AHP1233 recognises glycogen synthase 3 (GSK3) beta phosphorylated at serine 9. This is a 46 kDa member of the serine/threonine protein kinase family. Two isforms of GSK3 exist, alpha and beta. GSK3 beta is expressed in the testis, thymus, prostate, and ovary as well as being expressed at low levels in lung, brain and kidney tissue.

GSK3 beta is involved in many signalling pathways including energy metabolism, body pattern formation and microtubule growth and stability (which aids axon growth). GSK3 beta is also thought to be involved in oncogenesis and the hormonal control of several regulatory proteins including glycogen synthase.

Phosphorylation of serine-9 inhibits GSK3 beta function.

Rat

Target Species	Cross Reactivity
Bovine	Expected from Sequence
Chicken	Expected from Sequence
Dog	Expected from Sequence
Human	Expected from Sequence
Mouse	Expected from Sequence
Primate	Expected from Sequence
Xenopus	Expected from Sequence
Zebrafish	Expected from Sequence

Purified IgG - liquid

0.09%	Sodium Azide (NaN3)
50%	Glycerol
0.01%	Bovine Serum Albumin

Phosphopeptide corresponding to amino acid sequence surrounding phoshorylated seine 9 of rat GSK3 beta.

10mM Hepes pH7.5