%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
2013-07-07T10:44:07+03:00
2013-07-07T10:44:06+03:00
2013-07-07T10:44:07+03:00
Adobe Acrobat 10.0
application/pdf
bs-9907R-Cy7.htm
uuid:fde14b47-4e21-453e-a57f-8dc44128f4c4
uuid:6f2ef5d7-101f-429a-8f5a-de0c1e2d1658
Acrobat Web Capture 10.0
endstream
endobj
5 0 obj
<>
endobj
6 0 obj
<>
endobj
3 0 obj
<>
endobj
7 0 obj
<>
endobj
8 0 obj
<>
endobj
15 0 obj
<>>>
endobj
16 0 obj
<>
endobj
17 0 obj
<>
endobj
19 0 obj
[18 0 R 18 0 R 18 0 R]
endobj
20 0 obj
[18 0 R 18 0 R 18 0 R]
endobj
18 0 obj
<><><>]/P 16 0 R/Pg 13 0 R/S/Article>>
endobj
13 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC/ImageI]/XObject<>>>/StructParents 0/Type/Page>>
endobj
21 0 obj
[35 0 R]
endobj
22 0 obj
<>stream
BT
/Artifact <>BDC
/TT0 1 Tf
8.1715 0 0 8.1715 5 779 Tm
(bs-9907R-Cy7)Tj
EMC
/Artifact <>BDC
0 -94.72 TD
(file:///F|/mimi/bs-9907R-Cy7.htm)Tj
([07/07/13 10:44:06])Tj
EMC
ET
1 g
10 765.984 591.75 -729.984 re
f
/Article <>BDC
BT
0.2 g
/TT1 1 Tf
6.8096 0 0 6.8096 21.5762 716.2742 Tm
(www.biossusa.com)Tj
0 -1.5 TD
(support@biossusa.com)Tj
-0.012 Tw T*
[(800.501.7654)-34( )1([DOMESTIC])]TJ
T*
[(+1.781.569.5821)-57( )1([INTERNATIONAL])]TJ
ET
q
456.707 678.821 145.043 81.715 re
W n
q
/GS0 gs
145.0434418 0 0 -81.7146149 456.7065582 760.5362396 cm
/Im0 Do
Q
Q
BT
0 g
/TT2 1 Tf
0 Tw 9.5334 0 0 9.5334 21.5762 663.1597 Tm
[(bs)-67(-)-69(9907R)-12(-)-69(Cy7)]TJ
/TT1 1 Tf
-0.04 Tw 7.4905 0 0 7.4905 29.0667 615.4928 Tm
[(Conjugated)-58( Primary)-1( Antibodies)]TJ
/TT2 1 Tf
0 Tw 0 -2.091 TD
(Background:)Tj
/TT1 1 Tf
-0.04 Tw 0 -1.455 TD
[(CPN2)-89( is)-52( a)-20( zinc)-35( metalloprotease,)-22( and cleaves)-62( carboxy)-20(-)-1(terminal)-35( arginines)-16( and lysines)-68( from)-30( peptides)-7( found)-15( in)-31( the)]TJ
0 -1.455 TD
[(bloodstream)-2( such)-68( as)-29( complement)-45( anaphylatoxins,)-30( kinins,)-88( and creatine)-26( kinase)-36( MM)-3( \(CK)-64(-)-1(MM\).)-45( By)-4( removing)-75( only)]TJ
0 -1.455 TD
[(one)-9( amino)-32( acid,)-20( CPN)-90( has)-16( the)-36( ability)-39( to)-32( change)-1( peptide)-90( activity)-74( and receptor)-64( binding.)-9( It)-20( is)-52( a)-20( 280)-89( kDa)-26( tetrameric)]TJ
0 -1.455 TD
[(glycoprotein)-67( that)-67( is)-52( synthesized)-64( by)-40( the)-37( liver)-67( and secreted)-86( into)-63( the)-36( plasma.)-34( It)-20( consists)-82( of)-48( 2)-90( identical)-83( 83)-90( kDa)]TJ
0 -1.455 TD
[(regulatory)-59( subunits)-45( \(CPN2\))-51( and 2)-90( identical)-83( 50)-90( kDa)-26( catalytic)-40( subunits)-45( \(CPN1\).)-20( CPN2,)-59( the)-37( 83)-90( kDa)-26( subunit,)-6( binds)]TJ
T*
[(and stabilizes)-39( the)-37( catalytic)-40( subunit)-37( at)-50( 37)-90( degrees)-55( Celsius)-56( and keeps)-87( it)-73( in)-31( circulation.)-28( Under)-74( some)-9( circumstances)-68( it)]TJ
