerosis and ensuing cardiovascular diseases. In order to clarify the utility of [(11)C]acetate for atherosclerosis imaging, we determined the uptake and metabolism of acetate by in vitro studies using rabbit atherosclerotic arteries and [(14)C]acetate.

2249 related Products with: In vitro uptake and metabolism of [(14)C]acetate in rabbit atherosclerotic arteries: biological basis for atherosclerosis imaging with [(11)C]acetate.

Rabbit Anti-Inf A Neurami 1-Acetyl-3-indoxyl-d4 Ace 3-Amino-1,4-dimethyl-5H-p 3-Amino-1,4-dimethyl-5H-p 3-Amino-1-methyl-5H-pyrid 3-Amino-1-methyl-5H-pyrid 3-Indoxyl acetate CAS: [6 Interleukin-34 IL34 (N-t Interleukin-34 IL34 anti Human Interleukin-11 IL-1 Integrin â3 (Phospho Tyr Integrin â3 (Phospho Tyr

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#29055787   2017/10/22 Save this To Up

Occurrence of a stonefish toxin-like toxin in the venom of the rabbitfish Siganus fuscescens.

Rabbitfish belonging to the order Perciformes are well-known venomous fish that are frequently involved in human accidents. However little research has been done into either the whole venom toxicities or the structures and properties of their venom toxins. In this study, we first examined biological activities of the crude venom extract prepared from dorsal spines of Siganus fuscescens, a rabbitfish most commonly found along the coasts of Japan. As a result, the crude venom extract was shown to have mouse-lethal activity, hemolytic activity against rabbit erythrocytes, edema-forming activity and nociceptive activity, similar to the known scorpaeniform fish toxins (stonefish toxins and their analogues). Then, the primary structure of the S. fuscescens toxin was successfully elucidated by the same cDNA cloning strategy as previously employed for the toxins of some scorpaeniform fish (lionfish, devil stinger and waspfish). The S. fuscescens toxin is obviously an analogue of stonefish toxins, being composed of two kinds of subunits, an α-subunit of 703 amino acid residues and a β-subunit of 699 amino acid residues. Furthermore, the genes encoding both subunits were cloned from genomic DNA and shown to have an architecture of three exons and two introns, as reported for those of the scorpaeniform fish toxins. This study is the first to demonstrate the occurrence of stonefish toxin-like toxins in perciform fish.

2689 related Products with: Occurrence of a stonefish toxin-like toxin in the venom of the rabbitfish Siganus fuscescens.

Thermal Shaker with cooli FDA Standard Frozen Tissu FDA Standard Frozen Tissu FDA Standard Frozen Tissu FDA Standard Frozen Tissu FDA Standard Frozen Tissu FDA Standard Frozen Tissu Multiple organ tumor tiss Toxoplasma gondii GRA8, r FIV Core Ag, recombinant Shiga Toxin 1 antibody, M Shiga Toxin 2 antibody, M

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#29055734   2017/10/22 Save this To Up

Development of copolymeric nanoparticles of hypocrellin B: Enhanced phototoxic effect and ocular distribution.

In the present work, we have developed a photosensitizer hypocrellin B (HB) and nano silver loaded PLGA-TPGS nanoparticles with improved singlet oxygen production for enhanced photodynamic effect for the efficient treatment of age related macular degeneration. Random copolymer (PLGA-TPGS) synthesized by ring opening and bulk polymerization was characterized by IR, (1)H NMR and TGA analysis. HBS-CP-NPs prepared by nanoprecipitation techniques were spherical shaped 89.6-753.6nm size particles with negative zeta potential. The average encapsulation efficiency was 84.06±11.43% and HB release from the HBS-CP-NPs was found to be biphasic with a slow release of 1.41% in the first 8h and 48.91% during 3days as measured by RP-HPLC. DSC thermograms indicate that HB was dispersed as amorphous form in HBS-CP-NPs. The ROS generation level of HBS-CP-NPs was significantly higher than that of HB/HB-CP-NPs. The production of (1)O2 of HBS-NPs has been assessed using EPR spectrometer. The (1)O2 generating efficiency follows the order of nano silver>HB-CP-NPs>HBS-CP-NPs>pure HB drug solution. The superior phototoxic effect of HBS-CP-NPs (85.5% at 50μM) was attained at 2h irradiation in A549 cells. Significant anti angiogenic effect of HBS-CP-NPs was observed in treated CAM embryos. Following intravenous injection of HBS-CP-NPs to rabbits, the maximum amount of HB was found in retina (3h), iris (9h), aqueous humour (9h) and vitreous humour (9h).

