Product name :Beta Amyloid (1 40) ELISA Kit II, Human Alzheimer''s Disease (AD) is characterized by the presence of extracellular senile plaques (SPs) and intracellular neurofibrillary tangles (NFT) in the brain. T
Catalog Number :298-64601
Quantity :96 tests
Price :1040.55 Eur
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Alzheimer''s Disease (AD) is characterized by the presence of extracellular senile plaques (SPs) and intracellular neurofibrillary tangles (NFT) in the brain. The major protein component of SPs is b Amyloid peptide (Ab) 40 and 42(43). Ab42 is more prone to aggregate than Ab. Therefore the initial Ab deposition begins with Ab42(43) but not with Ab40. Ab42(43)-positive and Ab40-negative plaques may represent early-stage diffuse type SPs, and Ab40-positive plaque appears in the advanced stage, especially more often in the cored portion of the mature plaque. In these kits, we use the monoclonal antibodies which specifically detect Ab. Therefore these kits are designed to be used for the quantitative determination of Ab in samples such as tissue culture medium, tissue homogenate, CSF and plasma.
Th ese products are detection kits that achieve more stable antigenantibody reactions by using F(ab')2 fragment of the labeled antibody BA27, which recognizes the C-terminal of Ab 40, while the nonspecifi c
binding is remaining to be reduced. Th erefore, the stability in washing solution is improved. In Human/Rat kit, background is reduced.