0 -1.455 TD
[(may)-46( be)-12( an)-8( allosteric)-27( modifier)-38( of)-48( the)-36( catalytic)-40( subunit.)-6( CPN)-90( is)-52( a)-20( member)-82( of)-48( a)-20( larger)-83( family)-88( of)-48( carboxypeptidases,)]TJ
T*
[(many)-33( of)-48( which)-88( also)-75( cleave)-53( arginine)-7( and lysine.)-29( Because)-5( of)-48( the)-37( highly)-11( conserved)-74( active)-63( sites)-19( and the)-37( possible)]TJ
0 -1.455 TD
[(redundant)-20( functions)-86( of)-48( carboxypeptidases,)-25( it)-73( has)-16( been)-19( difficult)-44( to)-32( elucidate)-59( the)-37( role)-69( of)-48( CPN)-90( in)-31( disease)-22( processes.)]TJ
/TT2 1 Tf
0 Tw 0 -1.909 TD
(Purification:)Tj
/TT1 1 Tf
-0.04 Tw 6.727 -0.091 Td
[(Was)-36( purified)-38( by)-40( Protein)-81( A)-36( and peptide)-90( affinity)-82( chromatography.)]TJ
/TT2 1 Tf
0 Tw -6.727 -2 Td
(Storage:)Tj
/TT1 1 Tf
-0.04 Tw 0 -1.455 TD
[(Prepared)-46( as)-29( lyophilized)-45( powder)-87( or)-6( liquid)-13( and shipped)-37( on)-81( ice.)-26( Store)-44( at)-50( -)-1(20\260C)-18( for)-52( one)-9( year.)-61( Protect)-73( from)-30( light.)]TJ
/TT2 1 Tf
0 Tw 0 -1.909 TD
(Reconstitution:)Tj
/TT1 1 Tf
-0.04 Tw 0 -1.455 TD
[(If)-36( the)-36( antibody)-25( is)-52( in)-31( liquid)-13( form,)-91( it)-73( is)-52( ready)-83( to)-32( use,)-76( no)-81( reconstitution)-78( needed.)]TJ
0 -2.909 TD
[(Reconstitution)-90( is)-52( only)-81( required)-62( for)-52( the)-37( lyophilized)-45( antibody.)-86( Please)-15( refer)-92( to)-32( the)-37( reconstitution)-78( instruction)-26( card)-10( in)]TJ
0 -1.455 TD
[(the)-36( package.)]TJ
/TT2 1 Tf
0 Tw 54.182 31.273 Td
(Size:)Tj
/TT1 1 Tf
-0.04 Tw 3 -0.091 Td
[(100ul)-29( or)-6( 100ug)-69( lyophilized)]TJ
/TT2 1 Tf
0 Tw -3 -2.818 Td
(Concentration:)Tj
/TT1 1 Tf
8.091 -0.091 Td
(1ug/uL)Tj
/TT2 1 Tf
-8.091 -2.818 Td
(Host:)Tj
/TT1 1 Tf
3.273 -0.091 Td
(Rabbit)Tj
/TT2 1 Tf
-3.273 -1.909 Td
(Reactivities:)Tj
0.2 g
/TT1 1 Tf
6.8096 0 0 6.8096 434.916 568.5069 Tm
(Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,)Tj
0 g
/TT2 1 Tf
7.4905 0 0 7.4905 434.916 554.2068 Tm
(Application:)Tj
ET
q
10 36 592 730 re
W n
q 1 0 0 1 445.1303 536.1616 cm
0 0 m
0 1.362 -2.043 1.362 -2.043 0 c
-2.043 -1.362 0 -1.362 0 0 c
f
Q
Q
BT
/TT1 1 Tf
7.4905 0 0 7.4905 451.9399 534.4592 Tm
[(IF\(1:50)-4(-)-1(200\))]TJ
ET
q
10 36 592 730 re
W n
q 1 0 0 1 445.1303 525.2662 cm
0 0 m
0 1.362 -2.043 1.362 -2.043 0 c
-2.043 -1.362 0 -1.362 0 0 c
f
Q
Q
BT
/TT1 1 Tf
-0.04 Tw 7.4905 0 0 7.4905 451.9399 523.5638 Tm
[(Not)-1( yet)-6( tested)-8( in)-31( other)-43( applications.)]TJ
T*
[(Optimal)-36( working)-62( dilutions)-48( must)-4( be)]TJ
0 -1.455 TD
[(determined)-86( by)-40( the)-36( end)-90( user.)]TJ
/TT2 1 Tf
-0.02 Tw -2.273 -3.818 Td
[(Antibody)-48( Type:)]TJ
/TT1 1 Tf
0 Tw 8.182 -0.091 Td