2687 related Products with: Development of copolymeric nanoparticles of hypocrellin B: Enhanced phototoxic effect and ocular distribution.

Ofloxacin CAS Number [824 Nuclear Fast Red Solutio Nuclear Fast Red Solutio Nuclear Fast Red Solutio DNA (cytosine 5) methyltr Androgen Receptor (Phosph Androgen Receptor (Phosph Rabbit Anti-Human Androge Rabbit Anti-Human Androge Androgen Receptor (Ab 650 SMCC Plus™ *Enhanced wa Enhanced Green Fluorescen

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#29054974   2017/10/21 Save this To Up

Laryngeal closure impedes non-invasive ventilation at birth.

Non-invasive ventilation is sometimes unable to provide the respiratory needs of very premature infants in the delivery room. While airway obstruction is thought to be the main problem, the site of obstruction is unknown. We investigated whether closure of the larynx and epiglottis is a major site of airway obstruction.

1272 related Products with: Laryngeal closure impedes non-invasive ventilation at birth.

ATF3 Human Beta-cell Attractin Caspase-12 Inhibitor Z-AT Caspase-12 Inhibitor Z-AT Caspase 12 Inhibitor Z AT Caspase-12 Inhibitor Z-AT Caspase-12 Inhibitor Z-AT Caspase 12 Inhibitor Z AT ATF2 (Phospho Ser62 or 44 ATF2 (Phospho Thr69 or 51 ATF2 (Phospho Thr71 or 53 ATF2 (Phospho Thr73 or 55

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#29053245   2017/10/20 Save this To Up

Generation and Characterization of Recombinant Antibody-Like ADP-Ribose Binding Proteins.

ADP-ribosylation is an enzyme-catalyzed post-translational modification of proteins in which the ADP-ribose (ADPR) moiety of NAD+ is transferred to a specific amino acid in a substrate protein. The biological functions of ADP-ribosylation are numerous and diverse, ranging from normal physiology to pathological conditions. Biochemical and cellular studies of the diverse forms and functions of ADPR require immunological reagents that can be used for detection and enrichment. The lack of a complete set of tools that recognize all forms of ADPR [i.e., mono-, oligo-, and poly(ADP-ribose)] has hampered progress. Herein, we describe the generation and characterization of a set of recombinant antibody-like ADP-ribose binding proteins, in which naturally-occurring ADPR binding domains, including macrodomains and WWE domains, have been functionalized by fusion to the Fc region of rabbit immunoglobulin. These reagents, which collectively recognize all forms of ADPR with different specificities, are useful in a broad array of antibody-based assays, such as immunoblotting, immunofluorescent staining of cells, and immunoprecipitation. Observations from these assays suggest that the biology of ADPR is more diverse, rich, and complex than previously thought. The ARBD-Fc fusion proteins described herein will be useful tools for future exploration of the chemistry, biochemistry, and biology of ADP-ribose.

2613 related Products with: Generation and Characterization of Recombinant Antibody-Like ADP-Ribose Binding Proteins.

Anti Galectin(Gal 3) Huma Recombinant Human Androge Androgen Receptor (Phosph Androgen Receptor (Phosph ADP ribose pNP Recombinant Anti-Human CD Recombinant Anti-Human CD Recombinant Anti-Human CD Recombinant Anti-HBV HBsA Recombinant Anti-HBV HBsA Recombinant Anti-HBV HBsA Androgen Receptor (Ab 650

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#29052820   2017/10/20 Save this To Up

Evaluation of different treatment protocols for combined injury-induced lung injury in rabbits.

This study aims to evaluate the effectiveness of different treatment regimens on combined injury-induced lung injury.

1163 related Products with: Evaluation of different treatment protocols for combined injury-induced lung injury in rabbits.

Human Kidney injury molec Multiple lung carcinoma ( Anti AGO2 Human, Monoclon Anti AGO2 Mouse, Monoclon Anti AGO2 Human, Monoclon Anti AGO2 Mouse, Monoclon Growth Differentiation Fa Human Epstein-Barr Virus Jurkat Cell Extract (Indu Jurkat Cell Extract (Indu Jurkat Cell Extract (Indu Jurkat Cell Extract (Indu

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#29052327   2017/10/20 Save this To Up

CRISPR is knocking on barn door.

