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Search results for: Rat monoclonal anti mouse Interleukin 10 Anti-Mouse antibodies

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#24440156   2014/01/15 To Up

Anti-interleukin-6 receptor antibody (MR16-1) promotes muscle regeneration via modulation of gene expressions in infiltrated macrophages.

Although rat anti-mouse IL-6 receptor (IL-6R) antibody (MR16-1) has been reported to effectively ameliorate various tissue damages, its effect on skeletal muscle regeneration has not been determined. Moreover, the localization, persistence and duration of action of this reagent in damaged tissues after systemic administration have not been assessed.
Ryo Fujita, Fumimori Kawano, Takashi Ohira, Naoya Nakai, Tsubasa Shibaguchi, Norihiro Nishimoto, Yoshinobu Ohira

2265 related Products with: Anti-interleukin-6 receptor antibody (MR16-1) promotes muscle regeneration via modulation of gene expressions in infiltrated macrophages.

100ug100ug Lyophilized100ug100ug Lyophilized100ug Lyophilized100ug100ug 100ul100ug100ug100ug Lyophilized100ug

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#19301205   // To Up

Effects of interleukin-6 blockade on the development of autoimmune thyroiditis in nonobese diabetic mice.

We explored the role of interleukin-6 (IL-6) in the development of autoimmune thyroiditis in nonobese diabetic (NOD) mice, an animal model of Hashimoto's thyroiditis, using anti-mouse IL-6 receptor antibody (MR16-1). Thyroiditis was induced by iodide ingestion or mouse thyroglobulin (Tg) immunization. Mice were injected intraperitoneally with saline, control rat IgG, or MR16-1 (2 or 8 mg). Iodide ingestion did not increase serum IL-6 levels and MR16-1 (2 mg) failed to prevent the development of thyroiditis. In contrast, Tg immunization induced a rapid and significant increase in serum IL-6 levels. While MR16-1 (2 mg) had no effect on Tg-induced thyroiditis, the severity, but not incidence, of thyroiditis was reduced in 8 mg MR16-1-treated mice compared with saline-injected mice. However, thyroiditis development in the 8 mg MR16-1-treated mice was indistinguishable from that in the control IgG-treated mice. MR16-1 (8 mg) did not affect serum anti-Tg antibody levels. These results suggest that IL-6 may play only a minor role in the development of autoimmune thyroiditis in NOD mice.
Kouki Mori, Katsumi Yoshida, Masahiko Mihara, Yoshiyuki Ohsugi, Yoshinori Nakagawa, Saeko Hoshikawa, Hiroshi Ozaki, Sadayoshi Ito

1349 related Products with: Effects of interleukin-6 blockade on the development of autoimmune thyroiditis in nonobese diabetic mice.

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#7634801   // To Up

Contribution of tumor necrosis factor-alpha to pulmonary cytokine expression and lung injury after hemorrhage and resuscitation.

To examine the role of tumor necrosis factor-alpha (TNF-alpha) in producing acute inflammatory lung injury after hemorrhage and resuscitation.
E Abraham, G Jesmok, R Tuder, J Allbee, Y H Chang

1375 related Products with: Contribution of tumor necrosis factor-alpha to pulmonary cytokine expression and lung injury after hemorrhage and resuscitation.

96T0.1 mg5ug20 10ug 96T/Kit 5ug1 kit(96 Wells)1 kit(96 Wells)0.1 mg 5 G5ug

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