(Polyclonal)Tj
/TT2 1 Tf
-8.182 -1.909 Td
(Isotype:)Tj
0.2 g
/TT1 1 Tf
6.8096 0 0 6.8096 479.1781 458.1922 Tm
(IgG)Tj
0 g
/TT2 1 Tf
-0.02 Tw 7.4905 0 0 7.4905 434.916 443.8921 Tm
[(Molecular)-1( Weight:)]TJ
0.2 g
/TT1 1 Tf
0 Tw 6.8096 0 0 6.8096 515.9496 443.8921 Tm
(58kDa)Tj
0 g
/TT2 1 Tf
7.4905 0 0 7.4905 434.916 429.5921 Tm
(Preservatives:)Tj
0.2 g
/TT1 1 Tf
-0.012 Tw 6.8096 0 0 6.8096 500.9686 429.5921 Tm
[(10ug/uL)-59( )1(BSA)-54( )1(and)-64( )1(0.1%)-28( )1(NaN3.)]TJ
0 g
0.021 Tw 6.1286 0 0 6.1286 434.916 401.6729 Tm
[(For)-20( )1(research)-16( )1(use)-25( )1(only.)-91( )1(CAUTION:)-13( )1(Not)-12( )1(for)-1( )1(human)-72( )1(or)]TJ
0 -1.333 TD
[(animal)-94( )1(therapeutic)-36( )1(or)-97( )1(diagnostic)-13( )1(use.)]TJ
ET
q
18.852 653.626 578.812 0.681 re
W n
q
/GS0 gs
578.8118286 0 0 -0.680954 18.852417 654.307251 cm
/Im1 Do
Q
Q
q
10 36 592 730 re
W n
0.302 0.306 0.333 rg
q 1 0 0 1 19.5334 638.6453 cm
0 0 m
0 1.816 -2.724 1.816 -2.724 0 c
-2.724 -1.816 0 -1.816 0 0 c
f
Q
Q
BT
0.302 0.306 0.333 rg
/TT2 1 Tf
-0.007 Tw 9.5334 0 0 9.5334 29.0667 635.9214 Tm
[(Rabbit)-50( Anti)-28(-)-69(CPN2)-54( Polyclonal)-4( Antibody,)-47( Cy7)-48( conjugated)]TJ
0 g
/TT1 1 Tf
0 Tw /Span<>> BDC
10.8953 0 0 10.8953 25.662 313.8297 Tm
( )Tj
EMC
/Span<>> BDC
12.063 0 Td
( )Tj
EMC
/Span<>> BDC
12.125 0 Td
( )Tj
EMC
/Span<>> BDC
-24.188 -2.25 Td
( )Tj
EMC
/Span<>> BDC
12.063 0 Td
( )Tj
EMC
/Span<>> BDC
12.125 0 Td
( )Tj
EMC
/Span<>> BDC
-24.188 -2.25 Td
( )Tj
EMC
/Span<>> BDC
12.063 0 Td
( )Tj
EMC
/Span<>> BDC
12.125 0 Td
( )Tj
EMC
-0.04 Tw 7.4905 0 0 7.4905 27.0239 232.1151 Tm
[(For)-30( full)-30( size)-82( images)-63( and description)-26( please)-13( click)-31( )]TJ
0 0.6 0.8 rg
0 Tw 6.8096 0 0 6.8096 185.0055 232.1151 Tm
(HERE)Tj
0 g
7.4905 0 0 7.4905 202.0293 232.1151 Tm
(.)Tj
ET
q
420.616 40.766 0.681 612.859 re
W n
q
/GS0 gs
0.680954 0 0 -612.8595886 420.6159363 653.6262665 cm
/Im2 Do
Q
EMC
/Article <>BDC
EMC
/Article <>BDC
EMC
Q
endstream
endobj
23 0 obj
<>
endobj
24 0 obj
(^uʩx LZyg\\u)
endobj
32 0 obj
<>stream
Hy\E323#3
P̴,HLEK"+E+2VTD%EH# }wfwfvvc_3?{feޝ@HHHHHH*豘V]
zן)@-9.q2BÇEڂ8g "2vn>u2]/Yz \S@ 7.M&p?o9v 0'rKś-;(Au.J%% %&˶0>6`TxOzzo(VDY*AZp ËgAs^.㮌+2Ȱ$E['FC:OMCIVVDD3}`u߈buߨɴ4қԭV^V0XF ϓ@i|Y|.?i'3}Ŵ+ޘaa:
3g},F"kNɳՕx57,H)X7*v/Mո+(fWr=WӃJcߓtG16sPt:t"9G
if
3do\ˢ|c:1&<ЭWnPdq0IRgu~惘n9BWV2T6~}rs4h-D.sgV/n3;q@hThI*jTJqJK2c!QT7;60
5NoJݻ'rBP%ȍ4
P(/CJC1
9eڴ}5S{"wty@P5e*Zg~?S(Sɗ,ʽv 2[̋t_Z\d&}/2YϹO&y#
?P>,0P-
asds[U꼩\=T~)S>B,gk$7+j0?60<&uźg
A]_@en%Mȝ~5PSu$^2s0RSPw L9٦n9$vڣ=f#g 7,Oa
:ܾ.4+H!=MvF(G|YU
ITR)>@✧*[j5KoB{Kp,`姙$JO궒jvż@r3`w\A%jSx+>m;5ا@._1:T#q]wrTC8r:lU4P}~Y]XwJ~b:YQϗLP-X_ֻа2$ݥC=~P]VҘLhu?S'\C:7"4dD*%9 Ogfe\OLoTy5Qkj.84,: t:_YON3˃:O/r犁3t!Psbty{aETu7nMѶ f+^Y6zHic?R%+C,γL =ZJ1H+,x^
I!u2{5x_@LI6[w5LN5:xXoEgf9tu=yùw=aґza*҃K`驪eP/y*sσn3N{ME\8g: *fz#W??L