Genome modification at specific loci in livestock species was only achievable by performing homologous recombination in somatic cells followed by somatic cell nuclear transfer. The difficulty and inefficiency of this method have slowed down the multiple applications of genome modification in farm animals. The discovery of site-specific endonucleases has provided a different and more direct route for targeted mutagenesis, as these enzymes allow the ablation (KO) or insertion (KI) of specific genomic sequences on a single step, directly applied to zygotes. Clustered regularly interspaced short palindromic repeats (CRISPR), the last site-specific endonuclease to be developed, is a RNA-guided endonuclease, easy to engineer and direct to a given target site. This technology has been successfully applied to rabbits, swine, goats, sheep and cattle, situating genome editing in livestock species at an attainable distance, thereby empowering scientist to develop a myriad of applications. Genetically modified livestock animals can be used as biomodels to study human or livestock physiology and disease, as bioreactors to produce complex proteins, or as organ donors for transplantation. Specifically on livestock production, genome editing in farm animals may serve to improve productive genetic traits, to improve various animal products, to confer resistance to diseases or to minimize the environmental impact on farming. In this review, we provide an overview of the current methods for site-specific genome modification in livestock species, discuss potential and already developed applications of genome edition in farm animals and debate about the possibilities for approval of products derived from gene-edited animals for human consumption.

2592 related Products with: CRISPR is knocking on barn door.

B-Phycoerythrin antibody 2-Amino Benzimidazole Su 2-Amino Benzimidazole Su EZH2 KMT6 antibody Isoty Interleukin-34 IL34 (N-t Interleukin-34 IL34 anti CRC3 CD3 (bispecific) Cl 2,3 dinor 6 keto Prostag ROR1 Clone '1B4 antibody RBPMS HERMES Clone '1C12 Bcl-2 Oncoprotein; Clone Bcl-2 Oncoprotein; Clone

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#29052323   2017/10/20 Save this To Up

Chitosan-dextran sulphate nanoparticles for GnRH release in rabbit insemination extenders.

This study was designed to develop chitosan (CS)-dextran sulphate (DS) nanoparticles containing a GnRH analogue and to study their effect on rabbit (Oryctolagus cuniculus) semen quality. Six experimental extenders were tested as follows: (control) Tris-citric acid-glucose (TCG), (1) 0.05% CS-0.05% DS (4:1), (2) 0.1% CS-0.05% DS (4:1), (3) 0.05% CS-0.05% DS (3:1), (4) 0.1% CS-0.05% DS (3:1), (5) 0.1% CS-0.05% DS (2:1). CS and DS were dissolved in TCG medium, and nanoparticles were obtained through magnetic stirring. Rabbit seminal samples were incubated up to 5 hr at 37°C in the extenders, and seminal quality was evaluated. The entrapment efficiency was 40%-50%. After 5 hr at 37°C, a 20% of the hormone was released. Results showed that the presence of CS-DS nanoparticles did not affect rabbit semen motility, viability and membrane functionality; however, acrosome integrity was significantly higher versus control (p < .001).

2485 related Products with: Chitosan-dextran sulphate nanoparticles for GnRH release in rabbit insemination extenders.

Interleukin-34 IL34 (N-t Interleukin-34 IL34 anti Integrin â3 (Phospho Tyr Integrin â3 (Phospho Tyr Interferon-a Receptor Typ Rabbit Anti-Inf A Neurami Rabbit Anti-Influenza A H Rabbit Anti-Influenza A N Rabbit Anti-Influenza-A H Rabbit Anti-Influenza-A H Rabbit Anti-Influenza-A H Rabbit Anti-Influenza-A H

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#29051759   2017/10/20 Save this To Up

IFNγ Enhances CD64-Potentiated Phagocytosis of Treponema pallidum Opsonized with Human Syphilitic Serum by Human Macrophages.

Syphilis is a multi-stage, sexually transmitted disease caused by the spirochete Treponema pallidum (Tp). Considered broadly, syphilis can be conceptualized as a dualistic process in which spirochete-driven inflammation, the cause of clinical manifestations, coexists to varying extents with bacterial persistence. Inflammation is elicited in the tissues, along with the persistence of spirochetes to keep driving a robust immune response while evading host defenses; this duality is best exemplified during the florid, disseminated stage called secondary syphilis (SS). SS lesions typically contain copious amounts of spirochetes along with a mixed cellular infiltrate consisting of CD4(+) T cells, CD8(+) T cells, NK cells, plasma cells, and macrophages. In the rabbit model, Tp are cleared by macrophages via antibody-mediated opsonophagocytosis. Previously, we demonstrated that human syphilitic serum (HSS) promotes efficient uptake of Tp by human monocytes and that opsonophagocytosis of Tp markedly enhances cytokine production. Herein, we used monocyte-derived macrophages to study Tp-macrophage interactions ex vivo. In the absence of HSS, monocyte-derived macrophages internalized low numbers of Tp and secreted little cytokine (e.g., TNF). By contrast, these same macrophages internalized large numbers of unopsonized Borrelia burgdorferi and secreted robust levels of cytokines. Maturation of macrophages with M-CSF and IFNγ resulted in a macrophage phenotype with increased expression of HLA-DR, CD14, inducible nitric oxide synthase, TLR2, TLR8, and the Fcγ receptors (FcγR) CD64 and CD16, even in the absence of LPS. Importantly, IFNγ-polarized macrophages resulted in a statistically significant increase in opsonophagocytosis of Tp accompanied by enhanced production of cytokines, macrophage activation markers (CD40, CD80), TLRs (TLR2, TLR7, TLR8), chemokines (CCL19, CXCL10, CXCL11), and TH1-promoting cytokines (IL-12, IL-15). Finally, the blockade of FcγRs, primarily CD64, significantly diminished spirochetal uptake and proinflammatory cytokine secretion by IFNγ-stimulated macrophages. Our ex vivo studies demonstrate the importance of CD64-potentiated uptake of opsonized Tp and suggest that IFNγ-activated macrophages have an important role in the context of early syphilis. Our study results also provide an ex vivo surrogate system for use in future syphilis vaccine studies.

2723 related Products with: IFNγ Enhances CD64-Potentiated Phagocytosis of Treponema pallidum Opsonized with Human Syphilitic Serum by Human Macrophages.

Human Serum Albumin antib Human Serum Albumin antib Recombinant Human Serum A Recombinant Human Serum A Recombinant Human Serum A Native Human Serum Albumi Native Human Serum Albumi Native Human Serum Albumi Recombinant Human Serum A Recombinant Human Serum A Recombinant Human Serum A Recombinant Human Serum A

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#29051566   2017/10/20 Save this To Up

Characterization of old RHDV strains by complete genome sequencing identifies a novel genetic group.

Rabbit hemorrhagic disease (RHD) is a veterinary disease that affects the European rabbit and has a significant economic and ecological negative impact. In Portugal, rabbit hemorrhagic disease virus (RHDV) was reported in 1989 and still causes enzootic outbreaks. Several recombination events have been detected in RHDV strains, including in the first reported outbreak. Here we describe the occurrence of recombination in RHDV strains recovered from rabbit and Iberian hare samples collected in the mid-1990s in Portugal. Characterization of full genomic sequences revealed the existence of a single recombination breakpoint at the boundary of the non-structural and the structural encoding regions, further supporting the importance of this region as a recombination hotspot in lagoviruses. Phylogenetic analysis showed that in the structural region, the recombinant strains were similar to pathogenic G1 strains, but in the non-structural region they formed a new group that diverged ~13% from known strains. No further reports of such group exist, but this recombination event was also detected in an Iberian hare that was associated with the earliest species jump in RHDV. Our results highlight the importance of the characterization of full genomes to disclose RHDV evolution and show that lagoviruses' diversity has been significantly undersampled.

1866 related Products with: Characterization of old RHDV strains by complete genome sequencing identifies a novel genetic group.

Blood Group Antibodies a anti B human blood group MOUSE ANTI HUMAN CD173 - G protein-coupled recepto Blood Group Lewis a antib BYL-719 Mechanisms: PI3K- Mouse Anti-Legionella Ser Mouse Anti-Legionella pne Mouse Anti-Legionella Ser Mouse Anti-Legionella pne Mouse Anti-S. enteritidis Mouse Anti-Rotovirus Grou

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